公开(公告)号：US20230322860A1

公开(公告)日：2023-10-12

申请号：US18022394

申请日：2021-08-20

Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Myung-Hee KWON ,  Minjae KIM ,  Jeonghyun LEE ,  Juho CHOI ,  Youngsil SEO

IPC: C07K14/00 ,  A61P37/08 ,  G01N33/68

CPC classification number: C07K14/001 ,  A61K38/00 ,  G01N33/6857 ,  A61P37/08

Abstract: An antibody fragment includes only constant regions of an antibody having no variable regions of an antibody is disclosed. The antibody fragment (IgCw-γ1ε2-4/κ) contains heavy chain and light-chain constant regions in which a gamma constant region ((Cγ1) and an epsilon constant region (Cε2-4) are fused; a nucleic acid encoding the antibody fragment; a kit including the antibody or nucleic acid; and use thereof. The recombinant protein IgCw-γ1ε2-4/κ containing only of the constant regions of an antibody can be used as an Fc epsilon receptor inhibitor for inhibiting allergic responses. Therefore, IgCw-γ1ε2-4/κ can be used in various ways in the biomedical science field.