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    SYSTEM AND METHOD FOR THE DECONVOLUTION OF MIXED DNA PROFILES USING A PROPORTIONATELY SHARED ALLELE APPROACH
    33.
    发明申请
    SYSTEM AND METHOD FOR THE DECONVOLUTION OF MIXED DNA PROFILES USING A PROPORTIONATELY SHARED ALLELE APPROACH 审中-公开
    使用比例共享方法解码混合DNA谱图的系统和方法

    公开(公告)号：US20090270264A1

    公开(公告)日：2009-10-29

    申请号：US12421124

    申请日：2009-04-09

    申请人： Thomas L. Overson

    发明人： Thomas L. Overson

    IPC分类号： C40B20/06 ,  C40B60/10

    CPC分类号： G16B20/00 ,  C40B20/06 ,  C40B60/10

    摘要： A total forensic DNA casework management system and method for the deconvolution of mixed DNA samples using a novel, 3-rule algorithm to determine the proportional allele sharing of the sample's contributors. The process is fully document, can assess and process DNA anomalies and artifacts, and transforms raw STR data to produce final DNA profile types, peak height ratios, proportions, fitting criteria and associated graphs.

    摘要翻译： 一个全面的法医DNA个案工作管理系统和混合DNA样本的去卷积方法，采用新颖的3规则算法来确定样本贡献者的比例等位基因共享。 该过程是完整的文件，可以评估和处理DNA异常和伪像，并转换原始的STR数据，以产生最终的DNA分布类型，峰高比，比例，拟合标准和相关图。

    Detection apparatus for biological materials and methods of making and using the same
    34.
    发明申请
    Detection apparatus for biological materials and methods of making and using the same 审中-公开
    用于生物材料的检测装置及其制造和使用方法

    公开(公告)号：US20090163384A1

    公开(公告)日：2009-06-25

    申请号：US12004628

    申请日：2007-12-22

    申请人： Robert L. Willett ,  Kirk W. Baldwin ,  Loren N. Pfeiffer

    发明人： Robert L. Willett ,  Kirk W. Baldwin ,  Loren N. Pfeiffer

    IPC分类号： C40B60/10

    CPC分类号： G01N33/5438 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00443 ,  B01J2219/00533 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00702 ,  B01J2219/00725 ,  B01J2219/0075 ,  C40B60/04 ,  C40B60/10 ,  Y10T29/49117 ,  Y10T29/49155 ,  Y10T29/49826 ,  Y10T436/11

    摘要： Apparatus comprising a surface site comprising a substantially inorganic surface having a chemical composition selected from the group consisting of metals, semiconductors, insulators, and mixtures thereof, the surface positioned within a polypeptide bonding region and having a selective bonding affinity for a polypeptide; a plurality of interlayers between which the surface site is interposed; a distal site end on the surface site and distanced from the interlayers, the surface being provided on the distal site end; the surface site and the interlayers being interposed between first and second supports; first and second conductors provided on the first and second supports and having respective first and second distal conductor ends positioned within the polypeptide bonding region; the conductors being capable of applying an external voltage potential across the polypeptide bonding region. Apparatus, optionally comprising such first and second supports and conductors; and comprising a third conductor in electrical communication with the surface site, the third conductor positioned for electrical communication with a source of an external bias voltage. Techniques for making apparatus.

    摘要翻译： 包括表面位置的装置包括具有选自金属，半导体，绝缘体及其混合物的化学组成的基本无机表面，所述表面位于多肽结合区域内并且对多肽具有选择性结合亲和力; 多个中间层，其间插入表面部位; 位于表面部位的远侧位置端部并且远离中间层，所述表面设置在远端位置端部; 表面部位和夹层介于第一和第二支撑之间; 第一和第二导体，其设置在第一和第二支撑件上，并且具有位于多肽接合区域内的相应的第一和第二远端导体末端; 导体能够跨越多肽接合区域施加外部电压电位。 装置，可选地包括这样的第一和第二支撑件和导体; 并且包括与表面部位电连通的第三导体，所述第三导体定位成与外部偏置电压源电连通。 制造设备的技术。

    Combinatorial Processing Including Stirring
    35.
    发明申请
    Combinatorial Processing Including Stirring 有权
    组合加工包括搅拌

    公开(公告)号：US20080312090A1

    公开(公告)日：2008-12-18

    申请号：US11763180

    申请日：2007-06-14

    申请人： Zachary Fresco ,  Nitin Kumar

    发明人： Zachary Fresco ,  Nitin Kumar

    IPC分类号： C40B20/02 ,  C40B60/10

    CPC分类号： B01J19/0046 ,  B01J2219/00333 ,  B01J2219/00364 ,  B01J2219/00389 ,  B01J2219/00481 ,  B01J2219/00527 ,  B01J2219/00596 ,  B01J2219/00756

    摘要： Combinatorial processing including stirring is described, including defining multiple regions of a substrate, processing the multiple regions of the substrate in a combinatorial manner, introducing a fluid into a first aperture at a first end of a body to dispense the fluid out of a second aperture at a second end of the body and into one of the multiple regions, and agitating the fluid using an impeller at a second end of the body to facilitate interaction of the fluid with a surface of the substrate.

    摘要翻译： 描述了包括搅拌在内的组合处理，包括限定衬底的多个区域，以组合的方式处理衬底的多个区域，将流体引入到身体的第一端的第一孔中，以将流体从第二孔 在所述主体的第二端并且进入所述多个区域之一，并且在所述主体的第二端处使用叶轮来搅动所述流体，以促进所述流体与所述基板的表面的相互作用。

    Biopolymeric array scanners capable of automatic scale factor selection for a plurality of different dyes, and methods for making and using the same
    36.
    发明申请
    Biopolymeric array scanners capable of automatic scale factor selection for a plurality of different dyes, and methods for making and using the same 审中-公开

    公开(公告)号：US20080161206A1

    公开(公告)日：2008-07-03

    申请号：US12005542

    申请日：2007-12-26

    申请人： John F. Corson ,  Scott D. Connell ,  Srinka Ghosh

    发明人： John F. Corson ,  Scott D. Connell ,  Srinka Ghosh

    IPC分类号： C40B60/10 ,  G01N33/50

    CPC分类号： G01N21/6452 ,  G01N21/6428 ,  G01N2201/1241

    摘要： Biopolymeric array scanners that are capable of automatically selecting a dye specific scale factor to employ for a plurality of different dyes, as wells as methods for making and using the same, are provided. In many embodiments, the actual dye specific scale factor automatically selected by the scanner is one that is equal to a preset “master” scale factor, so that the scanner reads any supported dye using the same constant scale factor. The dye specific scale factor selection is typically made by reference to a collection of nominal scale factors for each member of the plurality of dyes. In using the subject scanners, a user simply inputs the one or more dyes being used in a given array assay, and the scanner automatically reads the array using an automatically chosen dye specific scale factor for the selected dyes. Also provided are methods of obtaining collections of nominal scale factors and computer readable mediums comprising the same. The subject invention finds use in a variety of different applications, including both genomics and proteomics applications.

    Conductimetric biosensor device, method and system
    37.
    发明申请
    Conductimetric biosensor device, method and system 审中-公开
    电导生物传感器装置，方法和系统

    公开(公告)号：US20080108517A1

    公开(公告)日：2008-05-08

    申请号：US11986414

    申请日：2007-11-21

    申请人： Evangelyn Alocilja ,  Zarini Muhammad-Tahir

    发明人： Evangelyn Alocilja ,  Zarini Muhammad-Tahir

    IPC分类号： C40B60/10 ,  C12M1/34

    CPC分类号： G01N33/5438

    摘要： A multi-array membrane strip biosensor device (10, 20) using a fluid mobile conductive polymer as reporter is described. The biosensor device (20) is designed to detect multiple analytes at low concentrations in near real-time with an electronic data collection system. The biosensor device can be small. The device can be used to detect pathogens, proteins, and other biological materials of interest in food, water, and environmental samples. The device can also be used for on-site diagnosis and against potential bioterrorism. Potential users include food processing plants, meat packaging facilities, fruit and vegetable packers, restaurants, food and water safety inspectors, food wholesalers and retailers, farms, homes, medical profession, import border crossing personnel, and the police force, military, space habitation and national security.

    摘要翻译： 描述了使用流体移动导电聚合物作为报告物的多阵列膜条生物传感器装置（10,20）。 生物传感器装置（20）被设计成用电子数据采集系统近实时地检测低浓度的多个分析物。 生物传感器装置可以很小。 该装置可用于检测食品，水和环境样品中感兴趣的病原体，蛋白质和其他生物材料。 该设备还可用于现场诊断和潜在的生物恐怖。 潜在用户包括食品加工厂，肉类包装设备，水果和蔬菜包装机，餐饮，食品和水安全检查员，食品批发商和零售商，农场，住房，医疗专业，进口过境人员以及警察部队，军事，太空人居 和国家安全。

    Microscale fluidic devices for electrochemical detection of biological molecules
    38.
    发明申请
    Microscale fluidic devices for electrochemical detection of biological molecules 审中-公开
    用于电化学检测生物分子的微型流体装置

    公开(公告)号：US20080103064A1

    公开(公告)日：2008-05-01

    申请号：US11808785

    申请日：2007-06-13

    申请人： Marc R. Labgold

    发明人： Marc R. Labgold

    IPC分类号： C40B60/10

    CPC分类号： C40B60/04 ,  C40B20/08 ,  C40B30/04

    摘要： The present invention provides microdevices for electrochemical detection of target agents in a fluid sample. The microdevices each comprise an elongated microstructure having an inlet for introduction of a fluid sample potentially containing a target agent, and an outlet to allow the sample to flow through the region of the microdevice that allows detection of the target agent. This detection is mediated through hybridization of nucleic acids corresponding to a target agent with device-associated nucleic acids and subsequent binding of an electrochemical detection agent to allow the transfer of an electron to or from the electrode. In specific embodiment, the device comprises: a hollow elongated microstructure with a conductive surface on the internal surface; b) insulating polymer that is uniformly distributed on the conductive surface; c) adapter molecule associated with the insulating polymer, and d) a plurality of associated nucleic acids conjugated to the polymer surface in a specific orientation.

    摘要翻译： 本发明提供用于液体样品中靶物质的电化学检测的微型装置。 微型装置各自包括细长的微结构，其具有用于引入潜在地含有目标试剂的流体样品的入口和允许样品流过允许检测目标试剂的微型装置的区域的出口。 该检测通过对应于靶物质的核酸与器件相关核酸的杂交以及随后的电化学检测剂的结合以允许将电子转移到电极或从电极转移来介导。 在具体实施例中，该装置包括：在内表面上具有导电表面的中空细长微结构; b）均匀分布在导电表面上的绝缘聚合物; c）与绝缘聚合物相关的衔接子分子，和d）以特定方向与聚合物表面缀合的多个相关核酸。

    System and apparatus for automated protein analysis priority
    39.
    发明申请
    System and apparatus for automated protein analysis priority 审中-公开
    用于自动蛋白质分析的系统和设备优先

    公开(公告)号：US20080076680A1

    公开(公告)日：2008-03-27

    申请号：US11786498

    申请日：2007-04-12

    申请人： Bakshy Chibber

    发明人： Bakshy Chibber

    IPC分类号： C40B60/10

    CPC分类号： C07K1/22

    摘要： The present application relates to a system and apparatus for protein sequencing that incorporates a modular system that allows for high throughput and flexibility in the use of a detection system to provide a more robust sequencing system. In one embodiment, a sample plate containing multiple sample wells may be loaded into the apparatus and processed simultaneously using an automated chemical degradation, digestion, or ladder process resulting in multiple products that can be produced without regard to the reduction in throughput associated with conversion of eluted products.

    摘要翻译： 本申请涉及一种用于蛋白质测序的系统和装置，其包括模块化系统，其允许在检测系统的使用中提供更强大的测序系统的高吞吐量和灵活性。 在一个实施方案中，可以将含有多个样品孔的样品板加载到设备中并使用自动化学降解，消化或梯形过程同时进行处理，从而产生可以生产的多种产物，而不考虑与转化相关的生产量的降低 洗脱产物。

    Apparatus and method for the precise location of reaction plates
    40.
    发明申请
    Apparatus and method for the precise location of reaction plates 审中-公开
    反应板精确定位的装置和方法

    公开(公告)号：US20050152810A1

    公开(公告)日：2005-07-14

    申请号：US11069322

    申请日：2005-02-28

    申请人： Reid Kowallis ,  David Cox

    发明人： Reid Kowallis ,  David Cox

    IPC分类号： G01N35/02 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B20/02 ,  C40B60/10 ,  G01N35/10

    CPC分类号： B01L3/5085 ,  G01N35/1065 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/2575

    摘要： Generally, the present invention provides a device and method for accurately locating a multi-well plate at a plate-support location, e.g., a work surface, of an automated laboratory machine, such that one or more acting members of the machine, such as an array of pipette tips, optical sensors, or the like, can accurately address and operate on the individual wells. Interior and/or exterior surface regions of one or more wells of a multi-well plate are used as the primary plate features engaged by locating structure of the machine. In one particular embodiment one or more upwardly tapered projections extend from a plate-support surface of a plate-handling machine for mating engagement with the exterior surface regions of one or more wells. In another embodiment, the exterior surface regions along one or more well bottoms are engagingly received within bores, or other receiving structure, formed on the plate-support surface of a machine. In a further embodiment, one or more downwardly extending projections depend from an acting-member support, along with the acting members of a machine. Introduction of the projections into some of the wells of a multi-well plate serves to align the acting members with the plate's other wells. A biasing assembly can be used to press together the engaging surface regions of the wells and the locating structures of the machine.

    摘要翻译： 通常，本发明提供了一种用于在自动化实验室机器的板支撑位置（例如工作表面）处精确地定位多孔板的装置和方法，使得机器的一个或多个作用构件，例如 移液管尖端，光学传感器等的阵列可以精确地解决和操作各个井。 使用多孔板的一个或多个孔的内部和/或外部表面区域作为通过定位机器的结构而接合的主要板材特征。 在一个特定实施例中，一个或多个向上锥形突起从板处理机的板支撑表面延伸，用于与一个或多个井的外表面区域配合接合。 在另一个实施例中，沿着一个或多个井底的外表面区域接合地容纳在形成在机器的板支撑表面上的孔或其它接收结构内。 在另一个实施例中，一个或多个向下延伸的突起与作用构件支撑件一起，与机器的作用构件一起。 将突出物引入多孔板的一些孔中用于使作用构件与板的其它孔对齐。 偏置组件可用于将井的接合表面区域和机器的定位结构压在一起。