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124 条记录 (耗时 0.032 秒)

    Process for the preparation of biphenyl derivatives
    26.
    发明授权
    Process for the preparation of biphenyl derivatives 失效
    联苯衍生物的制备方法

    公开(公告)号：US5618975A

    公开(公告)日：1997-04-08

    申请号：US449396

    申请日：1995-05-24

    申请人： Adalbert Wagner ,  Neerja Bhatnagar ,  Jean Buendia ,  Christine Griffoul

    发明人： Adalbert Wagner ,  Neerja Bhatnagar ,  Jean Buendia ,  Christine Griffoul

    IPC分类号： B01J23/44 ,  A61K31/235 ,  A61K31/41 ,  C07B37/04 ,  C07B61/00 ,  C07C41/48 ,  C07C45/61 ,  C07C45/71 ,  C07C47/546 ,  C07C67/30 ,  C07C67/343 ,  C07C69/76 ,  C07C69/767 ,  C07C253/30 ,  C07C255/37 ,  C07C255/40 ,  C07C255/56 ,  C07C303/40 ,  C07C311/09 ,  C07C311/48 ,  C07C311/51 ,  C07C311/52 ,  C07C311/53 ,  C07C311/54 ,  C07C311/57 ,  C07C311/58 ,  C07D257/04 ,  C07C311/21

    CPC分类号： C07D257/04 ,  C07B37/04 ,  C07C253/30 ,  C07C303/40 ,  C07C311/09 ,  C07C311/51 ,  C07C311/58 ,  C07C67/343

    摘要： Biphenyl derivatives and processes for the preparation of biphenyl derivatives are described. A compound of formula (I) is disclosed ##STR1## in which the substituent X is --CHO or --CH(OR.sup.1)OR.sup.2, where R.sup.1 and R.sup.2 independently of one another are (C.sub.1 -C.sub.6)-alkyl or R.sup.1 and R.sup.2 together are an alkylene group (--CH.sub.2).sub.n --, where n is 2, 3 4 or 5 and R is --F, --Cl, --NO.sub.2, --(CH.sub.2).sub.m --COOR.sup.3, --(CH.sub.2).sub.m --CONHR.sup.3, --(CH.sub.2).sub.m --CN, --SO.sub.2 NH--COOR.sup.3, --SO.sub.2 NH--CO--NHR.sup.3, --SO.sub.2 NH--SO.sub.2 --R.sup.3, --NHSO.sub.2 R.sup.3, ##STR2## --PO.sub.3 R.sup.3, --NH--SO.sub.2 --CF.sub.3, --SO.sub.2 NR.sup.4 where R.sup.3 is hydrogen, (C.sub.1 -C.sub.6)-alkyl, (C.sub.3 -C.sub.6)cycloalkyl, or (C.sub.1 -C.sub.6)-alkyl-(C.sub.3 -C.sub.6)cycloalkyl and R.sup.4 is a group .dbd.C--N(CH.sub.3).sub.2, and m is 0, 1, 2, 3, or 4. The invention also relates to a process for the preparation of a compound of the formula (I) in which X is an optionally protected formyl group and R is a group which is itself inert to the reaction conditions of the synthesis, which comprises reacting a compound of the formula (II) ##STR3## with a substituted phenyl-halogen compound of the formula (III) ##STR4## wherein the substituent Hal is a halogen group.

    摘要翻译： 描述了联苯衍生物和制备联苯衍生物的方法。 公开了式（I）化合物，其中取代基X为-CHO或-CH（OR 1）OR 2，其中R 1和R 2彼此独立地为（C 1 -C 6） - 烷基或R 1和 R2一起是亚烷基（-CH 2）n - ，其中n是2,3,4或5，R是-F，-Cl，-NO 2， - （CH 2）m -COOR 3， - （CH 2）m -CONHR 3， - （CH2）m-CN，-SO2NH-COOR3，-SO2NH-CO-NHR3，-SO2NH-SO2-R3，-NHSO2R3，-PO3R3，-NH-SO2-CF3，-SO2NR4，其中R3是氢， （C 1 -C 6） - 烷基，（C 3 -C 6）环烷基或（C 1 -C 6） - 烷基 - （C 3 -C 6）环烷基，R 4是基团= CN（CH 3）2，m是0,1,2 ，3或4.本发明还涉及一种制备式（I）化合物的方法，其中X是任选保护的甲酰基，R是本身对于合成的反应条件是惰性的基团 其包括使式（II）化合物（II）与式（III）取代的苯基 - 卤素化合物（III）反应，其中取代基Hal为卤素基团。

    Process for producing 4-formyl-4'-methylbiphenyl from biphenyl
    27.
    发明授权
    Process for producing 4-formyl-4'-methylbiphenyl from biphenyl 失效
    从联苯生产4-甲酰基-4'-甲基联苯的方法

    公开(公告)号：US5436374A

    公开(公告)日：1995-07-25

    申请号：US281126

    申请日：1994-07-28

    申请人： Makoto Komatsu ,  Susumu Fujiyama ,  Koichi Kida ,  Mitsuharu Kitamura

    发明人： Makoto Komatsu ,  Susumu Fujiyama ,  Koichi Kida ,  Mitsuharu Kitamura

    IPC分类号： B01J27/12 ,  C07B61/00 ,  C07C45/49 ,  C07C47/546

    CPC分类号： C07C45/49

    摘要： A process for producing a 4-formyl-4'-methylbiphenyl from a biphenyl which comprises conducting the carbonylation of the biphenyl with carbon monoxide in the presence of a HF-BF.sub.3 catalyst in a carbonylation reactor to obtain the resulting reaction product solution containing a 4-formylbiphenyl, separating the 4-formylbiphenyl from the reaction product solution, hydrogenating the separated 4-formylbiphenyl to obtain a 4-methylbiphenyl, recycling the 4-methylbiphenyl to the carbonylation reactor, and then conducting both the carbonylation of the biphenyl with carbon monoxide to obtain a formylbiphenyl and the carbonylation of the 4-methylbiphenyl with carbon monoxide to obtain a 4-formyl-4'-methylbiphenyl simultaneously in the presence of the HF-BF.sub.3 catalyst in the carbonylation reactor.

    摘要翻译： 一种由联苯生产4-甲酰基-4'-甲基联苯的方法，其包括在羰基化反应器中，在HF-BF 3催化剂存在下，用一氧化碳进行联苯的羰基化，得到所得到的含有4 - 甲酰基联苯，从反应产物溶液中分离4-甲酰基联苯，氢化分离的4-甲酰基联苯，得到4-甲基联苯，将4-甲基联苯循环到羰基化反应器中，然后进行联苯与一氧化碳的羰基化反应 在羰基化反应器中，在HF-BF 3催化剂的存在下，用一氧化碳得到甲酰基联苯和4-甲基联苯羰基化，得到4-甲酰基-4'-甲基联苯。

    Aromatic compounds, a process for preparation thereof and use of same as perfuming ingredients
    28.
    发明授权
    Aromatic compounds, a process for preparation thereof and use of same as perfuming ingredients 失效

    公开(公告)号：US5324875A

    公开(公告)日：1994-06-28

    申请号：US911447

    申请日：1992-07-10

    申请人： Charles Fehr ,  Jose Galindo

    发明人： Charles Fehr ,  Jose Galindo

    IPC分类号： A61K8/33 ,  A61K8/35 ,  A61Q13/00 ,  C07C13/48 ,  C07C45/00 ,  C07C45/28 ,  C07C45/29 ,  C07C45/30 ,  C07C45/46 ,  C07C45/51 ,  C07C45/61 ,  C07C45/67 ,  C07C45/69 ,  C07C47/546 ,  C07C49/792 ,  C11B9/00 ,  C11D3/50 ,  C11D9/44 ,  D06M23/00 ,  D06M23/02 ,  C07C13/38 ,  C07C13/547

    CPC分类号： C11B9/0053 ,  C07C13/48 ,  C07C45/004 ,  C07C45/28 ,  C07C45/305 ,  C07C45/513 ,  C07C45/673 ,  C07C45/676 ,  C07C45/69 ,  C07C47/546 ,  C07C49/792 ,  C07C2102/10 ,  C07C2103/16

    摘要： Compound of formula ##STR1## wherein a) indexes m and n are identical and stand each for an integer number equal to zero, symbols R.sup.1 and R.sup.2 are identical and represent each a hydrogen atom, or are different and represent each a hydrogen atom or a methyl radical, symbols R.sup.5 and R.sup.8 stand each for a methyl radical, symbols R.sup.6 and R.sup.7 can be identical or different and designate each a hydrogen atom or a methyl radical and, either symbol R.sup.4 represents a methyl radical and symbol R.sup.3 stands for a hydrogen atom or a methyl radical, or symbols R.sup.3 and R.sup.4 represent each a methylene radical belonging to a ring such as indicated by the dotted line, with the proviso that the following combinations are excluded:1. R.sup.1 =R.sup.2 =R.sup.3 =R.sup.6 =R.sup.7 =H, or2. R.sup.1 =R.sup.2 =R.sup.3 =H and R.sup.6 or R.sup.7 =CH.sub.3, or3. R.sup.2 =CH.sub.3 and R.sup.3 =R.sup.6 =R.sup.7 =H, or4. R.sup.2 =CH.sub.3 and R.sup.3 =H and R.sup.6 or R.sup.7 =CH.sub.3, or5. R.sup.1 =R.sup.3 =CH.sub.3, or6. R.sup.3 =R.sup.4 =CH.sub.2 and R.sup.2 or R.sup.7 =CH.sub.3 ; or whereinb) indexes m and n are different and define each an integer number equal to 0 or 1, symbol R.sup.2 stands for a hydrogen atom or a methyl radical, symbols R.sup.1 and R.sup.3 designate each a hydrogen atom, symbol R.sup.4 represents a methyl radical and, either symbols R.sup.5 and R.sup.6 are identical (n=1) and represent each a methylene radical belonging to a ring such as indicated by the dotted line, R.sup.7 representing a hydrogen atom and R.sup.8 a methyl radical, or symbol R.sup.5 stands for a methyl radical and symbol R.sup.6 for a hydrogen atom, R.sup.7 and R.sup.8 being then identical (m=1) and designating each a methylene radical belonging to a ring such as indicated by the dotted line;or any mixture of two or more structural isomers of formula (I).Compounds (I) develop odor notes of the musky type and can therefore be used as active ingredients in perfuming compositions and perfumed articles of varied nature.A process for the preparation of compounds (I) is described.

    Aromatic compounds, a process for preparation thereof and use of same as perfuming ingredients
    30.
    发明授权
    Aromatic compounds, a process for preparation thereof and use of same as perfuming ingredients 失效

    公开(公告)号：US5185318A

    公开(公告)日：1993-02-09

    申请号：US817223

    申请日：1992-01-06

    申请人： Charles Fehr ,  Jose Galindo

    发明人： Charles Fehr ,  Jose Galindo

    IPC分类号： C07C13/48 ,  C07C45/00 ,  C07C45/28 ,  C07C45/30 ,  C07C45/51 ,  C07C45/67 ,  C07C45/69 ,  C07C47/546 ,  C07C49/792 ,  C11B9/00

    CPC分类号： C11B9/0053 ,  C07C13/48 ,  C07C45/004 ,  C07C45/28 ,  C07C45/305 ,  C07C45/513 ,  C07C45/673 ,  C07C45/676 ,  C07C45/69 ,  C07C47/546 ,  C07C49/792 ,  C07C2102/10 ,  C07C2103/16

    摘要： Compound of formula ##STR1## wherein a) indexes m and n are identical and stand each for an integer number equal to zero, symbols R.sup.1 and R.sup.2 are identical and represent each a hydrogen atom, or are different and represent each a hydrogen atom or a methyl radical, symbols R.sup.5 and R.sup.8 stand each for a methyl radical, symbols R.sup.6 and R.sup.7 can be identical or different and designate each a hydrogen atom or a methyl radical and, either symbol R.sup.4 represents a methyl radical and symbol R.sup.3 stands for a hydrogen atom or a methyl radical, or symbols R.sup.3 and R.sup.4 represent each a methylene radical belonging to a ring such as indicated by the dotted line, with the proviso that the following combinations are excluded:1. R.sup.1 =R.sup.2 =R.sup.3 =R.sup.6 =R.sup.7 =H, or2. R.sup.1 =R.sup.2 =R.sup.3 =H and R.sup.6 or R.sup.7 =CH.sub.3, or3. R.sup.2 =CH.sub.3 and R.sup.3 =R.sup.6 =R.sup.7 =H, or4. R.sup.2 =CH.sub.3 and R.sup.3 =H and R.sup.6 or R.sup.7 =CH.sub.3, or5. R.sup.1 =R.sup.3 =CH.sub.3, or6. R.sup.3 =R.sup.4 =CH.sub.2 and R.sup.2 or R.sup.7 =CH.sub.3 ;or whereinb) indexes m and n are different and define each an integer number equal to 0 or 1, symbol R.sup.2 stands for a hydrogen atom or a methyl radical, symbols R.sup.1 and R.sup.3 designates each a hydrogen atom, symbol R.sup.4 represents a methyl radical and, either symbols R.sup.5 and R.sup.6 are identical (n=1) and represent each a methylene radical belonging to a ring such as indicated by the dotted line, R.sup.7 representing a hydrogen atom and R.sup.8 a methyl radical, or symbol R.sup.5 stands for a methyl radical and symbol R.sup.6 for a hydrogen atom, R.sup.7 and R.sup.8 being then identical (m=1) and designating each a methylene radical belonging to a ring such as indicated by the dotted line;or any mixture of two or more structural isomers of formula (I).Compounds (I) develop odor notes or the musky type and can therefore be used as active ingredients in perfruming compositions and perfumed articles of varied nature.A process for the preparation of compound (I) is described.