知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.037 秒)

    Methods of detecting one or more bioterrorism target agents
    3.
    发明申请
    Methods of detecting one or more bioterrorism target agents 审中-公开
    检测一种或多种生物恐怖目标试剂的方法

    公开(公告)号：US20100279278A1

    公开(公告)日：2010-11-04

    申请号：US11998615

    申请日：2007-11-30

    申请人： Marc R. Labgold

    发明人： Marc R. Labgold

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6804 ,  C12Q2565/607 ,  C12Q2563/149 ,  C12Q2563/131

    摘要： The present invention provides a methods and compositions for early diagnosis of exposure to or infection by a chemical or biological weapon by rapid and specific detection of one or more bioterrorism target agents in a sample.

    摘要翻译： 本发明提供了用于通过快速和具体检测样品中的一种或多种生物恐怖目标试剂来早期诊断化学或生物武器的暴露或感染的方法和组合物。

    Microscale fluidic devices for electrochemical detection of biological molecules
    4.
    发明申请
    Microscale fluidic devices for electrochemical detection of biological molecules 审中-公开
    用于电化学检测生物分子的微型流体装置

    公开(公告)号：US20080103064A1

    公开(公告)日：2008-05-01

    申请号：US11808785

    申请日：2007-06-13

    申请人： Marc R. Labgold

    发明人： Marc R. Labgold

    IPC分类号： C40B60/10

    CPC分类号： C40B60/04 ,  C40B20/08 ,  C40B30/04

    摘要： The present invention provides microdevices for electrochemical detection of target agents in a fluid sample. The microdevices each comprise an elongated microstructure having an inlet for introduction of a fluid sample potentially containing a target agent, and an outlet to allow the sample to flow through the region of the microdevice that allows detection of the target agent. This detection is mediated through hybridization of nucleic acids corresponding to a target agent with device-associated nucleic acids and subsequent binding of an electrochemical detection agent to allow the transfer of an electron to or from the electrode. In specific embodiment, the device comprises: a hollow elongated microstructure with a conductive surface on the internal surface; b) insulating polymer that is uniformly distributed on the conductive surface; c) adapter molecule associated with the insulating polymer, and d) a plurality of associated nucleic acids conjugated to the polymer surface in a specific orientation.

    摘要翻译： 本发明提供用于液体样品中靶物质的电化学检测的微型装置。 微型装置各自包括细长的微结构，其具有用于引入潜在地含有目标试剂的流体样品的入口和允许样品流过允许检测目标试剂的微型装置的区域的出口。 该检测通过对应于靶物质的核酸与器件相关核酸的杂交以及随后的电化学检测剂的结合以允许将电子转移到电极或从电极转移来介导。 在具体实施例中，该装置包括：在内表面上具有导电表面的中空细长微结构; b）均匀分布在导电表面上的绝缘聚合物; c）与绝缘聚合物相关的衔接子分子，和d）以特定方向与聚合物表面缀合的多个相关核酸。