ANTAGONISTIC SMALL MOLECULE COMPOUND HAVING TOLL-LIKE RECEPTOR 7/9 INHIBITORY FUNCTION

    公开(公告)号:US20230339935A1

    公开(公告)日:2023-10-26

    申请号:US17923061

    申请日:2021-05-04

    Inventor: Sangdun CHOI

    CPC classification number: C07D471/04

    Abstract: An antagonistic small molecule compound having a Toll-like receptor (TLR) 7/9 inhibitory function, a method for producing the same, and a composition containing the compound are disclosed. The novel small molecule compound has a function of inhibiting a TLR7/9 signaling path. The novel compound not only blocks secretion of TMF-α induced by CpG-ODN (TLR9 agonist) or IMQ (TLR7 agonist) but also inhibits generation of inflammatory cytokines and, thus, is useful for prevention or treatment of TLR7/9-related autoimmune diseases and inflammatory diseases including systemic lupus erythematosus and psoriasis, in particular.

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