公开(公告)号：US20170227521A1

公开(公告)日：2017-08-10

申请号：US15015244

申请日：2016-02-04

Applicant: Nova Biomedical Corporation

Inventor： Michael S. Cafferty ,  Scott P. Cionek

IPC: G01N33/49 ,  G01N21/25 ,  G01N21/03

CPC classification number: G01N33/49 ,  G01J3/0202 ,  G01J3/0205 ,  G01J3/0208 ,  G01J3/0218 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/0297 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/42 ,  G01J2003/2866 ,  G01N21/0303 ,  G01N21/255 ,  G01N21/274 ,  G01N21/31 ,  G01N33/492 ,  G01N2021/0321 ,  G01N2021/0389 ,  G01N2201/062 ,  G01N2201/0633 ,  G01N2201/0634 ,  G01N2201/0638

Abstract: A system of measuring hemoglobin and bilirubin parameters in a whole blood sample using optical absorbance. The system includes an optical-sample module, a spectrometer module, an optical fiber module optically connecting the optical-sample module to the spectrometer module, and a processor module. The optical-sample module has a light-emitting module having a LED light source, a cuvette and a calibrating-light module. The processor module receives and processes an electrical signal from the spectrometer module and transforms the electrical signal into an output signal useable for displaying and reporting hemoglobin parameter values and/or total bilirubin parameter values for the whole blood sample.

公开(公告)号：US09726541B2

公开(公告)日：2017-08-08

申请号：US14975792

申请日：2015-12-20

Applicant: AB Elektronik Sachsen GmbH

Inventor： Aldo Bojarski ,  Klaus Erler ,  Katrin Künzelmann ,  Andre Legner ,  Paul Smith ,  Tobby Straβberger

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/14 ,  G01J3/10 ,  G01N21/41 ,  G01N21/27

CPC classification number: G01J3/2803 ,  G01J3/0291 ,  G01J3/10 ,  G01J3/14 ,  G01N21/27 ,  G01N21/4133 ,  G01N2201/0221 ,  G01N2201/0627

Abstract: A sensor for monitoring a medium has an electromagnetic radiation source, mirrors, and a detector for electromagnetic radiation arranged inside a cup-shaped housing part. The cup-shaped part has flat, angularly arranged wall areas defining a cavity in which, outside of the housing, the medium is contained. The flat wall areas are transparent for electromagnetic radiation and arranged in the beam path from the electromagnetic radiation source to the detector so that the electromagnetic radiation passes through first wall, medium in the cavity, and second wall. The first and second wall areas and the medium form a refracting prism. A cover closes off the cup-shaped part so that electromagnetic radiation source, detector, and mirrors are enclosed in the housing. A data processing system is connected to electromagnetic radiation source and detector so that electromagnetic radiation of different wavelengths is refracted in the prism and the resulting spectra are detected and evaluated.

公开(公告)号：US20170176338A1

公开(公告)日：2017-06-22

申请号：US15384918

申请日：2016-12-20

Applicant: Verily Life Sciences LLC

Inventor： Cheng-Hsun Wu ,  Victor Marcel Acosta ,  Ian Peikon ,  Paul Lebel ,  Jerrod Joseph Schwartz

IPC: G01N21/64 ,  G02B21/36 ,  G02B26/08 ,  G02B21/16 ,  G06T7/90 ,  G02F1/29

CPC classification number: G01N21/6458 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0224 ,  G01J3/0229 ,  G01J3/0237 ,  G01J3/08 ,  G01J3/14 ,  G01J3/18 ,  G01J3/2823 ,  G01J3/32 ,  G01J3/4406 ,  G01J2003/1213 ,  G01J2003/2826 ,  G01N21/6408 ,  G01N21/6428 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6463 ,  G01N2201/0633 ,  G01N2201/0675 ,  G02B5/1828 ,  G02B21/16 ,  G02B21/361 ,  G02B21/367 ,  G02B26/0808 ,  G02B26/0833 ,  G02F1/29 ,  G02F2201/34 ,  G02F2203/12 ,  G06T7/90 ,  G06T2207/10004 ,  G06T2207/10056

Abstract: Methods are provided to identify spatially and spectrally multiplexed probes in a biological environment. Such probes are identified by the ordering and color of fluorophores of the probes. The devices and methods provided facilitate determination of the locations and colors of such fluorophores, such that a probe can be identified. In some embodiments, probes are identified by applying light from a target environment to a spatial light modulator that can be used to control the direction and magnitude of chromatic dispersion of the detected light; multiple images of the target, corresponding to multiple different spatial light modulator settings, can be deconvolved and used to determine the colors and locations of fluorophores. In some embodiments, light from a region of the target can be simultaneously imaged spatially and spectrally. Correlations between the spatial and spectral images over time can be used to determine the color of fluorophores in the target.

公开(公告)号：US20170150888A1

公开(公告)日：2017-06-01

申请号：US15430517

申请日：2017-02-12

Applicant: Thomas Nathan Millikan

Inventor： Thomas Nathan Millikan

IPC: A61B5/00 ,  H04N7/18 ,  G06T7/90 ,  G01J3/02 ,  H04N5/232 ,  G01J3/28 ,  G01J3/36 ,  G01J1/58 ,  H04N5/33 ,  G06T7/00

CPC classification number: A61B5/0075 ,  A61B5/0071 ,  A61B5/0077 ,  A61B5/1112 ,  A61B5/743 ,  A61B2560/0242 ,  A61B2576/00 ,  G01J1/58 ,  G01J3/0208 ,  G01J3/0229 ,  G01J3/0264 ,  G01J3/027 ,  G01J3/10 ,  G01J3/14 ,  G01J3/2823 ,  G01J3/36 ,  G01J3/513 ,  G01J2003/1213 ,  G01J2003/2826 ,  G06T7/0012 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/10048 ,  G06T2207/30088 ,  G06T2207/30196 ,  H04N5/23293 ,  H04N5/332 ,  H04N7/18 ,  H04N7/183

Abstract: Multispectral images, including ultraviolet light and its interactions with ultraviolet light-interactive compounds, can be captured, processed, and represented to a user. Ultraviolet-light related information can be conveniently provided to a user to allow the user to have awareness of UV characteristics and the user's risk to UV exposure.

公开(公告)号：US09651533B2

公开(公告)日：2017-05-16

申请号：US14875709

申请日：2015-10-06

Applicant: OMNI MEDSCI, INC.

Inventor： Mohammed N. Islam

IPC: G01J5/20 ,  G01N33/15 ,  A61B5/1455 ,  A61B5/00 ,  G01J3/10 ,  G01J3/28 ,  G01J3/453 ,  G01N21/359 ,  A61B5/145 ,  G01N33/49 ,  H01S3/30 ,  G01J3/14 ,  G01J3/18

CPC classification number: A61B5/0088 ,  A61B5/0013 ,  A61B5/0022 ,  A61B5/0075 ,  A61B5/0086 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/4547 ,  A61B5/6801 ,  A61B5/7257 ,  A61B5/7405 ,  A61B5/742 ,  A61B2562/0233 ,  A61B2562/0238 ,  A61B2562/146 ,  A61B2576/02 ,  G01J3/0218 ,  G01J3/108 ,  G01J3/14 ,  G01J3/1838 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/42 ,  G01J3/453 ,  G01J2003/104 ,  G01J2003/1208 ,  G01J2003/2826 ,  G01M3/38 ,  G01N21/35 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/39 ,  G01N21/85 ,  G01N21/88 ,  G01N21/9508 ,  G01N33/02 ,  G01N33/025 ,  G01N33/15 ,  G01N33/442 ,  G01N33/49 ,  G01N2021/3595 ,  G01N2021/399 ,  G01N2201/061 ,  G01N2201/06113 ,  G01N2201/062 ,  G01N2201/08 ,  G01N2201/12 ,  G01N2201/129 ,  G06F19/00 ,  G16H40/67 ,  H01S3/0092 ,  H01S3/06758 ,  H01S3/302

Abstract: A measurement system includes a wearable measurement device for measuring one or more physiological parameters, including a light source comprising a plurality of light emitting diodes (LEDs) configured to generate an output optical beam with a near-infrared wavelength between 700 nanometers and 2500 nanometers. The light source is configured to increase signal-to-noise ratio by increasing a light intensity and pulse rate of the LEDs. The system includes a plurality of lenses configured to receive the output optical beam and to deliver an analysis output beam to a sample. The wearable measurement device includes a receiver configured to process the analysis output beam reflected or transmitted from the sample and to generate an output signal that may be transmitted to a remote device configured to process the received output status to generate processed data and to store the processed data.

公开(公告)号：US09638686B1

公开(公告)日：2017-05-02

申请号：US15015278

申请日：2016-02-04

Applicant: Nova Biomedical Corporation

Inventor： Michael S. Cafferty ,  Scott P. Cionek

IPC: G01N33/48 ,  G01N33/49 ,  G01N21/27 ,  G01N33/487

CPC classification number: G01N33/492 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/14 ,  G01J3/42 ,  G01N21/21 ,  G01N21/274 ,  G01N21/31 ,  G01N33/48792 ,  G01N2021/216 ,  G01N2201/0634

Abstract: A method of measuring whole-blood hemoglobin parameters includes providing a LED light source, guiding light having the spectral range from the LED light source along an optical path, providing a cuvette module with a sample receiving chamber, providing a pair of first and second optical diffusers disposed in the optical path where the cuvette module is disposed between the pair of first and second optical diffusers, guiding light from the cuvette module into an optical spectrometer, and processing an electrical signal from the spectrometer into an output signal useable for displaying and reporting hemoglobin parameter values and/or total bilirubin parameter values of the sample of whole blood.

公开(公告)号：US09599510B2

公开(公告)日：2017-03-21

申请号：US14488684

申请日：2014-09-17

Applicant: Cymer, LLC ,  ASML Netherlands B.V.

Inventor： Thomas P. Duffey ,  Herman Philip Godfried

IPC: G03B27/32 ,  G03B27/54 ,  G03B27/74 ,  H01S3/10 ,  H01S3/13 ,  G01J3/28 ,  G03F7/20 ,  G01J11/00 ,  G01J9/00 ,  G01J3/14 ,  G01J3/26 ,  G01J3/02

CPC classification number: G01J3/28 ,  G01J3/027 ,  G01J3/14 ,  G01J3/26 ,  G01J9/00 ,  G01J11/00 ,  G01J2003/2853 ,  G03F7/70041 ,  G03F7/70058 ,  G03F7/70575

Abstract: A method is described for estimating a spectral feature of a pulsed light beam produced by an optical source and directed toward a wafer of a lithography apparatus. The method includes receiving a set of N optical spectra of pulses of the light beam; saving the received N optical spectra to a saved set; transforming the optical spectra in the saved set to form a set of transformed optical spectra; averaging the transformed optical spectra to form an averaged spectrum; and estimating a spectral feature of the pulsed light beam based on the averaged spectrum.

公开(公告)号：US20170045441A1

公开(公告)日：2017-02-16

申请号：US15340615

申请日：2016-11-01

Applicant: ARCHIMEJ TECHNOLOGY

Inventor： Mejdi Nciri

IPC: G01N21/31

CPC classification number: G01N21/31 ,  G01J3/0208 ,  G01J3/10 ,  G01J3/14 ,  G01J3/42 ,  G01J3/4406 ,  G01J2003/1282 ,  G01N21/6458 ,  G01N21/83 ,  G01N33/49 ,  G01N2021/3129 ,  G01N2021/3196 ,  G01N2021/6417 ,  G02B27/1006

Abstract: The invention generally relates to methods for determining a concentration of at least one target analyte in a heterogeneous sample and methods for detecting a condition. In certain aspects, the inventions provides methods that involve illuminating a heterogeneous sample, such as a biological sample, including at least one target analyte with polychromatic light, receiving luminous data of the heterogeneous sample and the at least one target analyte with a detector without splitting the polychromatic light into individual wavelengths and generating spectral data therefrom. The spectral data is then converted into a concentration of the at least one target analyte in the biological sample by comparing the spectral data to a database comprising known spectra already associated with concentration levels.

Abstract translation: 本发明一般涉及用于确定异质样品中至少一种目标分析物的浓度的方法和用于检测病症的方法。 在某些方面，本发明提供了涉及照射诸如生物样品的异质样品（包括至少一种具有多色光的目标分析物）的方法，使用检测器接收异质样品和至少一种目标分析物的发光数据而不分裂 将多色光转换为单个波长并从其产生光谱数据。 然后通过将光谱数据与包括已经与浓度水平相关联的已知光谱的数据库进行比较，将光谱数据转换成生物样品中至少一种目标分析物的浓度。

公开(公告)号：US20160320306A1

公开(公告)日：2016-11-03

申请号：US15109390

申请日：2015-01-07

Applicant: COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

Inventor： Donald Ray HUFFMAN ,  John Alexander HUFFMAN

IPC: G01N21/64 ,  G02B21/16 ,  G01N15/14 ,  G01N21/65 ,  G01N21/71

CPC classification number: G01N21/6458 ,  G01J3/0208 ,  G01J3/14 ,  G01J3/18 ,  G01J3/4406 ,  G01J3/4412 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/65 ,  G01N21/718 ,  G01N21/85 ,  G01N2015/0065 ,  G01N2015/144 ,  G01N2015/1465 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/0612 ,  G01N2201/062 ,  G02B21/16

Abstract: Provided are inexpensive devices and methods for obtaining emission or scattering spectra of multiple particles simultaneously and for characterizing the particles based on their emission or scattering spectra. The disclosed devices and methods are useful for analyzing multiple particles to determine one or more characteristics of the particles, such as size, type, elastic scattering, fluorescence and/or Raman characteristics, for distinguishing between biological and non-biological particles, and for biomedical assaying applications. Laboratory or research grade spectroscopic devices are described. Smartphone-based spectroscopic devices are also described, where various components of a smartphone are used for data collection and analysis purposes.

Abstract translation: 提供了用于同时获得多个颗粒的发射或散射光谱并用于基于其发射或散射光谱表征颗粒的便宜的装置和方法。 所公开的装置和方法可用于分析多个颗粒以确定颗粒的一个或多个特性，例如尺寸，类型，弹性散射，荧光和/或拉曼特性，用于区分生物和非生物颗粒，以及用于生物医学 测定应用。 描述实验室或研究级分光装置。 还描述了基于智能手机的光谱装置，其中智能手机的各种组件用于数据收集和分析目的。

公开(公告)号：US20150355025A1

公开(公告)日：2015-12-10

申请号：US14488684

申请日：2014-09-17

Applicant: Cymer, LLC ,  ASML Netherlands B.V.

Inventor： Thomas P. Duffey ,  Herman Philip Godfried

IPC: G01J3/28 ,  G03F7/20 ,  G01J9/00

CPC classification number: G01J3/28 ,  G01J3/027 ,  G01J3/14 ,  G01J3/26 ,  G01J9/00 ,  G01J11/00 ,  G01J2003/2853 ,  G03F7/70041 ,  G03F7/70058 ,  G03F7/70575

Abstract: A method is described for estimating a spectral feature of a pulsed light beam produced by an optical source and directed toward a wafer of a lithography apparatus. The method includes receiving a set of N optical spectra of pulses of the light beam; saving the received N optical spectra to a saved set; transforming the optical spectra in the saved set to form a set of transformed optical spectra; averaging the transformed optical spectra to form an averaged spectrum; and estimating a spectral feature of the pulsed light beam based on the averaged spectrum.

Abstract translation: 描述了一种用于估计由光源产生并指向光刻设备的晶片的脉冲光束的光谱特征的方法。 该方法包括接收光束脉冲的一组N个光谱; 将接收到的N光谱保存到保存的集合; 转换保存集中的光谱，形成一组变换光谱; 对变换的光谱进行平均以形成平均光谱; 以及基于所述平均光谱估计所述脉冲光束的光谱特征。