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公开(公告)号：US07341731B2
公开(公告)日：2008-03-11
申请号：US10180460
申请日：2002-06-27
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： A61K39/21
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The invention relates to a composition comprising at least one antigen, wherein the antigen is a protein or glycoprotein of a HIV-2 virus, wherein the HIV-2 virus has infectious properties with respect to human T4 lymphocytes and the essential morphological or immunological property of at least one of the retroviruses deposited at the CNCM under No. I-502, I-532, I-642, and I-643. It also relates to a process for the production of HIV-2 retrovirus antigens by lysing cells infected with the virus or lysing purified virus and recovering the antigens.
摘要翻译： 本发明涉及包含至少一种抗原的组合物，其中所述抗原是HIV-2病毒的蛋白质或糖蛋白，其中所述HIV-2病毒相对于人T4淋巴细胞具有感染性质，以及所述HIV-2病毒的基本形态学或免疫学性质 至少有一种在CNCM下存放在I-502，I-532，I-642和I-643下的逆转录病毒。 它还涉及通过裂解感染病毒的细胞或裂解纯化的病毒并回收抗原来生产HIV-2逆转录病毒抗原的方法。
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2.发明授权Cloned DNA sequence related to genomic RNA of human immunodeficiency virus (HIV-1) 失效与人类免疫缺陷病毒（HIV-1）的基因组RNA相关的克隆DNA序列公开(公告)号：US07217508B1
公开(公告)日：2007-05-15
申请号：US07158652
申请日：1988-02-22
申请人： Simon Wain-Hobson , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C07K14/005 , C12N2740/16021 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译： 本发明在淋巴结病毒病毒领域已被指定为1型HIV-1型人类免疫缺陷病毒。 本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。 本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。
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公开(公告)号：US06600023B1
公开(公告)日：2003-07-29
申请号：US08019297
申请日：1993-02-18
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C07K1600
CPC分类号： C07K16/1045 , C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , G01N2333/16
摘要： Antibodies which bind with antigens of human immunodeficiency virus type 1 (HIV-1), such as Lymphadenopathy Associated Virus (LAV), are disclosed. Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS) are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. Viral extracts, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients.
摘要翻译： 公开了与人类免疫缺陷病毒1型（HIV-1）的抗原结合的抗体，例如淋巴结病相关病毒（LAV）。 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒从患有淋巴结病综合征（LAS）或AIDS的患者的血清中分离。 逆转录病毒的病毒提取物，结构蛋白和其他部分免疫识别这些患者的血清。
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4.发明授权In vitro diagnostic methods and kits for the detection of HIV-2-specific antibodies 失效用于检测HIV-2特异性抗体的体外诊断方法和试剂盒公开(公告)号：US06265149B1
公开(公告)日：2001-07-24
申请号：US08470491
申请日：1995-06-06
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： C12Q170
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The claimed invention is directed toward in vitro methods for the detection of human immunodeficiency virus type 2 (HIV-2) antibodies employing polypeptide fragments of HIV-2 Gag.
摘要翻译： 所要求保护的发明涉及使用HIV-2Gag的多肽片段检测使用HIV-2抗体的人类免疫缺陷病毒的体外方法。
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5.发明授权DNA sequence of the LTR region of human immunodeficiency virus type 1 (HIV-1) 失效人类免疫缺陷病毒1型（HIV-1）的LTR区的DNA序列公开(公告)号：US07232654B1
公开(公告)日：2007-06-19
申请号：US08308219
申请日：1994-09-19
申请人： Jean-Claude Chermann , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1) to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates tot he DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译： 本发明属于淋巴结病毒病毒领域，已被指定为1型HIV（1型）免疫缺陷病毒（HIV-1），用于检测与获得性免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在 通过使用DNA片段或由所述DNA片段编码的肽。 本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。
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6.发明授权Retrovirus capable of causing AIDS, means and methods for detecting it in vitro 失效能够引起艾滋病的逆转录病毒，体外检测方法和方法公开(公告)号：US07115363B1
公开(公告)日：2006-10-03
申请号：US08470489
申请日：1995-06-06
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Francoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Francoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： C12Q1/70
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers 12.398 and 12.399.It relates also to antigens capable to be obtained from this virus, particularly proteins p12, p16, p26 and gp140. These various antigens can be used for the diagnosis of the disease, especially by contacting these antigens with a serum of a patient submitted to the diagnosis.It relates to immunogenic compositions containing more particularly the glycoprotein gp140. Finally it concerns nucleotidic sequences, which can be used especially as hybridization probes, derived from the RNA of HIV-2.
摘要翻译： 本发明涉及由HIV-2指定的一类新的逆转录病毒，其中样品已经按照号码87.01.1001和87.01.1002保藏在ECACC，编号为12.398和12.399的NCIB。 它还涉及能够从该病毒获得的抗原，特别是蛋白质p12，p16，p26和gp140。 这些各种抗原可以用于疾病的诊断，特别是通过将这些抗原与患者的血清接触进行诊断。 本发明涉及更具体地包含糖蛋白gp140的免疫原性组合物。 最后，它涉及核苷酸序列，其可以特别用作衍生自HIV-2的RNA的杂交探针。
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公开(公告)号：US06664041B2
公开(公告)日：2003-12-16
申请号：US09862511
申请日：2001-05-23
申请人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
发明人： Luc Montagnier , Solange Chamaret , Denise Guetard , Marc Alizon , François Clavel , Mireille Guyader , Pierre Sonigo , Françoise Brun-Vezinet , Marianne Rey , Christine Rouzioux , Christine Katlama
IPC分类号： C12Q170
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , C07K14/005 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , C12Q1/703 , G01N33/56988 , G01N2333/162 , G01N2469/20
摘要： The invention relates to a new class of retroviruses, designated by HIV-2, of which samples have been deposited to the ECACC under numbers 87.01.1001 and 87.01.1002 and to the NCIB under numbers 12.398 and 12.399. It relates also to antigens capable to be obtained from this virus, particularly proteins p12, p16, p26 and gp140. These various antigens can be used for the diagnosis of the disease, especially by contacting these antigens with a serum of a patient submitted to the diagnosis. It relates to immunogenic compositions containing more particularly the glycoprotein gp140. Finally it concerns nucleotidic sequences, which can be used especially as hybridization probes, derived from the RNA of HIV-2.
摘要翻译： 本发明涉及由HIV-2指定的一类新的逆转录病毒，其中样品已经以数字87.01.1001和87.01.1002保藏在ECACC中，并且编号为12.398和12.399的NCIB。还涉及抗原能力 从该病毒获得，特别是蛋白质p12，p16，p26和gp140。 这些各种抗原可以用于疾病的诊断，特别是通过使这些抗原与患者的血清接触进行诊断。其涉及包含更特别是糖蛋白gp140的免疫原性组合物。 最后，它涉及核苷酸序列，其可以特别用作衍生自HIV-2的RNA的杂交探针。
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8.发明授权Oligopeptides comprising p18 protein of human immunodeficiency virus (HIV), compositions comprising peptides of p18 protein of HIV, and diagnostic kits and methods for detecting acquired immune deficiency syndrome (AIDS) 失效包含人免疫缺陷病毒（HIV）的p18蛋白的寡肽，包含HIV的p18蛋白的肽的组合物和用于检测获得性免疫缺陷综合征（AIDS）的诊断试剂盒和方法，
公开(公告)号：US5374519A
公开(公告)日：1994-12-20
申请号：US952252
申请日：1992-09-28
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Brun , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Brun , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974
摘要： Protein compositions containing the p18 and p25 proteins of the lymphadenopathy virus are used for detecting antibodies in blood serum as indicative of infection by such virus. The proteins can be used in various conventional ways to perform immunoassays for the detection of the antibodies.
摘要翻译： 含有淋巴结病毒病毒的p18和p25蛋白质的蛋白质组合物用于检测血清中的抗体，作为这种病毒感染的指示。 蛋白质可以以各种常规方式用于进行用于检测抗体的免疫测定。
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9.发明授权Human Immunodeficiency Virus (HIV) associated with Acquired Immunual Deficiency Syndrome (AIDS), a diagnostic method for aids and pre-aids, and a kit therefor 失效与获得性免疫缺陷综合征（AIDS）相关的人类免疫缺陷病毒（HIV），辅助和预辅助的诊断方法及其工具包
公开(公告)号：US5135864A
公开(公告)日：1992-08-04
申请号：US117937
申请日：1987-11-05
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫识别这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。 提供了用于LAS或AIDS的体外测定的试剂盒。
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10.发明授权Methods and kits employing LAV antigens for the detection of HIV-1-specific antibodies 失效用于检测针对HIV变体的抗体的方法和试剂盒公开(公告)号：US06428952B1
公开(公告)日：2002-08-06
申请号：US08424631
申请日：1995-04-19
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
IPC分类号： C12Q170
CPC分类号： C07K16/1045 , G01N2333/16
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recongize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫学上述了这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。
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