公开(公告)号：US20240150749A1

公开(公告)日：2024-05-09

申请号：US18153221

申请日：2023-01-11

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong Du

IPC: C12N15/10 ,  A61P35/00 ,  C07K16/28 ,  C40B10/00 ,  C40B40/02 ,  C40B40/08 ,  C40B40/10

CPC classification number: C12N15/1037 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2878 ,  C40B10/00 ,  C40B40/02 ,  C40B40/08 ,  C40B40/10 ,  A61K2039/505

Abstract: Provided herein are libraries containing synthetic polynucleotides that encode activatable binding polypeptides. Further provided herein are activatable binding polypeptides and polypeptide libraries containing such activatable binding polypeptides. Also provided herein are vectors, vector libraries, cells, kits, and methods of making and using activatable polypeptide libraries.

公开(公告)号：US11585014B2

公开(公告)日：2023-02-21

申请号：US16640673

申请日：2017-08-21

Applicant: Adagene Inc.

Inventor： Peter Peizhi Luo ,  Yan Li ,  Fangyong Du

IPC: C40B40/08 ,  C07K16/00 ,  C40B30/04

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody light chain with specific hypervariable regions HVR-L1, HVR-L2, and HVR-L3. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody light chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US11242395B2

公开(公告)日：2022-02-08

申请号：US16108018

申请日：2018-08-21

Applicant: Adagene Inc.

Inventor： Peter Peizhi Luo ,  Fangyong Du ,  Yan Li ,  Guizhong Liu ,  Jun Chen ,  Xiaohong She ,  Peter Cheung

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61P35/00 ,  A61K45/06

Abstract: The present disclosure provides antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.

公开(公告)号：US20190241662A1

公开(公告)日：2019-08-08

申请号：US16265946

申请日：2019-02-01

Applicant: ADAGENE INC.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Zhongzong PAN ,  Guizhong LIU

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  C12N5/0783 ,  C12N5/071

CPC classification number: C07K16/2818 ,  A61K45/06 ,  A61P35/00 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/92 ,  C12N5/0638 ,  C12N5/0682 ,  G01N33/574

Abstract: Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).

公开(公告)号：US20160145604A1

公开(公告)日：2016-05-26

申请号：US14774722

申请日：2013-03-14

Applicant: ADAGENE INC.

Inventor： Fangyong Du ,  Peter Peizhi Luo

IPC: C12N15/10 ,  C07K14/00 ,  C07K16/00

CPC classification number: C12N15/1037 ,  C07K14/00 ,  C07K16/00 ,  C12N15/1058

Abstract: A recombinant polynucleotide suitable for use in a display vector is provided. The recombinant polynucleotide includes from 5′ to 3′: a first nucleic acid sequence (or insert) encoding an amino acid sequence to be displayed on a surface; a first pre-selected restriction site; a second nucleic acid sequence encoding a surface peptide capable of being displayed on the surface; and a second pre-selected restriction site. Corresponding display vectors that can be converted into expression vectors in a high-throughput fashion, as well as methods of use thereof, are also provided.

Abstract translation: 提供了适用于显示载体的重组多核苷酸。 重组多核苷酸包括5'至3'：编码要在表面上显示的氨基酸序列的第一核酸序列（或插入片段） 第一个预先选择的限制性位点; 编码能够在表面上显示的表面肽的第二核酸序列; 和第二预先选择的限制性位点。 还提供了可以以高通量方式转换为表达载体的相应显示向量及其使用方法。

公开(公告)号：US20240240358A1

公开(公告)日：2024-07-18

申请号：US18153070

申请日：2023-01-11

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C07K16/00 ,  C40B50/04

CPC classification number: C40B40/08 ,  C07K16/00 ,  C40B50/04 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/565

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US20240141046A1

公开(公告)日：2024-05-02

申请号：US18320146

申请日：2023-05-18

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Zhongzong PAN ,  Guizhong LIU

IPC: C07K16/28 ,  A61K31/713 ,  A61P35/00 ,  C12N5/071 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/63 ,  G01N33/574

CPC classification number: C07K16/2818 ,  A61K31/713 ,  A61P35/00 ,  C07K16/2809 ,  C12N5/0638 ,  C12N5/0682 ,  C12N5/10 ,  C12N15/63 ,  G01N33/574 ,  A61K2039/505

Abstract: Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).

公开(公告)号：US20210206855A1

公开(公告)日：2021-07-08

申请号：US16966844

申请日：2019-02-02

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Zhongzong PAN ,  Guizhong LIU

IPC: C07K16/28 ,  A61P35/00

Abstract: Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).

公开(公告)号：US20240209092A1

公开(公告)日：2024-06-27

申请号：US18554870

申请日：2022-04-11

Applicant: ADAGENE INC.

Inventor： Peter Peizhi LUO ,  Guizhong LIU

IPC: C07K16/28 ,  A61K31/337 ,  A61K31/502 ,  A61K31/7048 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00

CPC classification number: C07K16/2818 ,  A61K31/337 ,  A61K31/502 ,  A61K31/7048 ,  A61K39/3955 ,  A61P35/00 ,  C07K16/2878 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2319/30

Abstract: Provided herein are compositions and methods for treating cancers using anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA4) antibodies, such as activatable anti-CTLA4 antibodies. In some embodiments, combination therapies including an anti-CT-LA4 antibody and an immune checkpoint inhibitor, an anti-CD137 antibody, a vascular endothelial growth factor (VEGF) inhibitor, a chemotherapeutic agent, or a poly ADP ribose polymerase (PARP) inhibitor are provided.

公开(公告)号：US20230287597A1

公开(公告)日：2023-09-14

申请号：US18153067

申请日：2023-01-11

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C07K16/00 ,  C40B30/04

CPC classification number: C40B40/08 ,  C07K16/005 ,  C40B30/04 ,  C07K2317/31 ,  C07K2317/565

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody light chain with specific hypervariable regions HVR-L1, HVR-L2, and HVR-L3. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody light chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.