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    Nondenaturing zwitterionic detergents
    23.
    发明授权
    Nondenaturing zwitterionic detergents 失效
    非变性两性离子洗涤剂

    公开(公告)号：US4372888A

    公开(公告)日：1983-02-08

    申请号：US294203

    申请日：1981-08-19

    Applicant: Leonard M. Hjelmeland

    Inventor： Leonard M. Hjelmeland

    IPC: C11D1/92 ,  C07J1/00 ,  C07J41/00 ,  C07J9/00

    CPC classification number: C11D1/92 ,  C07J41/0061 ,  C07C2103/26

    Abstract: A nondenaturing zwitterionic detergent for proteins which, for example, consists of an effective amount of 3-[(3-chloamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). This detergent is of extreme interest in the biological study of proteins due to its nondenaturing characteristic. Other examples of the group may be prepared from different alicyclic compounds, for example, utilizing cholic acid and in others deoxycholic acid and dehydroabietic acid. A process for the preparation of these compounds starts with cholic or the equivalent and from this is prepared the triethylammonium salt in tetrahydrofuran (THF). After the salt is completely dissolved in THF, ethyl chloroformate is added and the flask cooled to 0.degree. C. Then the mixed anhydride which forms is reacted with dimethylaminopropylamine to form the dimethylaminopropyl derivative of a carboxylic acid amide. Finally, the tertiary amine group is reacted with propanesultone to give the sulfobetaine product.An improved procedure for preparation of these compounds and especially for the last step (as for CHAPSO) to react the N-(3-dimethylaminopropyl)cholamide with sodium-1-chloro-2-hydroxy-3-propanesulfonate.

    Abstract translation: 用于蛋白质的非变性两性离子洗涤剂，其例如由有效量的3 - [（3-氯氨基丙基）二甲基铵]丙烷磺酸盐（CHAPS）组成。 这种洗涤剂由于其非变性特征对蛋白质的生物学研究是非常有兴趣的。 该组的其它实例可以由不同的脂环族化合物制备，例如利用胆酸，其他的脱氧胆酸和脱氢松香酸。 制备这些化合物的方法以胆碱或等价物开始，由此制备四氢呋喃（THF）中的三乙基铵盐。 盐完全溶于THF后，加入氯甲酸乙酯，将烧瓶冷却至0℃。然后将形成的混合酸与二甲基氨基丙胺反应，形成羧酸酰胺的二甲基氨基丙基衍生物。 最后，叔胺基团与丙磺酸内酯反应得到磺基甜菜碱产物。 制备这些化合物，特别是最后一步（对于CHAPSO）使N-（3-二甲基氨基丙基）胆酰胺与1-氯-2-羟基-3-丙磺酸钠反应的改进方法。

    1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor
    24.
    发明授权
    1,9-Dihydroxyoctahydrophenanthrenes and intermediates therefor 失效
    1,9-二羟基八氢菲和其中间体

    公开(公告)号：US4270005A

    公开(公告)日：1981-05-26

    申请号：US78474

    申请日：1979-09-24

    Applicant: Thomas H. Althuis ,  Charles A. Harbert ,  Michael R. Johnson ,  Lawrence S. Melvin, Jr.

    Inventor： Thomas H. Althuis ,  Charles A. Harbert ,  Michael R. Johnson ,  Lawrence S. Melvin, Jr.

    IPC: C07C41/22 ,  C07C41/26 ,  C07C43/225 ,  C07C43/23 ,  C07C45/45 ,  C07C45/46 ,  C07C45/54 ,  C07C45/61 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/73 ,  C07C49/747 ,  C07C49/755 ,  C07C49/83 ,  C07D211/32 ,  C07D213/30 ,  C07D213/50 ,  C07D317/22 ,  C07D317/72 ,  A01N35/00 ,  C07C49/733

    CPC classification number: C07D213/30 ,  C07C41/01 ,  C07C41/22 ,  C07C41/26 ,  C07C45/45 ,  C07C45/46 ,  C07C45/54 ,  C07C45/61 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/73 ,  C07C49/747 ,  C07C49/755 ,  C07C49/83 ,  C07D211/32 ,  C07D213/50 ,  C07D317/22 ,  C07D317/72 ,  C07C2101/14 ,  C07C2103/26

    Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, benzyl, benzoyl, alkanoyl of 1 to 5 carbon atoms or --CO--(CH.sub.2).sub.p --NR'R" wherein p is 0 or an integer from 1 to 4; each of R' and R" when taken individually is hydrogen or alkyl of 1 to 4 carbon atoms; R' and R" when taken together with the nitrogen to which they are attached form a 5- or 6-membered heterocyclic ring selected from piperidino, pyrollo, pyrrolidino, morpholino and N-alkylpiperazino having from 1 to 4 carbon atoms in the alkyl group;R.sub.2 is selected from hydrogen, alkanoyl of 1 to 6 carbon atoms and benzoyl;R.sub.3 is selected from hydrogen, methyl and ethyl;R.sub.4 is selected from hydrogen, alkyl of 1 to 6 carbon atoms and benzyl;Z is selected from:(a) alkylene having from one to nine carbon atoms;(b) --(alk.sub.1).sub.m --X--(alk.sub.2).sub.n -- wherein each of (alk.sub.1) and (alk.sub.2) is alkylene having from 1 to 9 carbon atoms, with the proviso that the summation of carbon atoms in (alk.sub.1) plus (alk.sub.2) is not greater than 9;m and n are each 0 or 1;X is selected from O, S, SO and SO.sub.2 ; andW is selected from hydrogen, methyl, pyridyl, piperidyl, phenyl, monochlorophenyl, monofluorophenyl and ##STR2## wherein W.sub.1 is selected from hydrogen, phenyl, monochlorophenyl and monofluorophenyl; a is an integer from 1 to 5 and b is 0 or an integer from 1 to 4, with the proviso that the sum of a and b is not greater than 5.Compounds I and II are useful as analgesics. Compound III is useful as an intermediate for the preparation of Compounds I and II. Intermediates for the preparation of I, II and III are disclosed. A process for the use of compounds I and II to produce analgesia is also described.

    Abstract translation: 式Ⅰ化合物其中R1是氢，苄基，苯甲酰基，1-5个碳原子的烷酰基或-CO-（CH2）p-NR'R“，其中p 为0或1〜4的整数; 当单独使用时，R'和R“各自为氢或1至4个碳原子的烷基; 当与它们所连接的氮一起取代时，R'和R“与烷基中具有1至4个碳原子的5-或6-元杂环选自哌啶子基，吡咯烷基，吡咯烷子基，吗啉代和N-烷基哌嗪基 组; R 2选自氢，1至6个碳原子的烷酰基和苯甲酰基; R3选自氢，甲基和乙基; R4选自氢，1至6个碳原子的烷基和苄基; Z选自：（a）具有1至9个碳原子的亚烷基; （b） - （alk1）mX-（alk2）n-其中（alk1）和（alk2）各自为具有1至9个碳原子的亚烷基，条件是（alk1）加（alk2） ）不大于9; m和n分别为0或1; X选自O，S，SO和SO2; W选自氢，甲基，吡啶基，哌啶基，苯基，一氯苯基，一氟苯基和其中W1选自氢，苯基，一氯苯基和单氟苯基; a为1至5的整数，b为0或1至4的整数，条件是a和b之和不大于5.化合物I和II可用作止痛剂。 化合物III可用作制备化合物I和II的中间体。 公开了制备I，II和III的中间体。 还描述了使用化合物I和II产生止痛的方法。

    Imaging and recording of information utilizing a tellurium tetrahalide complex of an aromatic amine
    25.
    发明授权
    Imaging and recording of information utilizing a tellurium tetrahalide complex of an aromatic amine 失效
    使用芳族胺的四卤化碲配合物成像和记录信息

    公开(公告)号：US4106939A

    公开(公告)日：1978-08-15

    申请号：US838574

    申请日：1977-10-03

    Applicant: Yew C. Chang ,  Stanford R. Ovshinsky ,  David A. Strand

    Inventor： Yew C. Chang ,  Stanford R. Ovshinsky ,  David A. Strand

    IPC: C07D307/33 ,  C07D307/80 ,  C07D311/16 ,  C07D333/22 ,  C07D333/56 ,  C07D345/00 ,  G03C1/73 ,  G03C5/24 ,  G03C1/00

    CPC classification number: C07D307/33 ,  C07D307/80 ,  C07D311/16 ,  C07D333/22 ,  C07D333/56 ,  C07D345/00 ,  G03C1/734 ,  C07C2103/26 ,  Y10S428/913 ,  Y10T428/31504

    Abstract: Selected areas of a layer comprising an imaging material in the form of a tellurium tetrahalide adduct of an aromatic amine, exemplified by a tellurium tetrachloride adduct of dimethyl aniline, which adduct is free from any diazo groups, in the presence of a spectral photosensitizer, are subjected to the imaging effect of imaging energy, and of development, advantageously of developing energy, causing a change in the tellurium-organic imaging material in the imaged areas accompanied by a change in the detectable characteristic of the imaging material in the imaged areas. The aforesaid imaging material is especially advantageously extended in a matrix of a polymeric or resinous film-forming material. The invention in its generally most advantageous form involves an imaging step employing imaging energy and producing a latent image, followed by a heat development step to produce the detectable recorded information or image.

    Abstract translation: 包含芳族胺的四卤化碲形式的成像材料的成像材料的一部分区域，例如在光谱光敏剂存在下，加合物不含任何重氮基团的二甲基苯胺的四氯化碲加合物。 经受有利于显影能量的成像能量和显影的成像效应，引起成像区域中的碲 - 有机成像材料的变化，伴随着成像区域中成像材料的可检测特性的变化。 上述成像材料特别有利地在聚合物或树脂成膜材料的基质中延伸。 本发明通常最有利的形式涉及使用成像能量并产生潜像的成像步骤，随后是热显影步骤以产生可检测的记录信息或图像。

    Polyhydro-2-phenanthrylideneacetic acids and esters thereof
    27.
    发明授权
    Polyhydro-2-phenanthrylideneacetic acids and esters thereof 失效
    聚氢-2-菲亚
    基乙酸及其酯

    公开(公告)号：US3932482A

    公开(公告)日：1976-01-13

    申请号：US104158

    申请日：1971-01-05

    Applicant: Philip E. Shaw ,  Sol J. Daum ,  Robert L. Clarke

    Inventor： Philip E. Shaw ,  Sol J. Daum ,  Robert L. Clarke

    IPC: C07C59/86 ,  C07C61/38

    CPC classification number: C07C59/86 ,  C07C2103/26

    Abstract: Alkyl polyhydro-2-phenanthrylideneacetates are prepared by interacting the corresponding 2-oxopolyhydrophenanthrenes with a tri-lower-alkyl .alpha.-phosphono-lower-alkanoate. Said alkyl polyhydro-2-phenanthrylideneacetates are hydrolyzed to the free acid, and then reesterified via the acid chloride with a tertiary-amino-lower-alkanol to give basic esters having cardiotonic activity.

    Abstract translation: 烷基多​​羟基-2-菲基亚丙基乙酸酯是通过将相应的2-氧代多羟基苯醚与α-低级烷基α-膦酰基低级链烷酸酯相互作用来制备的。 所述烷基多氢-2-菲基亚丙基乙酸酯水解成游离酸，然后通过酰氯与叔氨基 - 低级链烷醇进行再酯化，得到具有强心活性的碱性酯。

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