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1.发明公开公开(公告)号：US20230355710A1
公开(公告)日：2023-11-09
申请号：US17777464
申请日：2020-11-19
Inventor： Seon Yong JEONG , Eunkuk PARK
IPC: A61K38/17 , A61P25/28 , C12Q1/6883 , G01N33/68
CPC classification number: A61K38/1709 , A61P25/28 , C12Q1/6883 , G01N33/6896 , C12Q2600/158 , G01N2800/2814
Abstract: The present invention relates to a composition for diagnosing, preventing, or treating cognitive dysfunction comprising, as an active ingredient, COTL1 protein or a gene encoding same. The COTL1 protein or the gene encoding same of the present invention plays a vital role in mitochondrial morphology regulation. In addition, when the expression thereof is inhibited, learning ability and memory are deteriorated, and when the inhibited expression thereof is recovered, cognitive ability is improved, and thus the COTL1 protein or the gene encoding same can be effectively used in the diagnosis and treatment of cognitive dysfunction.
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2.发明申请公开(公告)号：US20220403030A1
公开(公告)日：2022-12-22
申请号：US17777460
申请日：2020-11-19
Inventor： Seon Yong JEONG , Eunkuk PARK , Changgun LEE
Abstract: The present invention relates to a composition, comprising COTL1 as an active ingredient, for diagnosis of a bone disease or obesity. Downregulation of the expression of the COTL1 protein or a gene thereof inhibits the differentiation activity of osteoclasts to reinforce bone density, compared to a normal control, and to increase factors that induce articular inflammation and cartilage degeneration, causing a bone disease such as osteosclerosis or osteoarthritis. Thus, COTL1 protein or a gene coding therefor can be used for diagnosing, preventing, or treating a bone disease such as osteosclerosis or osteoarthritis. In addition, downregulation of the expression of COTL1 protein or a gene coding therefor exhibits an excellent effect of treating obesity by reducing body weight and body fat mass in high-fat diet obesity mouse models and suppressing hepatic fat accumulation and adipocyte sizes and can be used for diagnosing obesity. An inhibitor against the protein or a gene thereof can be used to effectively prevent, alleviate, or treat obesity.
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公开(公告)号：US20210395826A1
公开(公告)日：2021-12-23
申请号：US17395769
申请日：2021-08-06
Inventor： Jin Soon HWANG , Seon Yong JEONG , Hae Sang LEE , Eun Young KIM
IPC: C12Q1/6883
Abstract: The present invention relates to a single nucleotide polymorphism marker for precocious puberty diagnosis or treatment prognosis prediction for the disease, and a use thereof. In the present invention, the DNA of 700 girl patients of precocious puberty is processed on a microarray chip containing a total of 8,754,887 SNP probes so that SNP genotype data is obtained, and 23 SNPs related to the risk of developing precocious puberty are discovered by means of genome-wide association analysis so that the SNPs can be used for precocious puberty diagnosis or treatment prognosis prediction, early diagnosis of precocious puberty can be conveniently and rapidly carried out, and the prediction of treatment effects and prognosis can be carried, and thus the present invention can be effectively used in a personalized treatment.
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