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1.发明授权DNA sequence of the LTR region of human immunodeficiency virus type 1 (HIV-1) 失效人类免疫缺陷病毒1型（HIV-1）的LTR区的DNA序列公开(公告)号：US07232654B1
公开(公告)日：2007-06-19
申请号：US08308219
申请日：1994-09-19
申请人： Jean-Claude Chermann , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Simon Wain-Hobson , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1) to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates tot he DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译： 本发明属于淋巴结病毒病毒领域，已被指定为1型HIV（1型）免疫缺陷病毒（HIV-1），用于检测与获得性免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在 通过使用DNA片段或由所述DNA片段编码的肽。 本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。
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2.发明授权Oligopeptides comprising p18 protein of human immunodeficiency virus (HIV), compositions comprising peptides of p18 protein of HIV, and diagnostic kits and methods for detecting acquired immune deficiency syndrome (AIDS) 失效包含人免疫缺陷病毒（HIV）的p18蛋白的寡肽，包含HIV的p18蛋白的肽的组合物和用于检测获得性免疫缺陷综合征（AIDS）的诊断试剂盒和方法，
公开(公告)号：US5374519A
公开(公告)日：1994-12-20
申请号：US952252
申请日：1992-09-28
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Brun , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Brun , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974
摘要： Protein compositions containing the p18 and p25 proteins of the lymphadenopathy virus are used for detecting antibodies in blood serum as indicative of infection by such virus. The proteins can be used in various conventional ways to perform immunoassays for the detection of the antibodies.
摘要翻译： 含有淋巴结病毒病毒的p18和p25蛋白质的蛋白质组合物用于检测血清中的抗体，作为这种病毒感染的指示。 蛋白质可以以各种常规方式用于进行用于检测抗体的免疫测定。
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3.发明授权Human Immunodeficiency Virus (HIV) associated with Acquired Immunual Deficiency Syndrome (AIDS), a diagnostic method for aids and pre-aids, and a kit therefor 失效与获得性免疫缺陷综合征（AIDS）相关的人类免疫缺陷病毒（HIV），辅助和预辅助的诊断方法及其工具包
公开(公告)号：US5135864A
公开(公告)日：1992-08-04
申请号：US117937
申请日：1987-11-05
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫识别这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。 提供了用于LAS或AIDS的体外测定的试剂盒。
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4.发明授权Methods and kits employing LAV antigens for the detection of HIV-1-specific antibodies 失效用于检测针对HIV变体的抗体的方法和试剂盒公开(公告)号：US06428952B1
公开(公告)日：2002-08-06
申请号：US08424631
申请日：1995-04-19
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , G. Sarngadharan
IPC分类号： C12Q170
CPC分类号： C07K16/1045 , G01N2333/16
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recongize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫学上述了这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。
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公开(公告)号：US06395495B1
公开(公告)日：2002-05-28
申请号：US09437126
申请日：1999-11-10
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Robert C Gallo , Mikulas Popovic , Mangalasseril G Sarngadhar , Claudine Axler-Blin , Solange Chamaret
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Robert C Gallo , Mikulas Popovic , Mangalasseril G Sarngadhar , Claudine Axler-Blin , Solange Chamaret
IPC分类号： G01N3353
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222
摘要： The invention concerns a retrovirus extract containing a p25 protein which recognizes immunologically sera of patients afflicted with lymphadenopathy syndrom (LAS) or acquired immune deficiency syndrom (AIDS). It relates to a method and kit for in vivo assay of LAS or AIDS involving contacting sera from patients to be diagnosed for such diseases with said retrovirus extract and by detecting the immunological reaction, if any.
摘要翻译： 本发明涉及含有p25蛋白的逆转录病毒提取物，其识别患有淋巴结肿大综合征（LAS）或获得性免疫缺陷综合征（AIDS）的患者的免疫血清。 其涉及用于LAS或AIDS的体内测定的方法和试剂盒，其涉及将待诊断患者的血清与所述逆转录病毒提取物接触并通过检测免疫反应（如果有的话）接触。
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6.发明授权Human immunodeficiency viruses associated with Acquired Immune Deficiency Syndrome (AIDS), a diagnostic method for AIDS and pre-AIDS, and a kit therefor 失效与获得性免疫缺陷综合征（AIDS）相关的人体免疫机能丧失病毒，艾滋病和艾滋病前期的诊断方法及其试剂盒
公开(公告)号：US4708818A
公开(公告)日：1987-11-24
申请号：US785638
申请日：1985-10-08
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： A61K35/76 , A61K35/12 , A61K35/28 , A61K39/00 , A61K39/21 , A61P31/12 , A61P31/18 , C07K14/005 , C07K14/155 , C07K14/16 , C07K14/195 , C12N5/10 , C12N7/00 , C12N7/02 , C12N15/09 , C12Q1/70 , C12R1/92 , G01N33/569 , G01N33/535 , G01N33/543
CPC分类号： C07K14/005 , C12N7/00 , G01N33/56988 , C12N2740/16021 , C12N2740/16051 , C12N2740/16222 , Y10S435/81 , Y10S435/948 , Y10S435/974 , Y10S436/804 , Y10S436/808 , Y10S436/811
摘要： Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS), including Lymphadenopathy Associated Virus (LAV), are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. LAV is a Human Immunodeficiency Virus (HIV). Viral extract, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients. Immunological reaction is used to detect antibodies that specifically bind to antigenic sites of the retrovirus in samples of body fluids from patients with AIDS or risk of AIDS. A kit for in vitro assay of LAS or AIDS is provided.
摘要翻译： 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒，包括淋巴结病相关病毒（LAV），从患有淋巴结病综合征（LAS）或AIDS的患者血清中分离。 LAV是人类免疫缺陷病毒（HIV）。 病毒提取物，结构蛋白和其他部分的逆转录病毒免疫识别这些患者的血清。 免疫反应用于检测具有艾滋病或艾滋病风险的患者体液样品中特异性结合逆转录病毒抗原位点的抗体。 提供了用于LAS或AIDS的体外测定的试剂盒。
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7.发明授权Cloned DNA sequence related to genomic RNA of human immunodeficiency virus (HIV-1) 失效与人类免疫缺陷病毒（HIV-1）的基因组RNA相关的克隆DNA序列公开(公告)号：US07217508B1
公开(公告)日：2007-05-15
申请号：US07158652
申请日：1988-02-22
申请人： Simon Wain-Hobson , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Pierre Tiollais , Marc Alizon , Pierre Sonigo , Stewart Cole , Oliver Danos , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
CPC分类号： C07K14/005 , C12N2740/16021 , C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus, which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译： 本发明在淋巴结病毒病毒领域已被指定为1型HIV-1型人类免疫缺陷病毒。 本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。 本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。
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公开(公告)号：US06600023B1
公开(公告)日：2003-07-29
申请号：US08019297
申请日：1993-02-18
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Brun-Vezinet , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Therese Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C07K1600
CPC分类号： C07K16/1045 , C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , G01N2333/16
摘要： Antibodies which bind with antigens of human immunodeficiency virus type 1 (HIV-1), such as Lymphadenopathy Associated Virus (LAV), are disclosed. Retroviruses associated with Acquired Immune Deficiency Syndrome (AIDS) are isolated from the sera of patients afflicted with Lymphadenopathy Syndrome (LAS) or AIDS. Viral extracts, structural proteins and other fractions of the retrovirus immunologically recognize the sera of such patients.
摘要翻译： 公开了与人类免疫缺陷病毒1型（HIV-1）的抗原结合的抗体，例如淋巴结病相关病毒（LAV）。 与获得性免疫缺陷综合征（AIDS）相关的逆转录病毒从患有淋巴结病综合征（LAS）或AIDS的患者的血清中分离。 逆转录病毒的病毒提取物，结构蛋白和其他部分免疫识别这些患者的血清。
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9.发明授权Cloned DNA sequences related to the genomic RNA of lymphadenopathy-associated virus (LAV) and proteins encoded by said LAV genomic RNA 失效与淋巴结病毒相关病毒（LAV）的基因组RNA相关的克隆DNA序列和由所述LAV基因组RNA编码的蛋白质公开(公告)号：US07205102B1
公开(公告)日：2007-04-17
申请号：US08475822
申请日：1995-06-07
申请人： Luc Montagnier , Solange Chamaret , Claudine Axler-Blin , Francoise Rey , Marie-Therese Nugeyre , Jacques Gruest, legal representative , Charles Dauguet , Willy Rozenbaum , Christine Rouzioux , Francois Brun-Vezinet , Jean-Claude Chermann , Francoise Barre-Sinoussi , Robert C. Gallo , Mikulas Popovic , Mangalasseril G. Sarngadharan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/703
摘要： This invention is in the field of lymphadenopathy virus which has been designated Human Immunodeficiency Virus Type 1 (HIV-1). This invention relates to a diagnostic means and method to detect the presence of DNA, RNA or antibodies of the lymphadenopathy retrovirus associated with the acquired immune deficiency syndrome or of the lymphadenopathy syndrome by the use of DNA fragments or the peptides encoded by said DNA fragments. The invention further relates to the DNA fragments, vectors comprising them and the proteins expressed.
摘要翻译： 本发明属于已被指定为1型HIV（1型）免疫缺陷病毒的淋巴结病毒病毒。 本发明涉及通过使用DNA片段或由所述DNA片段编码的肽来检测与所获得的免疫缺陷综合征或淋巴结病综合征相关的淋巴结病变逆转录病毒的DNA，RNA或抗体的存在的诊断方法和方法。 本发明还涉及DNA片段，包含它们的载体和表达的蛋白质。
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10.发明授权Antibodies which bind with proteins of human immunodeficiency virus type 1 (HIV-1), and immune complexes comprising proteins of HIV-1 失效与人类免疫缺陷病毒1型（HIV-1）的蛋白质结合的抗体和包含HIV-1蛋白的免疫复合物公开(公告)号：US07122188B1
公开(公告)日：2006-10-17
申请号：US08067148
申请日：1993-05-26
申请人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Bruil , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
发明人： Luc Montagnier , Jean-Claude Chermann , Francoise Barre-Sinoussi , Francoise Vezinet-Bruil , Christine Rouzioux , Willy Rozenbaum , Charles Dauguet , Jacqueline Gruest , Marie-Theresa Nugeyre , Francoise Rey , Claudine Axler-Blin , Solange Chamaret
IPC分类号： A61K39/42
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/16051 , C12N2740/16222 , Y10S435/974 , Y10S930/221
摘要： This invention provides antibodies which bind with p12 and p18 proteins of a human immunodeficiency virus type 1 (HIV-1), antibodies which bind with immune complexes comprising p12 or p18 proteins of HIV-1, mixtures of antibodies which bind with p12, p15, p18, p25, p36, p42, and p80 proteins of HIV-1, mixtures of antibodies which bind with immune complexes comprising the HIV-1 proteins, immune complexes comprising p12 or p18 proteins of HIV-1, and methods for production of antibodies against p2 or p18 proteins of HIV-1.
摘要翻译： 本发明提供了与人免疫缺陷病毒1型（HIV-1）的p12和p18蛋白结合的抗体，其与包含HIV-1的p12或p18蛋白的免疫复合物结合的抗体，与p12，p15结合的抗体混合物， HIV-1的p18，p25，p36，p42和p80蛋白，与包含HIV-1蛋白的免疫复合物结合的抗体的混合物，包含HIV-1的p12或p18蛋白的免疫复合物，以及用于产生针对 p2或p18蛋白。
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