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公开(公告)号：US20170307601A1
公开(公告)日：2017-10-26
申请号：US15638526
申请日：2017-06-30
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , John H. Leamon , Jeffrey T. Branciforte , Charles O. Stanwood
CPC classification number: G01N33/54366 , B01L3/502707 , B01L3/502723 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , G01N21/05 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2035/00158 , Y10T29/494
Abstract: A method for performing a combined protein and nucleic acid assay on a target captured by a capture agent, includes providing a microfluidic device having a microfluidic channel network having at least one microfluidic channel, the channel arranged to receive fluid, the device having at least two micro-particles disposed in fixed position in the channel, the micro-particles being functionalized with a capture agent for the assay, one of the micro-particles in the channel being functionalized with an antibody or antigen capture agent and another of the micro-particles being functionalized with a nucleic acid capture agent. In some embodiments, the network may have at least two microfluidic channels, each channel of the two channels arranged to receive portions of the same fluid and to be fluidicly isolatable from each other, the device having at least two micro-particles disposed in fixed position in the network channels, the micro-particles being functionalized with a capture agent, one of the micro-particles in one of the channels being functionalized with an antibody or antigen capture agent and another of the micro-particles in another of the channels being functionalized with a nucleic acid capture agent. The method may also include detecting both protein and nucleic acid present in an input sample using the respectively functionalized micro particles. In some embodiments, the micro particles may be micro-length tubes or glass nano reactors.
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12.发明申请公开(公告)号：US20170248621A1
公开(公告)日：2017-08-31
申请号：US15477902
申请日：2017-04-03
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , Jeffrey T. Branciforte , Charles O. Stanwood
CPC classification number: B01J19/0046 , B01J2219/00286 , B01J2219/00468 , B01J2219/005 , B01J2219/00511 , B01J2219/00522 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L2200/021 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/0631 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , G01N21/05 , G01N21/645 , G01N21/6458 , G01N33/54366 , G01N35/00029 , G01N2021/0346 , G01N2021/058 , G01N2035/00039 , G01N2035/00108 , G01N2035/00158 , G01N2035/00752 , Y10T29/494
Abstract: A method and system for heating and/or inspecting a portable microfluidic assay cartridge for performing an assay includes receiving the assay cartridge on a receiving region of a translatable table under automated control, heating the cartridge, during performance of the assay, with a planar radiant heater plate, the heater plate having an aperture through which an inspection axis extends, and/or inspecting the cartridge using an optical system constructed to inspect the cartridge along the inspection axis by reading a fluorescent light signal which passes through the aperture in the heater plate. In addition, the cartridge moves with movement of the translation table, and the heater plate and optical system may be stationary, and the inspection axis may be fixed.
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公开(公告)号：US09546932B2
公开(公告)日：2017-01-17
申请号：US14479291
申请日：2014-09-06
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , Jeffrey T. Branciforte , Charles O. Stanwood
IPC: G01N1/28 , B32B37/00 , B01L3/00 , B01J19/00 , G01N35/00 , B81C3/00 , G01N33/543 , G01N33/53 , G01N1/00
CPC classification number: G01N1/28 , B01J19/0046 , B01J2219/00468 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/0054 , B01J2219/00585 , B01J2219/00691 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B32B37/0076 , B81C3/001 , G01N35/00029 , G01N2001/002 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247
Abstract: A pneumatically driven portable assay cartridge having analyte capture regions associated with microfluidic channels within its interior, the portable cartridge having pneumatic ports clampable against pneumatic ports of an operating instrument for controlled application of positive pressure and vacuum to pneumatic operating channels within the cartridge, the cartridge having a well for receiving sample from a user and microfluidic channels that include pneumatically operated pistons and valves controllable by the pneumatic operating channels to cause all flows of the assay from the reservoirs through reaction regions within the cartridge to on-board waste reservoir during conduct of the assay.
Abstract translation: 气动驱动的便携式分析盒具有与其内部的微流体通道相关联的分析物捕获区域，便携式盒具有可夹紧操作仪器的气动端口的气动端口，用于控制向盒内的气动操作通道施加正压力和真空， 具有用于从用户接收样品的井和包括气动活塞的微流体通道和由气动操作通道控制的阀门的微流体通道，以使来自储存器的测定的所有流动通过筒内的反应区域进入到船上废物储存器 该测定。
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公开(公告)号：US10076752B2
公开(公告)日：2018-09-18
申请号：US15581526
申请日：2017-04-28
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , Jeffrey T. Branciforte , Charles O. Stanwood
CPC classification number: B01L3/502715 , B01L3/502707 , B01L3/50273 , B01L9/527 , B01L2200/027 , B01L2200/0689 , B01L2200/148 , B01L2200/16 , B01L2300/0636 , B01L2300/0819 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/168 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N33/54366 , G01N35/00712 , G01N2021/0346 , G01N2021/058 , G01N2021/6439 , G01N2035/00158 , Y10T29/494 , Y10T436/10
Abstract: A method of flowing a fluid with a tracer in a microfluidic channel of an assay device and detecting the tracer for determining the channel location or condition of the channel.
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公开(公告)号：US10022696B2
公开(公告)日：2018-07-17
申请号：US14479284
申请日：2014-09-06
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , Jeffrey T. Branciforte , Charles O. Stanwood
Abstract: A method of making an assay device comprising providing micro-elements in the form of micro-particles or micro-length tube detection elements and thereafter with an automated tool, picking and placing the micro-elements into open-sided microfluidic channels in a body.
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Patent Agency Ranking
公开(公告)号：US09759718B2
公开(公告)日：2017-09-12
申请号：US14479288
申请日：2014-09-06
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , John H. Leamon , Jeffrey T. Branciforte , Charles O. Stanwood
CPC classification number: G01N33/54366 , B01L3/502707 , B01L3/502723 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , G01N21/05 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2035/00158 , Y10T29/494
Abstract: A microfluidic device comprising a microfluidic channel network sealed on one side by a membrane sheet, the sheet having PDMS defining at least the surface sealing the channel, the membrane sheet on its opposite side sealing one side of a pneumatic channel, the pneumatic channel arranged to enable pneumatic deflection of a deflectable portion of the membrane sheet into contact with an opposed surface to control flow in a channel of the network, the membrane sheet confining in a channel of the network at least one micro-particle, micro-length tube or glass nano reactor, functionalized with a capture agent, that has been inserted into that channel. A microfluidic device having a microfluidic channel containing at least two micro-particles, micro-length tubes or glass nano reactors, one functionalized with nucleic acid and another with antibody or antigen. A microfluidic device having a microfluidic channel containing at least one micro-length tube or glass nano reactor functionalized to capture nucleic acid, the device constructed to enable recovery of the nucleic acid captured by the device.
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公开(公告)号：US09651568B2
公开(公告)日：2017-05-16
申请号：US14479290
申请日：2014-09-06
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , Jeffrey T. Branciforte , Charles O. Stanwood
CPC classification number: B01J19/0046 , B01J2219/00286 , B01J2219/00468 , B01J2219/005 , B01J2219/00511 , B01J2219/00522 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L2200/021 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/0631 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , G01N21/05 , G01N21/645 , G01N21/6458 , G01N33/54366 , G01N35/00029 , G01N2021/0346 , G01N2021/058 , G01N2035/00039 , G01N2035/00108 , G01N2035/00158 , G01N2035/00752 , Y10T29/494
Abstract: An operating and reading instrument for performing an assay employing a portable microfluidic assay cartridge, the instrument comprising a translatable table under automated control, the translatable table carrying a receiving region for the portable cartridge and carrying a port system connectable to the cartridge that includes at least one remotely automated valve carried by the translatable table, the valve arranged to apply pressurized flowable substance at selected times to the cartridge while the cartridge is on the translatable table.
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18.发明申请PDMS Membrane-Confined Nucleic Acid and Antibody/Antigen-Functionalized Microlength Tube Capture Elements, and Systems Employing Them 有权PDMS膜受限制的核酸和抗体/抗原功能化的长度管捕获元件，以及使用它们的系统公开(公告)号：US20150087559A1
公开(公告)日：2015-03-26
申请号：US14479288
申请日：2014-09-06
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , John H. Leamon , Jeffrey T. Branciforte , Charles O. Stanwood
IPC: G01N33/543 , B01L3/00
CPC classification number: G01N33/54366 , B01L3/502707 , B01L3/502723 , B01L3/502738 , B01L3/502761 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , G01N21/05 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2035/00158 , Y10T29/494
Abstract: A microfluidic device comprising a microfluidic channel network sealed on one side by a membrane sheet, the sheet having PDMS defining at least the surface sealing the channel, the membrane sheet on its opposite side sealing one side of a pneumatic channel, the pneumatic channel arranged to enable pneumatic deflection of a deflectable portion of the membrane sheet into contact with an opposed surface to control flow in a channel of the network, the membrane sheet confining in a channel of the network at least one micro-particle, micro-length tube or glass nano reactor, functionalized with a capture agent, that has been inserted into that channel. A microfluidic device having a microfluidic channel containing at least two micro-particles, micro-length tubes or glass nano reactors, one functionalized with nucleic acid and another with antibody or antigen. A microfluidic device having a microfluidic channel containing at least one micro-length tube or glass nano reactor functionalized to capture nucleic acid, the device constructed to enable recovery of the nucleic acid captured by the device.
Abstract translation: 一种微流体装置，包括通过膜片在一侧密封的微流体通道网，所述片材具有至少限定密封通道的表面，所述膜片在其相对侧密封气动通道的一侧，所述气动通道布置成 使得膜片的可偏转部分的气动偏转与相对表面接触以控制网络的通道中的流动，所述膜片限定在网络的通道中，至少一个微粒子，微长度管或玻璃 纳米反应器，其已被插入该通道中用捕获剂官能化。 具有微流体通道的微流体装置，其包含至少两个微粒子，微管或玻璃纳米反应器，一个用核酸功能化，另一个用抗体或抗原功能化。 具有微流体通道的微流体装置，该微流体通道含有至少一个用于捕获核酸的微管或玻璃纳米反应器，该反应器被构造成能够回收由该装置捕获的核酸。
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19.发明申请Microfluidic Assay Systems Employing Micro-Particles and Methods of Manufacture 有权使用微粒子的微流控测定系统和制造方法公开(公告)号：US20150087558A1
公开(公告)日：2015-03-26
申请号：US14479284
申请日：2014-09-06
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , Jeffrey T. Branciforte , Charles O. Stanwood
CPC classification number: B01J19/0046 , B01J2219/00286 , B01J2219/00468 , B01J2219/005 , B01J2219/00511 , B01J2219/00522 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00689 , B01J2219/00691 , B01L3/502707 , B01L3/502715 , B01L3/502738 , B01L2200/021 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/0631 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2300/168 , B01L2300/1805 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0638 , B01L2400/0655 , B01L2400/086 , G01N21/05 , G01N21/645 , G01N21/6458 , G01N33/54366 , G01N35/00029 , G01N2021/0346 , G01N2021/058 , G01N2035/00039 , G01N2035/00108 , G01N2035/00158 , G01N2035/00752 , Y10T29/494
Abstract: A method of making an assay device comprising providing micro-elements in the form of micro-particles or micro-length tube detection elements and thereafter with an automated tool, picking and placing the micro-elements into open-sided microfluidic channels in a body.
Abstract translation: 一种制备测定装置的方法，包括以微粒或微量长度管检测元件的形式提供微元件，此后用自动化工具拾取并将微元件放置在体内的开放式微流体通道中。
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公开(公告)号：US20140377146A1
公开(公告)日：2014-12-25
申请号：US14479291
申请日：2014-09-06
Applicant: CyVek, Inc.
Inventor： Martin A. Putnam , Jeffrey T. Branciforte , Charles O. Stanwood
IPC: G01N1/28
CPC classification number: G01N1/28 , B01J19/0046 , B01J2219/00468 , B01J2219/00511 , B01J2219/0052 , B01J2219/00522 , B01J2219/0054 , B01J2219/00585 , B01J2219/00691 , B01J2219/00725 , B01J2219/0074 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/027 , B01L2200/0689 , B01L2200/16 , B01L2300/0636 , B01L2300/0816 , B01L2300/0838 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0481 , B01L2400/0638 , B01L2400/0655 , B32B37/0076 , B81C3/001 , G01N35/00029 , G01N2001/002 , G01N2035/00148 , G01N2035/00158 , G01N2035/00247
Abstract: A pneumatically driven portable assay cartridge having analyte capture regions associated with microfluidic channels within its interior, the portable cartridge having pneumatic ports clampable against pneumatic ports of an operating instrument for controlled application of positive pressure and vacuum to pneumatic operating channels within the cartridge, the cartridge having a well for receiving sample from a user and microfluidic channels that include pneumatically operated pistons and valves controllable by the pneumatic operating channels to cause all flows of the assay from the reservoirs through reaction regions within the cartridge to on-board waste reservoir during conduct of the assay.
Abstract translation: 气动驱动的便携式分析盒具有与其内部的微流体通道相关联的分析物捕获区域，便携式盒具有可夹紧操作仪器的气动端口的气动端口，用于控制向盒内的气动操作通道施加正压力和真空， 具有用于从用户接收样品的井和包括气动活塞的微流体通道和由气动操作通道控制的阀门的微流体通道，以使来自储存器的测定的所有流动通过筒内的反应区域进入到船上废物储存器 该测定。
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