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    Apparatus and method for the precise location of reaction plates
    1.
    发明申请
    Apparatus and method for the precise location of reaction plates 审中-公开
    反应板精确定位的装置和方法

    公开(公告)号：US20050152810A1

    公开(公告)日：2005-07-14

    申请号：US11069322

    申请日：2005-02-28

    申请人： Reid Kowallis ,  David Cox

    发明人： Reid Kowallis ,  David Cox

    IPC分类号： G01N35/02 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B20/02 ,  C40B60/10 ,  G01N35/10

    CPC分类号： B01L3/5085 ,  G01N35/1065 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/2575

    摘要： Generally, the present invention provides a device and method for accurately locating a multi-well plate at a plate-support location, e.g., a work surface, of an automated laboratory machine, such that one or more acting members of the machine, such as an array of pipette tips, optical sensors, or the like, can accurately address and operate on the individual wells. Interior and/or exterior surface regions of one or more wells of a multi-well plate are used as the primary plate features engaged by locating structure of the machine. In one particular embodiment one or more upwardly tapered projections extend from a plate-support surface of a plate-handling machine for mating engagement with the exterior surface regions of one or more wells. In another embodiment, the exterior surface regions along one or more well bottoms are engagingly received within bores, or other receiving structure, formed on the plate-support surface of a machine. In a further embodiment, one or more downwardly extending projections depend from an acting-member support, along with the acting members of a machine. Introduction of the projections into some of the wells of a multi-well plate serves to align the acting members with the plate's other wells. A biasing assembly can be used to press together the engaging surface regions of the wells and the locating structures of the machine.

    摘要翻译： 通常，本发明提供了一种用于在自动化实验室机器的板支撑位置（例如工作表面）处精确地定位多孔板的装置和方法，使得机器的一个或多个作用构件，例如 移液管尖端，光学传感器等的阵列可以精确地解决和操作各个井。 使用多孔板的一个或多个孔的内部和/或外部表面区域作为通过定位机器的结构而接合的主要板材特征。 在一个特定实施例中，一个或多个向上锥形突起从板处理机的板支撑表面延伸，用于与一个或多个井的外表面区域配合接合。 在另一个实施例中，沿着一个或多个井底的外表面区域接合地容纳在形成在机器的板支撑表面上的孔或其它接收结构内。 在另一个实施例中，一个或多个向下延伸的突起与作用构件支撑件一起，与机器的作用构件一起。 将突出物引入多孔板的一些孔中用于使作用构件与板的其它孔对齐。 偏置组件可用于将井的接合表面区域和机器的定位结构压在一起。

    Fluid processing device comprising radial channels
    8.
    发明申请
    Fluid processing device comprising radial channels 审中-公开
    流体处理装置包括径向通道

    公开(公告)号：US20070128652A1

    公开(公告)日：2007-06-07

    申请号：US11648264

    申请日：2006-12-29

    申请人： Timothy Woudenberg ,  Reid Kowallis

    发明人： Timothy Woudenberg ,  Reid Kowallis

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    摘要： The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    摘要翻译： 在一个方面，本发明提供了一种装置，其包括盘形基底，其限定（1）中央储存区域，（2）多个通道，其与中央储存区域基本上径向流体连通并且基本上径向离开， 所述通道彼此共面，并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，优选（3）至少一个室，并且优选地 三个腔室通过与该通道的远端流体连通的通道连接。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。

    Apparatus and method for confining eluted samples in electrophoresis systems
    9.
    发明授权
    Apparatus and method for confining eluted samples in electrophoresis systems 有权
    将洗脱样品限制在电泳系统中的装置和方法

    公开(公告)号：US07108775B2

    公开(公告)日：2006-09-19

    申请号：US10291088

    申请日：2002-11-08

    申请人： Dar Bahatt ,  Reid Kowallis

    发明人： Dar Bahatt ,  Reid Kowallis

    IPC分类号： G01N27/447

    CPC分类号： G01N27/44717

    摘要： The present teachings provide a microfluidic apparatus comprising a body defining at least one channel that extends through said body, the channel including an inlet and an outlet; and an electrode positioned in proximity to the body and configured to provide an electrical field near the outlet of the channel to at least partially confine an eluted sample component passing from the channel. The present teachings also provide an electrophoresis system, comprising a microfluidic chip defining a plurality of channels passing therethrough, each of the channels having an inlet and an outlet; a first electrode in electrical communication with the inlet of each of the channels; a second electrode in electrical communication with the outlet of each of the channels; and a third electrode in electrical communication with the outlet of each of the channels, wherein the third electrode is positioned to provide an electrical field to at least partially confine an eluted sample component passing from any of the channels. The present teachings also provide a method for confining a sample component eluting from a channel of a microfluidic chip, comprising generating an electrical field in proximity to an outlet of a channel in a microfluidic chip to at least partially confine an eluted sample component passing from the channel, thereby reducing distortion of the eluted sample component and mixing with an adjacent eluted sample component.

    摘要翻译： 本发明提供一种微流体装置，其包括限定穿过所述主体的至少一个通道的主体，所述通道包括入口和出口; 以及电极，其位于所述主体附近并且被配置为在所述通道的出口附近提供电场，以至少部分地限制从所述通道通过的洗脱样品成分。 本教导还提供了一种电泳系统，其包括限定穿过其中的多个通道的微流体芯片，每个通道具有入口和出口; 与每个通道的入口电连通的第一电极; 与每个通道的出口电连通的第二电极; 以及与每个通道的出口电连通的第三电极，其中第三电极被定位成提供电场以至少部分地限制从任何通道通过的洗脱样品成分。 本教导还提供了一种限制从微流体芯片的通道洗脱的样品组分的方法，包括在微流体芯片中的通道的出口附近产生电场，以至少部分地限制从 从而减少洗脱的样品组分的变形并与相邻洗脱的样品组分混合。