-
公开(公告)号：US20230357415A1
公开(公告)日：2023-11-09
申请号：US18024143
申请日：2021-09-10
Inventor： Yong Sung KIM , Hae-Sim PARK , Jung Eun KIM , Keunok JUNG , Dong-Hyun LEE
IPC: C07K16/28
CPC classification number: C07K16/2866 , C07K2317/31 , C07K2317/30 , C07K2317/622 , C07K2317/92 , C07K2317/24 , C07K2317/732 , C07K2317/35 , C07K2317/522 , C07K2317/526
Abstract: An IL-4Rα×IL-5Rα bispecific antibody that simultaneously binds to interleukin (IL)-4 receptor a (IL-4Rα, CD124) and IL-5 receptor a (IL-5Rα, CD125) is provided. A multispecific antibody including the bispecific antibody, a nucleic acid encoding the bispecific antibody or multispecific antibody, a vector including the nucleic acid, and cells transformed by the vector are disclosed. Additionally, a method for producing the bispecific antibody and therapeutic uses of the multispecific antibody in preventing or treating allergic diseases, inflammatory diseases, and eosinophilic diseases associated with IL-4, IL-13 and/or IL-5 are disclosed.
-
公开(公告)号：US20230416380A1
公开(公告)日：2023-12-28
申请号：US18025833
申请日：2021-09-10
Inventor： Yong Sung KIM , Hae-Sim PARK , Jung Eun KIM , Keunok JUNG , Dong-Hyun LEE
CPC classification number: C07K16/2866 , G01N33/6869 , A61P37/08 , G01N2333/7155 , C07K2317/24 , C07K2317/732 , G01N2800/24 , C07K2317/92 , C07K2317/34 , C07K2317/76 , C07K2317/73
Abstract: A humanized antibody or antigen-binding fragment thereof that binds to the human IL-5 receptor alpha subunit (IL-5Rα), which is a receptor of human interleukin-5 (IL-5); a nucleic acid encoding the antibody or antigen-binding fragment thereof; a vector containing the nucleic acid; and a cell transformed with the vector are disclosed. A method for producing the antibody or antigen-binding fragment thereof; a conjugate containing the antibody or antigen-binding fragment thereof; a bispecific or multispecific antibody containing the antibody or antigen-binding fragment thereof; and a composition thereof are disclosed. Also disclosed are methods for preventing or treating an allergic disease, an inflammatory disease and/or a disease caused by an increase in eosinophils; and for diagnosis of allergic diseases, inflammatory diseases, and/or diseases caused by an increase in eosinophils.
-
公开(公告)号：US20210403580A1
公开(公告)日：2021-12-30
申请号：US17292050
申请日：2019-11-07
Inventor： Yong Sung KIM , Hae-Sim PARK , Jung Eun KIM , Keunok JUNG
Abstract: An antibody or antigen-binding fragment thereof, which binds with a high pM-level affinity to a human IL-4 receptor alpha chain that is a human IL-4 receptor, is provided. The antibody or antigen-binding fragment has a different epitope and a different antigen dissociation rate than existing antibodies. A nucleic acid encoding the antibody or antigen-binding fragment thereof, a vector including the nucleic acid, a cell transformed with the vector, a method for producing the antibody or antigen-binding fragment thereof, a conjugate comprising the antibody or antigen-binding fragment thereof, a composition for preventing or treating inflammatory diseases, and a composition for diagnosing inflammatory diseases are disclosed.
-
-
Search Results
3
records
(took 0.014 seconds)
