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16 条记录 (耗时 0.025 秒)

    Apparatus and method for the precise location of reaction plates
    8.
    发明申请
    Apparatus and method for the precise location of reaction plates 审中-公开
    反应板精确定位的装置和方法

    公开(公告)号：US20050152810A1

    公开(公告)日：2005-07-14

    申请号：US11069322

    申请日：2005-02-28

    申请人： Reid Kowallis ,  David Cox

    发明人： Reid Kowallis ,  David Cox

    IPC分类号： G01N35/02 ,  B01J19/00 ,  B01L3/00 ,  B01L3/02 ,  C40B20/02 ,  C40B60/10 ,  G01N35/10

    CPC分类号： B01L3/5085 ,  G01N35/1065 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/2575

    摘要： Generally, the present invention provides a device and method for accurately locating a multi-well plate at a plate-support location, e.g., a work surface, of an automated laboratory machine, such that one or more acting members of the machine, such as an array of pipette tips, optical sensors, or the like, can accurately address and operate on the individual wells. Interior and/or exterior surface regions of one or more wells of a multi-well plate are used as the primary plate features engaged by locating structure of the machine. In one particular embodiment one or more upwardly tapered projections extend from a plate-support surface of a plate-handling machine for mating engagement with the exterior surface regions of one or more wells. In another embodiment, the exterior surface regions along one or more well bottoms are engagingly received within bores, or other receiving structure, formed on the plate-support surface of a machine. In a further embodiment, one or more downwardly extending projections depend from an acting-member support, along with the acting members of a machine. Introduction of the projections into some of the wells of a multi-well plate serves to align the acting members with the plate's other wells. A biasing assembly can be used to press together the engaging surface regions of the wells and the locating structures of the machine.

    摘要翻译： 通常，本发明提供了一种用于在自动化实验室机器的板支撑位置（例如工作表面）处精确地定位多孔板的装置和方法，使得机器的一个或多个作用构件，例如 移液管尖端，光学传感器等的阵列可以精确地解决和操作各个井。 使用多孔板的一个或多个孔的内部和/或外部表面区域作为通过定位机器的结构而接合的主要板材特征。 在一个特定实施例中，一个或多个向上锥形突起从板处理机的板支撑表面延伸，用于与一个或多个井的外表面区域配合接合。 在另一个实施例中，沿着一个或多个井底的外表面区域接合地容纳在形成在机器的板支撑表面上的孔或其它接收结构内。 在另一个实施例中，一个或多个向下延伸的突起与作用构件支撑件一起，与机器的作用构件一起。 将突出物引入多孔板的一些孔中用于使作用构件与板的其它孔对齐。 偏置组件可用于将井的接合表面区域和机器的定位结构压在一起。

    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices
    9.
    发明申请
    Bubble-free and pressure-generating electrodes for electrophoretic and electroosmotic devices 失效

    公开(公告)号：US20050061669A1

    公开(公告)日：2005-03-24

    申请号：US10984239

    申请日：2004-11-09

    申请人： Timothy Woudenberg ,  Zbigniew Bryning ,  Reid Kowallis

    发明人： Timothy Woudenberg ,  Zbigniew Bryning ,  Reid Kowallis

    IPC分类号： G01N27/30 ,  C02F1/461 ,  C02F1/469 ,  G01N27/403 ,  G01N27/447 ,  G01N27/26 ,  G01N27/27

    CPC分类号： G01N27/44704 ,  C02F1/46109 ,  C02F1/469

    摘要： Bubble-free electrodes, electrochemical cells including bubble-free electrodes, analytical devices, and methods for preparing and using them are provided. The analytical devices each include at least one bubble-free electrode. Analytical devices that include an electrochemical cell and a sample containment device are also provided, wherein the electrochemical cell includes an anodic reservoir, a cathodic reservoir, an electrical connection between the anodic reservoir and the cathodic reservoir, and a first bubble-free electrode disposed within one of the anodic reservoir and the cathodic reservoir. A second electrode is disposed within the other reservoir and a power source is provided having a positive terminal that is normally in electrical contact with the first electrode, and a negative terminal that is normally in electrical contact with the second electrode. The analytical device further includes a power source polarity-inverting device for switching the contacts between the terminals of the power source and the first and second electrodes. The sample containment device includes a sample containment chamber having an opening for introducing a sample into the chamber and being positioned with respect to the electrochemical cell such that an electrical field generated by the electrochemical cell can influence a property of a component of a sample disposed in the sample containment chamber. Pressure-generating cells are also provided.

    Fluid processing device comprising radial channels
    10.
    发明申请
    Fluid processing device comprising radial channels 审中-公开
    流体处理装置包括径向通道

    公开(公告)号：US20070128652A1

    公开(公告)日：2007-06-07

    申请号：US11648264

    申请日：2006-12-29

    申请人： Timothy Woudenberg ,  Reid Kowallis

    发明人： Timothy Woudenberg ,  Reid Kowallis

    IPC分类号： C12Q1/68 ,  C12M1/34

    CPC分类号： B01L3/502753 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0645 ,  B01L2300/0803 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0409 ,  B01L2400/0421 ,  C12Q1/686 ,  G01N27/44721 ,  G01N27/44782 ,  G01N27/44791 ,  G01N35/00069 ,  C12Q2565/629

    摘要： The present invention provides, in one aspect, an apparatus that comprises a disc-shaped substrate defining (1) a central reservoir region, (2) a plurality of channels in fluid communication with, and emanating substantially radially from, the central reservoir region, the channels being coplanar with each other, and each channel having (i) a proximal end which is linked to the reservoir region, and (ii) a distal end, and preferably (3) for each channel, at least one chamber, and preferably three chambers, linked by a passageway in fluid communication with the distal end of that channel. Preferably, each passageway leads from each chamber in a direction that is initially away from the central reservoir region, whereby centrifugation of the substrate about a central axis that is perpendicular to the channels is effective to disperse liquid from the central reservoir region into the channels and chambers, such that any air bubbles in the chambers, channels, and passageways are forced towards the axis of rotation, when such liquid is present in the central reservoir region.

    摘要翻译： 在一个方面，本发明提供了一种装置，其包括盘形基底，其限定（1）中央储存区域，（2）多个通道，其与中央储存区域基本上径向流体连通并且基本上径向离开， 所述通道彼此共面，并且每个通道具有（i）连接到储存器区域的近端，以及（ii）用于每个通道的远端，优选（3）至少一个室，并且优选地 三个腔室通过与该通道的远端流体连通的通道连接。 优选地，每个通道从最初远离中心储存器区域的方向引导每个室，由此衬底围绕垂直于通道的中心轴的离心有效地将液体从中央储存器区域分散到通道中，并且 当这种液体存在于中央储存区域中时，腔室，通道和通道中的任何气泡被迫朝向旋转轴线。