公开(公告)号：US10144749B2

公开(公告)日：2018-12-04

申请号：US15993163

申请日：2018-05-30

申请人： KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS ,  KING SAUD UNIVERSITY

发明人： Said S. Al-Jaroudi ,  Ali Alhoshani ,  Muhammad Altaf ,  Anvarhusein Abdulkadir Isab

IPC分类号： A61K31/66 ,  C07F9/50 ,  A61K45/06 ,  G01N33/574 ,  C12Q1/68 ,  A61K9/00 ,  C12Q1/6886

摘要： Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

公开(公告)号：US20180269411A1

公开(公告)日：2018-09-20

申请号：US15985120

申请日：2018-05-21

申请人： Merck Patent GmbH

发明人： Philipp Stoessel ,  Dominik Joosten ,  Arne Buesing

IPC分类号： H01L51/00 ,  H05B33/14 ,  C07C211/58 ,  C07C211/61 ,  C07D209/56 ,  C07D209/80 ,  C07D209/86 ,  C07C13/62 ,  C09K11/06 ,  C09B57/10 ,  C09B57/00 ,  C09B1/00 ,  C07F15/00 ,  C07F9/58 ,  C07F9/53 ,  C07F9/50 ,  C07F7/08 ,  C07F7/02 ,  C07F5/02 ,  C07D409/14 ,  C07D409/10 ,  C07D409/04 ,  C07D405/14 ,  C07D405/10 ,  C07D403/14 ,  C07D403/04 ,  C07D401/10 ,  C07D333/76 ,  C07D333/50 ,  C07D313/06 ,  C07D307/91 ,  C07D307/77 ,  C07D251/24 ,  C07D213/53 ,  C07D209/90

CPC分类号： H01L51/0094 ,  C07C13/62 ,  C07C211/58 ,  C07C211/61 ,  C07D209/56 ,  C07D209/80 ,  C07D209/86 ,  C07D209/90 ,  C07D213/53 ,  C07D251/24 ,  C07D307/77 ,  C07D307/91 ,  C07D313/06 ,  C07D333/50 ,  C07D333/76 ,  C07D401/10 ,  C07D403/04 ,  C07D403/14 ,  C07D405/10 ,  C07D405/14 ,  C07D409/04 ,  C07D409/10 ,  C07D409/14 ,  C07F5/027 ,  C07F7/025 ,  C07F7/0807 ,  C07F7/0812 ,  C07F9/5022 ,  C07F9/5325 ,  C07F9/58 ,  C07F15/0033 ,  C07F15/0086 ,  C09B1/00 ,  C09B57/00 ,  C09B57/001 ,  C09B57/007 ,  C09B57/008 ,  C09B57/10 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1433 ,  C09K2211/145 ,  C09K2211/1458 ,  C09K2211/1491 ,  H01L51/0056 ,  H01L51/0061 ,  H01L51/0072 ,  H01L51/0074 ,  H05B33/14 ,  Y02E10/549

摘要： The present invention relates to compounds of the formula (1) and (2) which are suitable for use in electro¬nic devices, in particular organic electroluminescent devices.

公开(公告)号：US10077280B2

公开(公告)日：2018-09-18

申请号：US15351585

申请日：2016-11-15

申请人： KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS ,  KING SAUD UNIVERSITY

发明人： Said S. Al-Jaroudi ,  Ali Alhoshani ,  Muhammad Altaf ,  Anvarhusein Abdulkadir Isab

IPC分类号： A61K31/66 ,  C07F9/50 ,  A61K45/06 ,  G01N33/574 ,  C12Q1/68 ,  A61K9/00 ,  C12Q1/6886

CPC分类号： C07F9/5045 ,  A61K9/0053 ,  A61K31/66 ,  A61K45/06 ,  A61N1/30 ,  C12Q1/6886 ,  C12Q2600/156 ,  G01N33/57415 ,  G01N2800/52

摘要： Gold(I) complex with mixed ligands as an anticancer agent. The gold(I) ion is coordinated to a dithiocarbamate ligand and a phosphorus-containing ligand (e.g. phosphines). Also described are a pharmaceutical composition incorporating the gold(I) complex, a methods of synthesizing the gold(I) complex, and a method for treating cancer.

公开(公告)号：US10072033B2

公开(公告)日：2018-09-11

申请号：US15502813

申请日：2015-08-26

申请人： TAKASAGO INTERNATIONAL CORPORATION

发明人： Yuji Nakayama ,  Osamu Ogata

IPC分类号： C07F15/00 ,  C07F9/50

CPC分类号： C07F9/5022 ,  C07F9/5018 ,  C07F9/5077 ,  C07F9/653 ,  C07F15/0046 ,  C07F15/0053

摘要： The purpose of the present invention is to provide: a ligand that is useful in a catalytic organic synthetic reaction; a method for producing said ligand; and a metal complex that is useful as a catalyst in an organic synthetic reaction. The present invention provides a compound represented by general formula (1A), a method for producing said compound, and a metal complex including said compound as a ligand. (In the formula, H, N, P, S, L, R1, R2, R3, Q1, and Q2 have the meaning as defined in the Description.)

公开(公告)号：US10059729B2

公开(公告)日：2018-08-28

申请号：US15306671

申请日：2015-04-24

申请人： Takasago International Corporation

发明人： Osamu Ogata ,  Hideki Nara ,  Yuji Nakayama

IPC分类号： C07F15/00 ,  B01J31/24 ,  B01J31/22 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C29/149 ,  C07C31/20 ,  C07C33/22 ,  C07F9/50 ,  C07C209/18 ,  C07C45/29 ,  C07F19/00 ,  C07C211/48 ,  C07C49/78 ,  C07D213/30 ,  C07B61/00

CPC分类号： C07F15/0046 ,  B01J31/22 ,  B01J31/24 ,  B01J31/2409 ,  B01J2231/643 ,  B01J2231/70 ,  B01J2531/0216 ,  B01J2531/821 ,  C07B61/00 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C29/149 ,  C07C31/20 ,  C07C33/22 ,  C07C45/29 ,  C07C49/78 ,  C07C209/18 ,  C07C211/48 ,  C07D213/30 ,  C07F9/50 ,  C07F15/00 ,  C07F19/00

摘要： The present invention provides a novel ruthenium complex that is easy to produce and handle and that can be supplied relatively inexpensively, a method for producing this ruthenium complex, a method for producing alcohols and the like using this ruthenium complex as a catalyst, a method for producing carbonyl compounds using this ruthenium complex as a catalyst, and a method for producing N-alkylamine compounds using this ruthenium complex as a catalyst. The present invention pertains to a ruthenium complex represented by general formula (1) RuX1X2(PNP) (NHC)m(Solv)n(1) (in general formula (1), X1 and X2 each independently represent a monovalent anionic monodentate ligand; PNP represents a tridentate aminodiphosphine ligand, NHC represents an N-heterocyclic carbene derived from a nitrogen-containing heterocyclic ring, and Solv represents a coordinating solvent; and m represents an integer from 1 to 3, n represents an integer from 0 to 2, and 1≤m+n≤3.), a method for producing the same, a catalyst including the same, and methods for producing various organic compounds using this catalyst.

公开(公告)号：US10053475B2

公开(公告)日：2018-08-21

申请号：US15105927

申请日：2014-12-10

申请人： Firmenich SA

发明人： Julie Quintaine ,  Lionel Saudan

IPC分类号： C07C29/141 ,  C07C29/145 ,  C07C29/149 ,  B01J31/24 ,  C07F9/50 ,  C07F9/58 ,  C07F15/02

CPC分类号： C07F9/5045 ,  B01J31/24 ,  B01J2231/641 ,  B01J2531/842 ,  C07C29/141 ,  C07C29/145 ,  C07C29/149 ,  C07F9/5004 ,  C07F9/5018 ,  C07F9/5022 ,  C07F9/58 ,  C07F15/02 ,  C07C33/025 ,  C07C33/22 ,  C07C31/125 ,  C07C33/14 ,  C07C35/08 ,  C07C35/18

摘要： The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of Fe complexes with tridentate ligands, having one amino or imino coordinating group and two phosphino coordinating groups, in hydrogenation processes for the reduction of ketones, aldehydes, esters or lactones into the corresponding alcohol or diol, respectively.

公开(公告)号：US20180216008A1

公开(公告)日：2018-08-02

申请号：US15128775

申请日：2015-03-24

申请人： BASF SE

发明人： Roland H. KRÃMER ,  Peter DEGLMANN ,  Alexander KÖNIG ,  Rebekka VON BENTEN ,  Andrea EISENHARDT ,  Sindhu MENON ,  Frank REUTER ,  Hansjörg GRÜTZMACHER ,  Aaron TONDREAU

IPC分类号： C09K21/12 ,  C09K21/10 ,  C08K5/5425 ,  C08K5/50 ,  C08K5/3437 ,  C07F9/50

CPC分类号： C09K21/12 ,  C01B25/06 ,  C07F9/504 ,  C07F9/6568 ,  C08K3/32 ,  C08K5/3437 ,  C08K5/34922 ,  C08K5/50 ,  C08K5/5406 ,  C08K5/5425 ,  C09K21/10

摘要： The invention relates to flame retardant compositions comprising heptaphosphorus-derived compounds and to novel heptaphosphorus-derived compounds.These heptaphosphorus-derived compounds are especially useful for the manufacture of flame retardant compositions based on thermoplastic polymers, especially polyolefin homo- and copolymers, polycondensates, such as polyamides, or polyesters and duro-plastic polymers, such as the ones based on polyepoxides.

公开(公告)号：US20180193476A1

公开(公告)日：2018-07-12

申请号：US15702586

申请日：2017-09-12

申请人： Innate Pharma ,  Paul Scherrer Institut

发明人： Patrick Dennler ,  Delphine Bregeon ,  Laurent Gauthier ,  François Romagné ,  Christian Belmant ,  Eliane Fischer ,  Roger Schibli

IPC分类号： A61K47/68 ,  G01N33/68 ,  C12N9/10 ,  C12P21/00 ,  C07K19/00 ,  C07K16/00 ,  C07F9/50 ,  C07D277/06 ,  C07D257/08 ,  C07D225/08 ,  C07C323/60 ,  C07C323/12 ,  C07C247/04 ,  C07C233/62 ,  C07C229/26 ,  C07C223/02 ,  C07C217/08

摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.

公开(公告)号：US20180079741A1

公开(公告)日：2018-03-22

申请号：US15786953

申请日：2017-10-18

申请人： Takeda Pharmaceuticals Company Limited

发明人： Masatoshi Yamada ,  Sayuri Hirano ,  Ryoji Tsuruoka ,  Mitsuhisa Yamano

IPC分类号： C07D401/04 ,  C07F17/02 ,  B01J31/22 ,  C07F9/50 ,  C07D211/78 ,  C07D211/60 ,  C07F15/00 ,  B01J31/24

CPC分类号： C07D401/04 ,  B01J31/2226 ,  B01J31/2295 ,  B01J31/2409 ,  B01J31/2452 ,  B01J2231/645 ,  B01J2531/0205 ,  B01J2531/0263 ,  B01J2531/0266 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/827 ,  B01J2531/842 ,  B01J2540/225 ,  C07B2200/07 ,  C07D211/60 ,  C07D211/78 ,  C07F9/5027 ,  C07F15/0046 ,  C07F17/02

摘要： The present invention provides a method of efficiently producing an optically active 6-(3-aminopiperidin-1-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidine derivative. The optically active piperidine-3-carboxamide or a derivative thereof, which is obtained by subjecting 1,4,5,6-tetrahydropyridine-3-carboxamide or a derivative thereof to an asymmetric reduction in the presence of a catalyst, is used as an intermediate.

公开(公告)号：US20180071402A1

公开(公告)日：2018-03-15

申请号：US15654585

申请日：2017-07-19

申请人： Innate Pharma ,  Paul Scherrer Institut

发明人： Delphine Bregeon ,  Patrick Dennler ,  Christian Belmant ,  Eliane Fischer ,  Laurent Gauthier ,  Francois Romagné ,  Roger Schibli

IPC分类号： G01N33/68 ,  C12N9/10 ,  C12P21/00 ,  C07K19/00 ,  C07K16/00 ,  C07F9/50 ,  C07D277/06 ,  C07D257/08 ,  C07D225/08 ,  C07C323/60 ,  C07C323/12 ,  C07C247/04 ,  C07C233/62 ,  C07C229/26 ,  C07C223/02 ,  C07C217/08

CPC分类号： A61K47/6803 ,  A61K47/60 ,  A61K47/68 ,  A61K47/6807 ,  A61K47/6813 ,  A61K47/6817 ,  A61K47/6865 ,  A61K47/6871 ,  C07C217/08 ,  C07C223/02 ,  C07C229/26 ,  C07C233/62 ,  C07C247/04 ,  C07C323/12 ,  C07C323/60 ,  C07D225/08 ,  C07D257/08 ,  C07D277/06 ,  C07F9/5022 ,  C07K16/00 ,  C07K19/00 ,  C07K2317/40 ,  C12N9/1044 ,  C12P21/005 ,  G01N33/6854

摘要： The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.