公开(公告)号：US20230357415A1

公开(公告)日：2023-11-09

申请号：US18024143

申请日：2021-09-10

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yong Sung KIM ,  Hae-Sim PARK ,  Jung Eun KIM ,  Keunok JUNG ,  Dong-Hyun LEE

IPC: C07K16/28

CPC classification number: C07K16/2866 ,  C07K2317/31 ,  C07K2317/30 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/35 ,  C07K2317/522 ,  C07K2317/526

Abstract: An IL-4Rα×IL-5Rα bispecific antibody that simultaneously binds to interleukin (IL)-4 receptor a (IL-4Rα, CD124) and IL-5 receptor a (IL-5Rα, CD125) is provided. A multispecific antibody including the bispecific antibody, a nucleic acid encoding the bispecific antibody or multispecific antibody, a vector including the nucleic acid, and cells transformed by the vector are disclosed. Additionally, a method for producing the bispecific antibody and therapeutic uses of the multispecific antibody in preventing or treating allergic diseases, inflammatory diseases, and eosinophilic diseases associated with IL-4, IL-13 and/or IL-5 are disclosed.

公开(公告)号：US20240302365A1

公开(公告)日：2024-09-12

申请号：US18255680

申请日：2021-11-12

Applicant: MD HEALTHCARE INC. ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Hae-Sim PARK ,  Youngwoo CHOI ,  Yoon-Keun KIM

IPC: G01N33/564 ,  G01N33/68

CPC classification number: G01N33/564 ,  G01N33/6854 ,  G01N2333/212 ,  G01N2800/24

Abstract: Provided is a method for providing information on chronic urticaria and, more specifically, the provided is a method for diagnosing chronic urticaria by measuring an allergen-specific IgE antibody for a vesicle derived from Acinetobacter bacteria; a diagnostic composition using the same; and the like.

公开(公告)号：US20230416380A1

公开(公告)日：2023-12-28

申请号：US18025833

申请日：2021-09-10

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yong Sung KIM ,  Hae-Sim PARK ,  Jung Eun KIM ,  Keunok JUNG ,  Dong-Hyun LEE

IPC: C07K16/28 ,  G01N33/68 ,  A61P37/08

CPC classification number: C07K16/2866 ,  G01N33/6869 ,  A61P37/08 ,  G01N2333/7155 ,  C07K2317/24 ,  C07K2317/732 ,  G01N2800/24 ,  C07K2317/92 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/73

Abstract: A humanized antibody or antigen-binding fragment thereof that binds to the human IL-5 receptor alpha subunit (IL-5Rα), which is a receptor of human interleukin-5 (IL-5); a nucleic acid encoding the antibody or antigen-binding fragment thereof; a vector containing the nucleic acid; and a cell transformed with the vector are disclosed. A method for producing the antibody or antigen-binding fragment thereof; a conjugate containing the antibody or antigen-binding fragment thereof; a bispecific or multispecific antibody containing the antibody or antigen-binding fragment thereof; and a composition thereof are disclosed. Also disclosed are methods for preventing or treating an allergic disease, an inflammatory disease and/or a disease caused by an increase in eosinophils; and for diagnosis of allergic diseases, inflammatory diseases, and/or diseases caused by an increase in eosinophils.

公开(公告)号：US20210403580A1

公开(公告)日：2021-12-30

申请号：US17292050

申请日：2019-11-07

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yong Sung KIM ,  Hae-Sim PARK ,  Jung Eun KIM ,  Keunok JUNG

IPC: C07K16/28 ,  A61K47/68 ,  G01N33/68 ,  A61P29/00

Abstract: An antibody or antigen-binding fragment thereof, which binds with a high pM-level affinity to a human IL-4 receptor alpha chain that is a human IL-4 receptor, is provided. The antibody or antigen-binding fragment has a different epitope and a different antigen dissociation rate than existing antibodies. A nucleic acid encoding the antibody or antigen-binding fragment thereof, a vector including the nucleic acid, a cell transformed with the vector, a method for producing the antibody or antigen-binding fragment thereof, a conjugate comprising the antibody or antigen-binding fragment thereof, a composition for preventing or treating inflammatory diseases, and a composition for diagnosing inflammatory diseases are disclosed.

公开(公告)号：US20210052675A1

公开(公告)日：2021-02-25

申请号：US16968058

申请日：2019-02-01

Applicant: MD HEALTHCARE INC. ,  AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Yoon-Keun KIM ,  Hae-Sim PARK

IPC: A61K35/744 ,  C12Q1/686 ,  A61K9/00

Abstract: Provided are vesicles derived from bacteria of the genus Lactococcus and a use thereof, and the inventors experimentally confirmed that the vesicles were significantly reduced in samples obtained from patients with diabetes, myocardial infarction, atrial fibrillation, stroke, renal failure, Parkinson's disease and depression, compared with a normal individual, and the vesicles inhibited the secretion of inflammation mediators caused by pathogenic vesicles. Therefore, it is expected that the vesicles derived from bacteria of the genus Lactococcus can be effectively used for a method of diagnosing diabetes, myocardial infarction, atrial fibrillation, stroke, renal failure, Parkinson's disease or depression, and a composition for preventing or treating the disease or inflammatory disease.