知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

29 records (took 0.033 seconds)

    Humanized antibodies against vascular endothelial growth factor
    11.
    发明授权
    Humanized antibodies against vascular endothelial growth factor 失效
    针对血管内皮生长因子的人源化抗体

    公开(公告)号：US07667004B2

    公开(公告)日：2010-02-23

    申请号：US10723434

    申请日：2003-11-26

    Applicant: Pingyu Zhong ,  Peizhi Luo ,  Kevin C. Wang ,  Mark Hsieh ,  Yan Li

    Inventor： Pingyu Zhong ,  Peizhi Luo ,  Kevin C. Wang ,  Mark Hsieh ,  Yan Li

    IPC: C12P21/08

    CPC classification number: C07K16/00 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/00725 ,  C07K16/22 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2319/00 ,  C40B40/10 ,  Y02A90/26

    Abstract: Methods are provided for designing and selecting antibodies against human antigens with high affinity and specificity in silico and in vitro. In some particular embodiments, methods are provided for designing and selecting humanized or fully human antibodies against vascular endothelial growth factor (VEGF) with high affinity and specificity. In another aspect of the invention, monoclonal antibodies against VEGF are provided. In particular, humanized or human anti-VEGF monoclonal antibodies are provided with ability to bind to human VEGF with high affinity, inhibit VEGF-induced proliferation of endothelial cells in vitro and inhibit VEGF-induced angiogenesis in vivo. These antibodies and their derivative can be used in a wide variety of applications such as diagnosis, prevention, and treatment of diseases such as cancer, AMD, diabetic retinopathy, and other diseases derived from pathological angiogenesis.

    Abstract translation: 提供了用于在计算机和体外以高亲和力和特异性设计和选择针对人抗原的抗体的方法。 在一些具体实施方案中，提供了用于以高亲和力和特异性设计和选择针对血管内皮生长因子（VEGF）的人源化或完全人抗体的方法。 在本发明的另一方面，提供了针对VEGF的单克隆抗体。 特别地，人源化或人抗VEGF单克隆抗体具有以高亲和力结合人VEGF的能力，在体外抑制VEGF诱导的内皮细胞增殖并抑制体内VEGF诱导的血管生成。 这些抗体及其衍生物可用于广泛的应用，例如诊断，预防和治疗诸如癌症，AMD，糖尿病性视网膜病和其它源于病理血管发生的疾病。

    Cross-Species and Multi-Species Display Systems
    12.
    发明申请
    Cross-Species and Multi-Species Display Systems 审中-公开
    交叉物种和多物种显示系统

    公开(公告)号：US20090082221A1

    公开(公告)日：2009-03-26

    申请号：US12226933

    申请日：2007-05-03

    Applicant: Kevin Caili Wang ,  Pingyu Zhong ,  Peter Peizhi Luo

    Inventor： Kevin Caili Wang ,  Pingyu Zhong ,  Peter Peizhi Luo

    IPC: C40B40/02 ,  C12N1/19

    CPC classification number: C12N15/1037 ,  C12N15/74 ,  C12N15/79

    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for multi-species and cross-species display of polypeptides on the outer surface of prokaryotic genetic packages and/or eukaryotic host cells. The multi-species and cross-species display systems can be practiced using the vector sets of the invention without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of phage, bacterial host cells, yeast cells, and mammalian cells.

    Abstract translation: 本发明提供了可以各种组合使用的表达载体和辅助显示载体，作为在原核遗传包和/或真核宿主细胞的外表面上的多物种和多物种展示多肽的载体集。 可以使用本发明的向量集来实现多种和跨物种显示系统，而不必改变或重新设计显示向量。 本发明的显示系统特别可用于在噬菌体，细菌宿主细胞，酵母细胞和哺乳动物细胞的表面上显示遗传多样的多肽或多肽文库。

    Compositions and methods for generating chimeric heteromultimers
    13.
    发明授权
    Compositions and methods for generating chimeric heteromultimers 有权
    用于产生嵌合异源多聚体的组合物和方法

    公开(公告)号：US07429652B2

    公开(公告)日：2008-09-30

    申请号：US10911127

    申请日：2004-08-03

    Applicant: Caili Wang ,  Pingyu Zhong ,  Shengjiang Liu ,  Peizhi Luo ,  Shengfeng Li ,  Xinwei Wang

    Inventor： Caili Wang ,  Pingyu Zhong ,  Shengjiang Liu ,  Peizhi Luo ,  Shengfeng Li ,  Xinwei Wang

    IPC: C07H21/04 ,  C12Q1/70 ,  C12P21/04 ,  C12N7/00 ,  C12N15/00 ,  C12N5/06 ,  A61K39/395 ,  C12P21/08

    CPC classification number: C07K16/00 ,  C07K2317/56 ,  C07K2319/00

    Abstract: The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.

    Abstract translation: 本发明提供了用于特异性组装单体多肽以形成异源多聚体的技术。 该技术对于产生诸如抗原结合单位的异源多聚体的遗传多样性谱特别有用。 本发明还提供通过本文所述技术组装的非单链和单链抗原结合单元。 本发明还提供重组多核苷酸，载体，宿主细胞和用于产生受试者抗原结合单位的试剂盒。 本发明进一步提供的是使用受试者抗原结合单元的方法。

    Structure-based screening techniques for drug discovery
    14.
    发明授权
    Structure-based screening techniques for drug discovery 失效
    基于结构的药物发现筛选技术

    公开(公告)号：US06864359B1

    公开(公告)日：2005-03-08

    申请号：US09502984

    申请日：2000-02-11

    Applicant: Peizhi Luo

    Inventor： Peizhi Luo

    IPC: A61K35/14 ,  A61K38/00 ,  A61K38/16 ,  C07K1/00 ,  C07K14/71

    CPC classification number: C07K14/71 ,  A61K38/00

    Abstract: The invention relates to novel non-naturally occurring cell surface receptor analogs, ligand analogs and nucleic acids encoding them. The invention further provides methods for screening of ligand analogs and bioactive agents capable of modulating the signaling activity of a non-naturally occurring cell surface receptor analog or capable of binding to a non-naturally occurring cell surface receptor analog.

    Abstract translation: 本发明涉及新型非天然存在的细胞表面受体类似物，配体类似物和编码它们的核酸。 本发明还提供了筛选能够调节非天然存在的细胞表面受体类似物的信号活性或能够结合非天然存在的细胞表面受体类似物的配体类似物和生物活性剂的方法。

    Dynamic human heavy chain antibody libraries
    16.
    发明授权
    Dynamic human heavy chain antibody libraries 有权

    公开(公告)号：US11578426B2

    公开(公告)日：2023-02-14

    申请号：US16640679

    申请日：2017-08-21

    Applicant: Adagene Inc. ,  Peter Peizhi Luo

    Inventor： Peter Peizhi Luo ,  Yan Li ,  Fangyong Du

    IPC: C40B40/08 ,  C07K16/00 ,  C40B50/04

    Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

    Eukaryotic cell display systems
    18.
    发明授权
    Eukaryotic cell display systems 有权
    真核细胞显示系统

    公开(公告)号：US08637435B2

    公开(公告)日：2014-01-28

    申请号：US12291889

    申请日：2008-11-14

    Applicant: Kevin Caili Wang ,  Peter Peizhi Luo ,  Pingyu Zhong ,  Jian Wang

    Inventor： Kevin Caili Wang ,  Peter Peizhi Luo ,  Pingyu Zhong ,  Jian Wang

    IPC: C40B40/02 ,  C40B50/06

    CPC classification number: C12N15/1037 ,  C40B40/02

    Abstract: The present invention provides expression vectors and helper display vectors which can be used in various combinations as vector sets for display of polypeptides on the outer surface of eukaryotic host cells. The expression vector of the invention can be used alone for soluble expression without having to change or reengineer the display vectors. The display systems of the invention are particularly useful for displaying a genetically diverse repertoire or library of polypeptides on the surface of yeast cells, and mammalian cells.

    Abstract translation: 本发明提供了可用于各种组合的表达载体和辅助显示载体，作为用于在真核宿主细胞的外表面上显示多肽的载体组。 本发明的表达载体可以单独用于可溶性表达，而不必改变或重新构建显示载体。 本发明的显示系统特别可用于在酵母细胞和哺乳动物细胞的表面上显示遗传多样的多肽或多肽文库。

    Structure-based construction of human antibody library
    19.
    发明申请
    Structure-based construction of human antibody library 审中-公开
    基于结构的人抗体库构建

    公开(公告)号：US20110257044A1

    公开(公告)日：2011-10-20

    申请号：US12316675

    申请日：2008-12-16

    Applicant: Peizhi Luo ,  Mark Hsieh

    Inventor： Peizhi Luo ,  Mark Hsieh

    IPC: C40B50/02 ,  G06F19/10 ,  C40B50/06

    CPC classification number: C40B40/10 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/00725 ,  C07K16/00 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2319/00 ,  C12N15/1089 ,  G16B35/00 ,  G16C20/60

    Abstract: Methods and systems are provided for constructing recombinant antibody libraries based on three-dimensional structures of antibodies from various species including human. In one aspect, a library of antibodies with diverse sequences is efficiently constructed in silico to represent the structural repertoire of the vertebrate antibodies. Such a functionally representative library provides a structurally diverse and yet functionally more relevant source of antibody candidates which can then be screened for high affinity binding to a wide variety of target molecules, including but not limited to biomacromolecules such as protein, peptide, and nucleic acids, and small molecules.

    Abstract translation: 提供了基于来自包括人在内的各种物种的抗体的三维结构构建重组抗体文库的方法和系统。 在一个方面，具有不同序列的抗体文库有效地构建成计算机以表示脊椎动物抗体的结构谱。 这样的功能代表性的文库提供了结构上多样但功能上更相关的抗体候选来源，然后可以筛选其与多种靶分子的高亲和力结合，包括但不限于生物大分子如蛋白质，肽和核酸 ，和小分子。

Patent Agency Ranking