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公开(公告)号：US20200276255A1
公开(公告)日：2020-09-03
申请号：US16803968
申请日：2020-02-27
Inventor： Seon-Yong JEONG , Eunkuk PARK
IPC: A61K36/185 , A61K36/40 , A61P5/30
Abstract: The present invention provides a pharmaceutical composition and health functional food composition for preventing or treating female menopausal disease including extract of Ribes fasciculatum leaves as an active ingredient, and a pharmaceutical composition and health functional food composition for preventing or treating female menopausal disease including an extract of Cornus officinalis and extract of Ribes fasciculatum leaves as active ingredients.
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2.发明申请公开(公告)号：US20200165674A1
公开(公告)日：2020-05-28
申请号：US16612031
申请日：2018-05-10
Inventor： Seon-Yong JEONG , Eunkuk PARK , Gijeong KIM
IPC: C12Q1/6883 , G01N33/68
Abstract: A COTL1 gene or protein maintains and regulates the homeostasis of hematopoietic stem cells. A method of diagnosis and treatment of blood-related disease caused either by abnormalities in the homeostasis of hematopoietic stem cells, which result from a mutation in the COTL1 gene or a decrease in the expression of the COTL1 protein, or by an imbalance between the differentiation or proliferation and damage or death of hematopoietic stem cells, or by abnormalities in mitochondrial homeostasis. The COTL1 gene or protein plays an important role in regulating mitochondrial morphology, and when it is knocked down, the number of hematopoietic stem cells decreases.
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3.发明公开公开(公告)号：US20230355710A1
公开(公告)日：2023-11-09
申请号：US17777464
申请日：2020-11-19
Inventor： Seon Yong JEONG , Eunkuk PARK
IPC: A61K38/17 , A61P25/28 , C12Q1/6883 , G01N33/68
CPC classification number: A61K38/1709 , A61P25/28 , C12Q1/6883 , G01N33/6896 , C12Q2600/158 , G01N2800/2814
Abstract: The present invention relates to a composition for diagnosing, preventing, or treating cognitive dysfunction comprising, as an active ingredient, COTL1 protein or a gene encoding same. The COTL1 protein or the gene encoding same of the present invention plays a vital role in mitochondrial morphology regulation. In addition, when the expression thereof is inhibited, learning ability and memory are deteriorated, and when the inhibited expression thereof is recovered, cognitive ability is improved, and thus the COTL1 protein or the gene encoding same can be effectively used in the diagnosis and treatment of cognitive dysfunction.
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4.发明申请公开(公告)号：US20220403030A1
公开(公告)日：2022-12-22
申请号：US17777460
申请日：2020-11-19
Inventor： Seon Yong JEONG , Eunkuk PARK , Changgun LEE
Abstract: The present invention relates to a composition, comprising COTL1 as an active ingredient, for diagnosis of a bone disease or obesity. Downregulation of the expression of the COTL1 protein or a gene thereof inhibits the differentiation activity of osteoclasts to reinforce bone density, compared to a normal control, and to increase factors that induce articular inflammation and cartilage degeneration, causing a bone disease such as osteosclerosis or osteoarthritis. Thus, COTL1 protein or a gene coding therefor can be used for diagnosing, preventing, or treating a bone disease such as osteosclerosis or osteoarthritis. In addition, downregulation of the expression of COTL1 protein or a gene coding therefor exhibits an excellent effect of treating obesity by reducing body weight and body fat mass in high-fat diet obesity mouse models and suppressing hepatic fat accumulation and adipocyte sizes and can be used for diagnosing obesity. An inhibitor against the protein or a gene thereof can be used to effectively prevent, alleviate, or treat obesity.
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