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    Assay for directly detecting a RS virus related biological cell in a body fluid sample
    53.
    发明授权
    Assay for directly detecting a RS virus related biological cell in a body fluid sample 失效
    用于直接检测体液样品中与病毒相关的生物细胞的测定

    公开(公告)号：US06790611B2

    公开(公告)日：2004-09-14

    申请号：US09978272

    申请日：2001-10-17

    申请人： Michael Rud Lassen ,  Morten Breindahl

    发明人： Michael Rud Lassen ,  Morten Breindahl

    IPC分类号： C12Q170

    CPC分类号： G01N33/56983 ,  G01N2333/135

    摘要： The present invention relates to a kit and an assay method for rapidly and directly detecting a predetermined respiratory syncytial virus-related biological cell in a sample, even when present in an amount of less than about 2000 cells per microliter. In a preferred embodiment, a labeled antibody targets a nucleoprotein or a glycoprotein of RS virus. One may further detect an inflammatory indicator in the sample.

    摘要翻译： 本发明涉及用于快速和直接检测样品中预定呼吸道合胞病毒相关生物细胞的试剂盒和测定方法，即使以小于约2000个细胞/微升的量存在。 在优选的实施方案中，标记的抗体靶向RS病毒的核蛋白或糖蛋白。 可以进一步检测样品中的炎性指示剂。

    Methods for the treatment of cellular proliferative disorders
    54.
    发明申请
    Methods for the treatment of cellular proliferative disorders 有权
    治疗细胞增殖性疾病的方法

    公开(公告)号：US20020086284A1

    公开(公告)日：2002-07-04

    申请号：US09985756

    申请日：2001-11-06

    发明人： Matthew C. Coffey

    IPC分类号： C12Q001/70 ,  G01N033/574

    CPC分类号： G01N33/6872 ,  A61K35/765 ,  A61K45/06 ,  C12N2720/12232 ,  C12Q1/485 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57496 ,  G01N2333/135 ,  G01N2333/14 ,  A61K2300/00

    摘要： The present invention relates to methods of identifying the susceptibility of cells to reovirus infection by measuring constitutive ras-MAP signaling. The invention also pertains to methods using reovirus for the treatment of cellular proliferative disorders, and particularly cellular proliferative disorders wherein the proliferating cells exhibit constitutive MAPK phosphorylation, in mammals. In particular, the methods provide for reovirus treatment of mammals to treat proliferative disorders which include breast tumors, a subset of tumors in which mutation of the ras gene is not believed to play a significant role.

    摘要翻译： 本发明涉及通过测量组成型ras-MAP信号来鉴定细胞对呼肠孤病毒感染的易感性的方法。 本发明还涉及使用呼肠孤病毒治疗细胞增殖性疾病的方法，特别是哺乳动物中增殖细胞表现出组成型MAPK磷酸化的细胞增殖性疾病。 特别地，所述方法提供了呼肠孤病毒治疗哺乳动物以治疗增殖性疾病，包括乳腺肿瘤，其中ras基因的突变不被认为起重要作用的肿瘤的子集。

    Chimeric immunogens
    55.
    发明授权
    Chimeric immunogens 失效
    嵌合免疫原

    公开(公告)号：US06168786A

    公开(公告)日：2001-01-02

    申请号：US08467969

    申请日：1995-06-06

    申请人： Michel H. Klein ,  Run-Pan Du ,  Mary E. Ewasyshyn

    发明人： Michel H. Klein ,  Run-Pan Du ,  Mary E. Ewasyshyn

    IPC分类号： A01N6300

    CPC分类号： G01N33/56983 ,  A61K39/00 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/40 ,  C12N2760/18522 ,  C12N2760/18622 ,  G01N2333/115 ,  G01N2333/135

    摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.

    摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。

    TEST REAGENT WITH IMPROVED SPECIFICITY BY SUPPRESSING FALSE NEGATIVES
    57.
    发明公开
    TEST REAGENT WITH IMPROVED SPECIFICITY BY SUPPRESSING FALSE NEGATIVES 审中-公开

    公开(公告)号：US20240027442A1

    公开(公告)日：2024-01-25

    申请号：US18021514

    申请日：2021-09-08

    申请人： Denka Company Limited

    发明人： Yuki SHINOHARA ,  Ai SATO

    IPC分类号： G01N33/543 ,  G01N33/569 ,  C07C69/612 ,  C07C69/78 ,  C07C233/83 ,  C07C271/22

    CPC分类号： G01N33/54393 ,  G01N33/56983 ,  C07C69/612 ,  C07C69/78 ,  C07C233/83 ,  C07C271/22 ,  G01N2333/11 ,  G01N2333/135 ,  G01N2469/10

    摘要： This invention relates to a specimen-extracting solution containing a component capable of strongly suppressing false negatives, which could not be suppressed by conventional techniques, a method for extracting specimens, and a test reagent using such specimen-extracting solution and such method, when detecting virus, bacteria, target protein, or other antigens from specimens derived from body fluids, such as nasal swab specimens, nasal aspirate specimens, nasal wash specimens, nasal secretion specimens collected by nose blowing, pharyngeal swab specimens, saliva specimens, fecal specimens, serum specimens, plasma specimens, and urine specimens, with the use of a detection reagent utilizing the antigen-antibody reactions or the reactions between substances interactive with each other. The specimen-extracting solution as a constitutional unit of the test reagent or a member brought into contact with the specimens in a step performed before the detection reaction or a step performed simultaneously with the detection reaction is supplemented with a water-soluble compound comprising a phenyl, benzyl, tolyl, or xylyl group and, bound thereto, at least a carboxyl group, a functional group comprising methylated/ethylated atoms thereof, or a hydroxyl group.