公开(公告)号：US09962696B2

公开(公告)日：2018-05-08

申请号：US14861930

申请日：2015-09-22

Applicant: Universiteit Leiden

Inventor： Paul Vullo ,  Gerald Urban ,  Susann Podszun

IPC: F15C1/02 ,  B01L3/00

CPC classification number: B01L3/502707 ,  B01L3/502723 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502784 ,  B01L2200/0621 ,  B01L2200/0642 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/089 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/0605 ,  B01L2400/0688 ,  B01L2400/082 ,  B01L2400/086 ,  B01L2400/088 ,  Y10T137/8593

Abstract: The present invention relates to phaseguide patterns for use in fluid systems such as channels, chambers, and flow through cells. In order to effectively control filling and/or emptying of fluidic chambers and channels, techniques for a controlled overflowing of phaseguides are proposed. In addition, techniques of confined liquid patterning in a larger fluidic structure, including approaches for patterning overflow structures and the specific shape of phaseguides, are provided. The invention also proposes techniques to effectively rotate the advancement of a liquid/air meniscus over a certain angle. In particular, a phaseguide pattern for guiding a flow of a liquid contained within a compartment is provided, wherein an overflow of the phaseguide by a moving liquid phase is controlled by a local change in capillary force along the phaseguide, wherein said overflow by the liquid over the phaseguide is provoked at the position of the local change in capillary force.

公开(公告)号：US09956555B2

公开(公告)日：2018-05-01

申请号：US15264257

申请日：2016-09-13

Applicant: RareCyte, Inc.

Inventor： Lance U'Ren ,  Ronald Seubert

IPC: B01D21/26 ,  G01N33/49 ,  B01L3/00 ,  G01N1/40 ,  B01L9/00

CPC classification number: B01L3/50215 ,  B01D21/26 ,  B01D21/262 ,  B01L3/5021 ,  B01L3/5635 ,  B01L9/50 ,  B01L2200/026 ,  B01L2200/0652 ,  B01L2200/0673 ,  B01L2300/0672 ,  B01L2300/0848 ,  B01L2300/0851 ,  B01L2400/0409 ,  B01L2400/0683 ,  G01N1/4077 ,  G01N33/491 ,  G01N2001/4083 ,  Y10T436/25375

Abstract: This disclosure is directed to an apparatus, system and method for retrieving target material from a suspension. A system includes a processing vessel, a displacement fluid, and a tube. The tube includes a funnel, a cannula, and a cavity. The cannula allows for fluid communication between the funnel and the cavity, such that the processing vessel is inserted into the cavity, and the cannula extends into the processing vessel.

公开(公告)号：US20180106704A1

公开(公告)日：2018-04-19

申请号：US15660004

申请日：2017-07-26

Applicant: Lions VisionGift

Inventor： Khoa D. Tran

IPC: G01N1/28 ,  G01N21/03 ,  G01N15/10

CPC classification number: G01N1/28 ,  A61F2/0095 ,  A61F2/142 ,  B01L3/508 ,  B01L2200/185 ,  B01L2300/0609 ,  B01L2300/0832 ,  B01L2300/0851 ,  C12N5/0621 ,  C12N5/0693 ,  C12N5/0697 ,  C12N2529/10 ,  G01N15/10 ,  G01N21/03 ,  G01N21/4795 ,  G01N21/55 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2021/0342

Abstract: Assemblies for storing, handling, transporting, viewing, evaluating, and/or shipping corneal tissue are provided. The assemblies may include a viewing chamber and a corneal tissue carrier removably coupled to an inner portion of the viewing chamber. The assemblies may further include a corneal tissue sample disposed within the corneal tissue carrier. Methods of processing a corneal tissue sample and administering the corneal tissue sample to a subject are also provided.

公开(公告)号：US09945839B2

公开(公告)日：2018-04-17

申请号：US15351293

申请日：2016-11-14

Applicant: RareCyte, Inc.

Inventor： Daniel Campton ,  Joshua Nordberg ,  Steve Quarre ,  David Stewart ,  Ronald Seubert

IPC: G01N33/49 ,  B01L3/00 ,  G01N1/40 ,  B01D21/26 ,  B01L9/00

CPC classification number: G01N33/491 ,  B01D21/262 ,  B01L3/5021 ,  B01L3/50215 ,  B01L3/5635 ,  B01L9/50 ,  B01L2200/026 ,  B01L2300/046 ,  B01L2300/0672 ,  B01L2300/0851 ,  B01L2400/0605 ,  B01L2400/0683 ,  G01N1/4077 ,  G01N2001/4083 ,  Y10T436/25375

Abstract: This disclosure is directed to an apparatus, system and method for retrieving a target material from a suspension. A system includes a displacement fluid, a collector, and a primary vessel. In another implementation, the system includes a processing vessel, a displacement fluid, a collector, and a primary vessel.

公开(公告)号：US09880102B2

公开(公告)日：2018-01-30

申请号：US15671422

申请日：2017-08-08

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： Kurt J. Halverson ,  Raymond J. Kenney ,  Olester Benson, Jr. ,  Raymond P. Johnston ,  Guoping Mao ,  Patrick R. Fleming ,  George Van Dyke Tiers ,  Naiyong Jing

IPC: G01N21/64 ,  G01N21/75 ,  B01L3/00 ,  B29C59/04 ,  G01N21/03 ,  G01N21/25 ,  G01N21/31 ,  G01N21/55 ,  B29C35/08 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C59/02

CPC classification number: G01N21/75 ,  B01L3/50853 ,  B01L2200/0689 ,  B01L2200/12 ,  B01L2300/044 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0851 ,  B01L2300/0887 ,  B29C35/0888 ,  B29C59/046 ,  B29C59/08 ,  B29C59/10 ,  B29C59/14 ,  B29C59/16 ,  B29C2035/0827 ,  B29C2059/023 ,  G01N21/03 ,  G01N21/253 ,  G01N21/31 ,  G01N21/55 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2021/0346 ,  G01N2201/0446 ,  G01N2201/064 ,  G01N2201/08

Abstract: The disclosure provides microstructured articles and methods useful for detecting an analyte in a sample. The articles include microwell arrays. The articles can be used with an optical system component in methods to detect or characterize an analyte.

公开(公告)号：US09878323B2

公开(公告)日：2018-01-30

申请号：US13662553

申请日：2012-10-29

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: C12Q1/00 ,  B01L3/00 ,  G01N33/543

CPC classification number: B01L3/5025 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/105 ,  G01N33/54366 ,  G01N33/54393 ,  Y10S436/809

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：US20180021219A1

公开(公告)日：2018-01-25

申请号：US15653816

申请日：2017-07-19

Applicant: Sysmex Corporation

Inventor： Ayato TAGAWA ,  Junko KOJIMA ,  Nobuyasu HORI ,  Kenji AKAMA ,  Masaya OKADA ,  Kunpeng CAI ,  Samiko HOSOYA ,  Shigeki IWANAGA

IPC: A61J1/14 ,  A61J1/16 ,  A61J1/05

CPC classification number: A61J1/1475 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150748 ,  A61B5/150755 ,  A61B5/150969 ,  A61B5/15105 ,  A61B5/155 ,  A61J1/05 ,  A61J1/165 ,  B01L3/502715 ,  B01L3/5082 ,  B01L2200/0684 ,  B01L2300/024 ,  B01L2300/0672 ,  B01L2300/069 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2300/1822 ,  B01L2300/1894

Abstract: A blood collection device including a flow path to flow blood by capillary action capable of collecting a large amount of blood is provided. The blood collection device includes an introduction inlet 23 for introducing the blood of the subject M, a substrate 20 connected to the introduction inlet 23 and including a flow path 25 to flow the blood by capillary action, and a cooling body 30 for cooling the flow path 25.

公开(公告)号：US09865985B1

公开(公告)日：2018-01-09

申请号：US13923344

申请日：2013-06-20

Applicant: Teradiode, Inc.

Inventor： Bien Chann ,  Robin Huang ,  Parviz Tayebati

IPC: H01S3/10 ,  H01S3/105 ,  B01L3/00 ,  G01N1/31 ,  G01N1/38 ,  H01S5/0625 ,  H01S5/40 ,  H01S5/022 ,  H01S3/101 ,  H01S5/00 ,  H01S3/00 ,  H01S5/14 ,  H01S3/1055 ,  H01S3/063 ,  H01S3/081 ,  H01S3/08

CPC classification number: H01S3/105 ,  B01L3/50851 ,  B01L2200/147 ,  B01L2300/046 ,  B01L2300/0654 ,  B01L2300/0851 ,  G01N1/31 ,  G01N1/38 ,  H01S3/0085 ,  H01S3/0635 ,  H01S3/08009 ,  H01S3/0812 ,  H01S3/10 ,  H01S3/10023 ,  H01S3/101 ,  H01S3/1055 ,  H01S5/0071 ,  H01S5/0085 ,  H01S5/02288 ,  H01S5/02292 ,  H01S5/06253 ,  H01S5/143 ,  H01S5/4012 ,  H01S2301/20

Abstract: A system and method for tuning and infrared source laser in the Mid-IR wavelength range. The system and method comprising, at least, a plurality of individually tunable emitters, each emitter emitting a beam having a unique wavelength, a grating, a mirror positioned after the grating to receive at least one refracted order of light of at least one beam and to redirect the beam back towards the grating, and a micro-electro-mechanical systems device containing a plurality of adjustable micro-mirrors.

公开(公告)号：US09862919B2

公开(公告)日：2018-01-09

申请号：US14931917

申请日：2015-11-04

Applicant: DIAMOND INVENTION UG (HAFTUNGSBESCHRAENKT)

Inventor： Robert Niedl ,  Carsten Beta

IPC: C12M1/34 ,  C12M1/00 ,  C12M1/30 ,  C12Q1/04 ,  B01L9/00 ,  B01L3/00 ,  G01N21/84 ,  C12M1/12 ,  C12Q1/68

CPC classification number: C12M23/20 ,  B01L3/5023 ,  B01L9/52 ,  B01L2200/0621 ,  B01L2300/047 ,  B01L2300/0816 ,  B01L2300/0851 ,  B01L2300/0887 ,  B01L2300/126 ,  B01L2400/0406 ,  C12M23/38 ,  C12M25/02 ,  C12M33/02 ,  C12M37/04 ,  C12Q1/04 ,  C12Q1/689 ,  G01N21/8483

Abstract: The present invention relates to a device for the identification of microorganisms, comprising: a) a carrier 1, wherein an absorbent material 2 is arranged on the carrier 1, b) at least one intermediate sealing layer 3, with at least one cut-out 4, which is designed to receive the microorganisms to be identified, these being present on a micropore filter 5, c) at least one nonwoven reaction fabric comprising an absorbent material 2 on which at least one absorption field 7 and/or at least one liquid-transporting structure 8 is arranged for the taking up of reagents to identify microorganisms, and d) a cover plate 9. Furthermore, a method for the identification of microorganisms is used in conjunction with the device according to the invention.With the present invention, microorganisms in a sample can be identified very quickly—within a few minutes. In this, the test system is isolated from the environment, so avoiding danger to people and the environment from a positive test finding.

公开(公告)号：US09846151B2

公开(公告)日：2017-12-19

申请号：US14359556

申请日：2012-11-20

Applicant: Ovizio Imaging Systems NV/SA

Inventor： Olivier Magniette

IPC: G01N33/487 ,  G01N21/03 ,  G01N33/574 ,  G01N1/40 ,  G03H1/00 ,  B01L3/00 ,  A61B10/02 ,  G03H1/04

CPC classification number: G01N33/48778 ,  A61B10/0291 ,  A61B2010/0216 ,  B01L3/502 ,  B01L3/5082 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2300/023 ,  B01L2300/042 ,  B01L2300/0609 ,  B01L2300/0681 ,  B01L2300/0803 ,  B01L2300/0832 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2400/086 ,  G01N1/405 ,  G01N21/03 ,  G01N33/57411 ,  G03H1/0443 ,  G03H2001/005

Abstract: The current invention concerns a sample vial for receiving a liquid cell sample, to be used in conjunction with a digital holographic microscope (DHM), said sample vial comprises at least two compartments in fluid connection with one another, said compartments comprising at least one pair of screening surfaces, said screening surfaces are essentially flat; and characterized in that the distance between the pair of screening surfaces of the second compartment is smaller than the distance between the pair of screening surfaces of the first compartment. In a second and third aspect, the current invention pertains to a method and system for analyzing a liquid cell sample by DHM, employing the sample vial of the current invention.