Invention Grant
US06210873B1 Methods and compositions for the priming of specific cytotoxic T-lymphocyte response
失效
用于引发特异性细胞毒性T淋巴细胞反应的方法和组合物
- Patent Title: Methods and compositions for the priming of specific cytotoxic T-lymphocyte response
- Patent Title (中): 用于引发特异性细胞毒性T淋巴细胞反应的方法和组合物
-
Application No.: US07800932Application Date: 1991-12-02
-
Publication No.: US06210873B1Publication Date: 2001-04-03
- Inventor: Jagannadha K. Sastry , Ralph B. Arlinghaus , Chris D. Platsoucas
- Applicant: Jagannadha K. Sastry , Ralph B. Arlinghaus , Chris D. Platsoucas
- Main IPC: C12Q170
- IPC: C12Q170
Abstract:
The present invention discloses a novel method for the rapid screening of candidate cytotoxic T lymphocyte- (CTL-) inducing compounds, such as peptides, by the in vivo priming of CTLs with synthetic peptides. The use of compounds so identified for the development of CTL vaccines for the treatment of various infectious disorders, including the treatment of viral diseases such as AIDS, herpes, influenza, and feline or bovine leukemia, is also disclosed, as is the use of this methodology for the preparation of specifically primed CTLs.
Information query
