公开(公告)号：US3932482A

公开(公告)日：1976-01-13

申请号：US104158

申请日：1971-01-05

Applicant: Philip E. Shaw ,  Sol J. Daum ,  Robert L. Clarke

Inventor： Philip E. Shaw ,  Sol J. Daum ,  Robert L. Clarke

IPC: C07C59/86 ,  C07C61/38

CPC classification number: C07C59/86 ,  C07C2103/26

Abstract: Alkyl polyhydro-2-phenanthrylideneacetates are prepared by interacting the corresponding 2-oxopolyhydrophenanthrenes with a tri-lower-alkyl .alpha.-phosphono-lower-alkanoate. Said alkyl polyhydro-2-phenanthrylideneacetates are hydrolyzed to the free acid, and then reesterified via the acid chloride with a tertiary-amino-lower-alkanol to give basic esters having cardiotonic activity.

Abstract translation: 烷基多​​羟基-2-菲基亚丙基乙酸酯是通过将相应的2-氧代多羟基苯醚与α-低级烷基α-膦酰基低级链烷酸酯相互作用来制备的。 所述烷基多氢-2-菲基亚丙基乙酸酯水解成游离酸，然后通过酰氯与叔氨基 - 低级链烷醇进行再酯化，得到具有强心活性的碱性酯。

公开(公告)号：US3992437A

公开(公告)日：1976-11-16

申请号：US565957

申请日：1975-04-07

Applicant: Philip E. Shaw ,  Sol J. Daum ,  Robert L. Clarke

Inventor： Philip E. Shaw ,  Sol J. Daum ,  Robert L. Clarke

IPC: C07C59/40 ,  C07C59/46 ,  C07C59/56 ,  C07C59/72 ,  C07C59/82 ,  C07C59/90 ,  C07C69/12 ,  C07C49/54

CPC classification number: C07C59/90 ,  C07C59/40 ,  C07C59/46 ,  C07C59/56 ,  C07C59/72 ,  C07C59/82 ,  C07C2103/26

Abstract: Alkyl polyhydro-2-phenanthrylideneacetates are prepared by interacting the corresponding 2-oxopolyhydrophenanthrenes with a tri-lower-alkyl .alpha.-phosphono-lower-alkanoate. Said alkyl polyhydro-2-phenanthrylideneacetates are hydrolyzed to the free acid, and then reesterified via the acid chloride with a tertiaryamino-lower-alkanol to give basic esters having cardiotonic activity.

Abstract translation: 烷基多​​羟基-2-菲基亚丙基乙酸酯是通过将相应的2-氧代多羟基苯醚与α-低级烷基α-膦酰基低级链烷酸酯相互作用来制备的。 将所述烷基多氢-2-菲基亚丙基乙酸酯水解成游离酸，然后用叔氨基 - 低级链烷醇通过酰氯再酯化，得到具有强心活性的碱性酯。