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公开(公告)号：US07514535B2
公开(公告)日：2009-04-07
申请号：US11808807
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： C07K1/00
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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公开(公告)号：US20080312412A1
公开(公告)日：2008-12-18
申请号：US11808789
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： C07K14/00
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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公开(公告)号：US07671186B2
公开(公告)日：2010-03-02
申请号：US11808794
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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公开(公告)号：US20080311624A1
公开(公告)日：2008-12-18
申请号：US11808794
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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5.发明授权Multimeric hybrid gene encoding a chimeric protein which confers protection against parainfluenza virus and respiratory synctial virus 失效编码嵌合蛋白的多聚体杂交基因，其赋予对副流感病毒和呼吸道合成病毒的保护公开(公告)号：US06225091B1
公开(公告)日：2001-05-01
申请号：US08001554
申请日：1993-01-06
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： C12P2106
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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6.发明授权Multimeric hybrid gene encoding a chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus 失效编码嵌合蛋白的多聚体杂交基因，其赋予对副流感病毒和呼吸道合胞病毒的保护
公开(公告)号：US5998169A
公开(公告)日：1999-12-07
申请号：US838189
申请日：1997-04-16
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： A61K39/00 , A61K39/155 , A61K39/295 , A61P11/00 , A61P31/12 , A61P31/16 , A61P37/04 , C07K1/22 , C07K14/005 , C07K14/11 , C07K14/115 , C07K14/135 , C07K14/19 , C07K14/195 , C07K14/41 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/33 , C12N15/45 , G01N33/53 , G01N33/569 , C12N21/06 , C12N1/20 , C12N15/00 , C07N21/04
CPC分类号： G01N33/56983 , C07K14/005 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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公开(公告)号：US5968776A
公开(公告)日：1999-10-19
申请号：US467963
申请日：1995-06-06
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： A61K39/00 , A61K39/155 , A61K39/295 , A61P11/00 , A61P31/12 , A61P31/16 , A61P37/04 , C07K1/22 , C07K14/005 , C07K14/11 , C07K14/115 , C07K14/135 , C07K14/19 , C07K14/195 , C07K14/41 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/10 , C12N15/33 , C12N15/45 , G01N33/53 , G01N33/569 , C12P21/06 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： G01N33/56983 , C07K14/005 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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公开(公告)号：US07619063B2
公开(公告)日：2009-11-17
申请号：US11808789
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： C07K1/00
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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公开(公告)号：US07405273B2
公开(公告)日：2008-07-29
申请号：US11808800
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： C07K14/00
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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公开(公告)号：US06168786A
公开(公告)日：2001-01-02
申请号：US08467969
申请日：1995-06-06
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
IPC分类号： A01N6300
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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