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公开(公告)号：US12234566B2
公开(公告)日：2025-02-25
申请号：US17612018
申请日：2020-05-13
Applicant: Paul Scherrer Institut
Inventor： Lorenz Gubler , Ugljesa Babic , Thomas Justus Schmidt , Steffen Garbe
Abstract: A method of preparing an ionomer of an ion exchange membrane with a recombination catalyst to prevent gas crossover of species, such as hydrogen and/or oxygen, to anodic and cathodic cell compartments of an electrochemical cell. An ionomer of an ion exchange membrane is prepared with a recombination catalyst. The ionomer is a proton or anion exchange polymer and the recombination catalyst, selected from the precious metals group, is provided in ionic form in a liquid metal salt solution. The ion exchange membrane is immersed into the liquid metal salt solution to exchange ionic ionomer ports with the ionic form of the recombination catalyst. The membrane is then assembled in the electrochemical cell and the ionic form of the recombination catalyst is at least partly reduced to metallic form by forcing hydrogen to permeate through the ionomer of the ion exchange membrane.
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公开(公告)号：US20240139742A1
公开(公告)日：2024-05-02
申请号：US18559099
申请日：2022-05-02
Applicant: Paul Scherrer Institut
Inventor： Thomas Mortelmans , Yasin Ekinci , Xiaodan Li
IPC: B01L3/00 , G01N33/543
CPC classification number: B01L3/502761 , G01N33/54366 , B01L2400/0406
Abstract: The planetary outbreak of COVID-19 has led to a substantial death toll and has hindered the functioning of modern society. This underlines the importance of accurate, cost-effective serological antibody tests and point-of-care diagnostics to monitor the viral spread and to contain pandemics and endemics. This requires a cost-effective three-dimensional nanofluidic device for rapid and multiplexed detection of viral antibodies. The device is configured to size-dependently immobilize particles at predefined positions from a multiparticle mixture, giving rise to distinct trapping lines. It is shown with the device that distinctive lines can be used as an on-chip and on-bead fluorescent linked immunosorbent assay for the detection of immunoglobulin G (IgG) antibodies against the receptor-binding domain of SARS-CoV-2 in human serum. Device versatility is exhibited by on-bead color multiplexing for simultaneous detection of IgG and IgM in convalescent human serum and by concurrent detection of anti-spike (SARS-CoV-2) and anti-hemagglutinin (Influenza A) antibodies.
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公开(公告)号：US11933746B2
公开(公告)日：2024-03-19
申请号：US17781098
申请日：2020-11-16
Applicant: Paul Scherrer Institut
Inventor： Soichiro Tsujino , Takashi Tomizaki , Michal Kepa
IPC: G01N23/20 , G01N23/20016 , G01N23/20025 , G01N23/205
CPC classification number: G01N23/20025 , G01N23/20016 , G01N23/205 , G01N2223/0561 , G01N2223/307 , G01N2223/309 , G01N2223/321 , G01N2223/3306 , G01N2223/40 , G01N2223/501 , G01N2223/602
Abstract: A device to host a crystallization medium, such as a solution, for crystal growth and a system for X-ray diffraction experiments to determine the atomic structure of crystals. A plurality of cells have a well, a sample holder placed in the well. The solution is hosted in the sample holder between thin-plates or one thin-plate. A cap seals an opening to the cell and each sample holder can be extracted independently from each well. A system for automated X-ray diffraction experiments for small crystals in the sample holder extracted from the wells utilizes an ultrasonic acoustic levitator to determine the crystal structure at atomic resolution. X-ray diffraction images are generated by scanning the X-ray beam over the levitated sample holder along a spiral trajectory by rotating the sample holder and moving in the direction perpendicular to the X-ray beam and the rotation axis at the same time.
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公开(公告)号：US20230299263A1
公开(公告)日：2023-09-21
申请号：US18041571
申请日：2021-07-21
Applicant: Paul Scherrer Institut
Inventor： Ales Stefancic , Mario El Kazzi
CPC classification number: H01M4/0471 , H01M4/382 , H01M4/525 , H01M4/485
Abstract: A method uses mild fluorinating agents, such as hydrofluorocarbons—HCFs, perfluorocarbons—PFCs, hydrochlorofluorocarbons HCFCs and chlorofluorocarbons—CFCs, to fine-tune the fluorination process in battery material preparation in order to obtain uniform nanometer-sized surface fluoride coated battery materials. The use of a vertical flow-type tube reactor permits a fine-tuning of the fluorination process by accurately regulating the active gas or mixture of gases flow over battery materials using mass-flow regulators, and precisely setting the temperature with vertical rube furnace. Additionally, these fluorinating agents have slightly different reactivity, decomposing and reacting with battery materials at different temperatures, and therefore, offering additional parameter of fluorination fine-tuning. The method is scalable and can be easily adapted as an industrial solution. Moreover, all these gases are non-toxic, non-corrosive and non-flammable gases at room temperatures, hence, they are more convenient to handle than highly-toxic and highly-corrosive HF and F2 gases.
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公开(公告)号：US20230297870A1
公开(公告)日：2023-09-21
申请号：US18041575
申请日：2021-07-29
Applicant: Paul Scherrer Institut
Inventor： Gabriel Aeppli , Markus Müller , Manuel Grimm , Adrian Beckert
IPC: G06N10/40
CPC classification number: G06N10/40
Abstract: A universal quantum computing system uses electro-nuclear wavefunctions of rare-earth ions embedded in an insulating solid state matrix. Each rare-earth ion represents a nuclear qubit that can be selectively operated as a passive or active qubit. The passive qubit is a passive electronic doublet at a non-degenerate ground state that stores the quantum information in the two different nuclear spin states possible in the non-degenerate ground state causing two different passive-state electro-nuclear wavefunctions. The active qubit is an active electronic doublet at a non-degenerate excited state that stores the quantum information in the two different nuclear spin states possible in the non-degenerate excited state. A laser source generates laser pulses to optically excite the rare-earth ions from the non-degenerate ground state into the non-degenerate excited state and vice versa, to locally control the electronic dipolar interaction in a tunable manner among at least two active qubits.
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Patent Agency Ranking
公开(公告)号：US20230235289A1
公开(公告)日：2023-07-27
申请号：US17918981
申请日：2021-03-30
Applicant: Paul Scherrer Institut
Inventor： G.V. Shivashankar , Bibhas Roy
IPC: C12N5/077
CPC classification number: C12N5/0656 , C12N2506/1307 , C12N2527/00 , C12N2533/52 , C12N2533/54 , C12N2535/10
Abstract: Over the course of an aging process fibroblasts lose contractility, leading to reduced connective tissue stiffness. A promising therapeutic avenue for functional rejuvenation of connective tissue is reprogrammed fibroblast replacements with a laterally confined growth of fibroblasts on micro-patterned substrates that induces stem cell-like spheroids. The partially reprogrammed spheroids are embedded in collagen-I matrices of varying densities, mimicking different 3D tissue constraints. The spheroids regain their fibroblastic properties and sprout to form 3D connective tissue networks. The differentiated fibroblasts exhibit reduced DNA damage, enhanced cytoskeletal gene expression and acto-myosin contractility. The rejuvenated fibroblasts show increased matrix protein (fibronectin and laminin) deposition and collagen remodeling compared to the parental fibroblast tissue network. The partially reprogrammed cells have comparatively open chromatin compaction states and may be more poised to redifferentiation into contractile fibroblasts in 3D-collagen matrix. Collectively, the results highlight efficient fibroblast rejuvenation, with important implications in regenerative medicine.
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公开(公告)号：US20230212228A1
公开(公告)日：2023-07-06
申请号：US17938092
申请日：2022-10-05
Applicant: ETH Zürich , Paul Scherrer Institut
Inventor： Viola VOGEL , Mamta CHABRIA , Giulia VALPREDA , Belinda TRACHSEL , Martin BEHE
CPC classification number: C07K14/001 , A61P11/00 , A61P35/00 , G01N33/68
Abstract: The present invention relates to fibronectin-binding peptides according to the sequence
FnI5BS-L1-FnI4BS-L2-FnI3BS-L3-FnI2BS
which are useful in tumor or fibrosis diagnosis and therapy. Instant peptides show improved fibronectin-binding and biodistribution properties compared to the prior art. Furthermore, instant peptides may be conjugated to a payload and are useful in the treatment and/or prevention of diseases associated with pathological fibronectin accumulation, including cancer and fibrosis. Instant peptides are also useful in diagnosis of diseases associated with pathological fibronectin accumulation, including cancer and fibrosis.-
公开(公告)号：US11623014B2
公开(公告)日：2023-04-11
申请号：US17127265
申请日：2020-12-18
Applicant: Paul Scherrer Institut
Inventor： Martin Behe , Roger Schibli
IPC: A61K51/08 , A61K38/22 , C07K14/575 , C07K14/595 , C07B59/00 , C07K1/13 , C07K7/08 , G01N33/574
Abstract: A gastrin analogue shows high uptake in CCK-2 receptor positive tumors and simultaneously a very low accumulation in the kidneys. This is achieved by a mini-gastrin analogue PP-F11 having the formula: PP-F11-X-DGlu-DGlu-DGlu-DGlu-DGlu-DGlu-Ala-Tyr-Gly-Trp-Y-Asp-Phe-NH2, wherein Y is an amino acid replacing methionine and X is a chemical group attached to the peptide for diagnostic and/or therapeutic intervention at CCK-2 receptor relevant diseases. Very suitable compounds with respect to a high tumor to kidney ratio are mini-gastrin analogues with six D-glutamic acids or six glutamines. These compounds still possess a methionine which can be oxidized easily which is a disadvantage for clinical application under GMP due to the forms which may occur. The elimination of the methionine leads to a lower affinity to oxidation which in general favors the tumor-kidney-ratio. Ideally, the methionine is replaced by norleucine. This PP-F11N mini gastrin exhibits currently the best tumor-kidney-ratio and is the most promising candidate.
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9.发明授权公开(公告)号：US11611084B2
公开(公告)日：2023-03-21
申请号：US16962392
申请日：2018-12-05
Applicant: PAUL SCHERRER INSTITUT
Inventor： Lorenz Gubler , Fabio J. Oldenburg , Alexander Arndt
IPC: H01M8/0228 , H01M8/1023 , H01M8/1041 , H01M8/1086 , H01M8/18
Abstract: An electrolyte membrane and method for generating the membrane provide a resistance as low as possible to minimize ohmic losses. The membrane has a low permeability for redox-active species. If redox-active species still cross the membrane, this transport is balanced during charge and discharge preventing a net vanadium flux and associated capacity fading. The membrane is mechanically robust, chemically stable in electrolyte solution, and low cost. A family of ion exchange membranes including a bilayer architecture achieves these requirements. The bilayer membrane includes two polymers, i) a polymer including N-heterocycles with electron lone pairs acting as proton acceptor sites and ii) a mechanically robust polymer acting as a support, which can be a dense cation exchange membrane or porous support layer. This bilayer architecture permits a very thin polymer film on a supporting polymer to minimize ohmic resistance and tune electrolyte transport properties of the membrane.
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公开(公告)号：US20220404296A1
公开(公告)日：2022-12-22
申请号：US17781098
申请日：2020-11-16
Applicant: Paul Scherrer Institut
Inventor： Soichiro Tsujino , Takashi Tomizaki
IPC: G01N23/20025 , G01N23/20016 , G01N23/205
Abstract: A device to host a crystallization medium, such as a solution, for crystal growth and a system for X-ray diffraction experiments to determine the atomic structure of crystals. A plurality of cells have a well, a sample holder placed in the well. The solution is hosted in the sample holder between thin-plates or one thin-plate. A cap seals an opening to the cell and each sample holder can be extracted independently from each well. A system for automated X-ray diffraction experiments for small crystals in the sample holder extracted from the wells utilizes an ultrasonic acoustic levitator to determine the crystal structure at atomic resolution. X-ray diffraction images are generated by scanning the X-ray beam over the levitated sample holder along a spiral trajectory by rotating the sample holder and moving in the direction perpendicular to the X-ray beam and the rotation axis at the same time.
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