- 专利标题： Multimeric hybrid gene encoding a chimeric protein which confers protection against parainfluenza virus and respiratory syncytial virus
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申请号： US467963申请日： 1995-06-06
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公开(公告)号： US5968776A公开(公告)日： 1999-10-19
- 发明人: Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
- 申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
- 申请人地址： CAX North York
- 专利权人： Connaught Laboratories Limited
- 当前专利权人： Connaught Laboratories Limited
- 当前专利权人地址： CAX North York
- 优先权： GBX9200117 19920106
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/155 ; A61K39/295 ; A61P11/00 ; A61P31/12 ; A61P31/16 ; A61P37/04 ; C07K1/22 ; C07K14/005 ; C07K14/11 ; C07K14/115 ; C07K14/135 ; C07K14/19 ; C07K14/195 ; C07K14/41 ; C07K19/00 ; C12N5/10 ; C12N15/09 ; C12N15/10 ; C12N15/33 ; C12N15/45 ; G01N33/53 ; G01N33/569 ; C12P21/06 ; C07H21/04 ; C12N1/20 ; C12N15/00
摘要：
Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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