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42 条记录 (耗时 0.019 秒)

    Microbicides
    12.
    发明授权
    Microbicides 失效
    杀菌剂

    公开(公告)号：US5728875A

    公开(公告)日：1998-03-17

    申请号：US703300

    申请日：1996-08-26

    申请人： Martin Zeller

    发明人： Martin Zeller

    IPC分类号： C07D275/02 ,  A01N41/06 ,  C07C303/36 ,  C07C307/06 ,  C07C311/06 ,  C07C311/07 ,  C07C311/11 ,  C07C311/14 ,  C07C311/20 ,  C07C313/06 ,  C07C313/20 ,  C07C317/04 ,  C07C323/60 ,  C07C323/65 ,  C07D295/26 ,  C07C233/76 ,  A61K31/18 ,  C07C303/40 ,  C07C303/35

    CPC分类号： C07D295/26 ,  C07C307/06 ,  C07C311/06 ,  C07C311/07 ,  C07C311/11 ,  C07C311/14 ,  C07C313/06 ,  C07C313/20 ,  C07C317/04 ,  C07C323/60 ,  C07C2101/08 ,  C07C2101/14

    摘要： .alpha.-Amino acid amides of the formula I ##STR1## in which n is the number zero or one; R.sub.1 is C.sub.1 -C.sub.12 alkyl, which is unsubstituted or can be substituted by C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 alkylsulfonyl, C.sub.3 -C.sub.8 cycloalkyl, cyano, C.sub.1 -C.sub.6 alkoxycarbonyl, C.sub.3 -C.sub.6 alkenyloxycarbonyl or C.sub.3 -C.sub.6 alkynyloxycarbonyl; C.sub.3 -C.sub.8 cycloalkyl; C.sub.2 -C.sub.12 alkenyl; C.sub.2 -C.sub.12 alkynyl; C.sub.1 -C.sub.12 halogenoalkyl or a group NR.sub.13 R.sub.14 ; in which R.sub.13 and R.sub.14 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl or together are tetra- or pentamethylene; R.sub.2 and R.sub.3 independently of one another are hydrogen; C.sub.1 -C.sub.8 alkyl; C.sub.1 -C.sub.8 alkyl which is substituted by hydroxyl, C.sub.1 -C.sub.4 alkoxy, mercapto or C.sub.1 -C.sub.4 alkylthio; C.sub.3 -C.sub.8 alkenyl; C.sub.3 -C.sub.8 alkynyl; C.sub.3 -C.sub.8 cycloalkyl or C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.4 alkyl, or in which the two groups R.sub.2 and R.sub.3, together with the carbon atom to which they are bonded, form a three- to eight-membered carbocyclic ring; R.sub.4 is hydrogen or C.sub.1 -C.sub.6 alkyl; R.sub.5 is hydrogen; C.sub.1 -C.sub.6 alkyl or phenyl, which is unsubstituted or can be substituted by halogen, nitro, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 halogenoalkyl, C.sub.1 -C.sub.4 alkoxy or C.sub.1 -C.sub.4 alkylthio; and R.sub.6 is a group G ##STR2## in which R.sub.7 and R.sub.8 independently of one another are hydrogen or C.sub.1 -C.sub.6 alkyl; p is the number zero or one; and R.sub.9, R.sub.10 and R.sub.11 independently of one another are hydrogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 halogenoalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.1 -C.sub.6 alkoxy, C.sub.3 -C.sub.6 alkenyloxy, C.sub.3 -C.sub.6 alkynyloxy, C.sub.3 -C.sub.6 alkylthio, halogen or nitro are valuable microbicides. They can be employed in crop protection in the form of suitable compositions, for example for controlling fungal diseases.

    摘要翻译： α型氨基酰胺，其中n是数字0或1; R 1是未被取代或可以被C 1 -C 4烷氧基，C 1 -C 4烷硫基，C 1 -C 4烷基磺酰基，C 3 -C 8环烷基，氰基，C 1 -C 6烷氧基羰基，C 3 -C 6烯氧基羰基或C 3 -C 6炔氧基羰基取代的C 1 -C 12烷基; C 3 -C 8环烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 1 -C 12卤代烷基或NR 13 R 14基团; 其中R 13和R 14彼此独立地是氢或C 1 -C 6烷基或一起是四或五亚甲基; R2和R3彼此独立地是氢; C1-C8烷基; 被羟基，C 1 -C 4烷氧基，巯基或C 1 -C 4烷硫基取代的C 1 -C 8烷基; C3-C8链烯基; C3-C8炔基; C 3 -C 8环烷基或C 3 -C 8环烷基-C 1 -C 4烷基，或其中两个基团R 2和R 3与它们所键合的碳原子一起形成三至八元碳环; R4是氢或C1-C6烷基; R5是氢; 硝基，C 1 -C 4烷基，C 1 -C 4卤代烷基，C 1 -C 4烷氧基或C 1 -C 4烷硫基取代的C 1 -C 6烷基或苯基; 并且R 6是基团G G，其中R 7和R 8彼此独立地是氢或C 1 -C 6烷基; p是数字0或1; 并且R 9，R 10和R 11彼此独立地是氢，C 1 -C 6烷基，C 1 -C 6卤代烷基，C 3 -C 6烯基，C 3 -C 6炔基，C 1 -C 6烷氧基，C 3 -C 6烯氧基，C 3 -C 6炔氧基，C 3 -C 6烷硫基，卤素或硝基是有价值的 杀菌剂 它们可以以合适的组合物的形式用于作物保护，例如用于防治真菌疾病。

    Carbocyclic sulfonamides
    17.
    发明授权
    Carbocyclic sulfonamides 失效
    碳环磺酰胺

    公开(公告)号：US6046236A

    公开(公告)日：2000-04-04

    申请号：US848833

    申请日：1997-05-05

    申请人： Nobuyuki Hamanaka ,  Tsumoru Miyamoto

    发明人： Nobuyuki Hamanaka ,  Tsumoru Miyamoto

    IPC分类号： A61K31/557 ,  A61P43/00 ,  C07C303/38 ,  C07C303/40 ,  C07C311/07 ,  C07C311/10 ,  C07C311/11 ,  C07C311/12 ,  C07C311/13 ,  C07C311/14 ,  C07C311/19 ,  C07C311/20 ,  C07C311/27 ,  C07C311/29 ,  C07D493/08 ,  A01N37/12 ,  A01N37/44 ,  A61K31/24

    CPC分类号： C07C311/19 ,  C07C311/07 ,  C07C311/10 ,  C07C311/11 ,  C07C311/13 ,  C07C311/14 ,  C07C311/20 ,  C07C311/27 ,  C07C311/29

    摘要： (1) Prostaglandin (PG) E.sub.2 antagonist or agonist containing carbocyclic sulfonamides represented by the compound of the formula (I): ##STR1## cyclodextrin clathrates thereof, non-toxic salts thereof as active ingredient,(2) carbocyclic sulfonamides represented by the compound of the formula (II): ##STR2## cyclodextrin clathrates thereof, non-toxic salts thereof, (3) process for the preparation of the compound represented by the compound of the formula (II) described hereinbefore,(4) PGE.sub.2 antagonist or agonist containing the compound represented by the compound of the formula (II) as active ingredient.The compounds represented by the compounds of the formula (I) and (II) can be adapted to medicines which possess an inhibitory effect of uterine contraction, an analgetic action, an inhibitory effect of digestive peristalsis, a sleep-inducing effect as PGE.sub.2 antagonists, and an uterine contractile activity, a promoting effect of digestive peristalsis, a suppressive effect of gastric acid secretion, a hypotensive activity as PGE.sub.2 agonists, because they bind onto PGE.sub.2 receptor and have an activity of antagonist or agonist against the action thereof.

    摘要翻译： （1）由式（I）化合物表示的前列腺素（PG）E2拮抗剂或含有碳环磺酰胺的激动剂：其环糊精包合物，其无毒性盐作为活性成分，（2）由下式表示的碳环磺酰胺 （II）：其环糊精包合物，其无毒盐，（3）由上述式（II）化合物表示的化合物的制备方法，（4）PGE2拮抗剂或含有由 式（II）的化合物作为活性成分。 由式（I）和（II）化合物表示的化合物可适用于具有子宫收缩抑制作用，止痛作用，消化性蠕动抑制作用，睡眠诱导作用PGE2拮抗剂的药物， 因为它们结合PGE2受体并且具有针对其作用的拮抗剂或激动剂的活性，因此其作为PGE2激动剂具有低血压活性，作为消化道蠕动的促进作用，胃酸分泌的抑制作用。