公开(公告)号：US20190241662A1

公开(公告)日：2019-08-08

申请号：US16265946

申请日：2019-02-01

Applicant: ADAGENE INC.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Zhongzong PAN ,  Guizhong LIU

IPC: C07K16/28 ,  A61P35/00 ,  G01N33/574 ,  C12N5/0783 ,  C12N5/071

CPC classification number: C07K16/2818 ,  A61K45/06 ,  A61P35/00 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/732 ,  C07K2317/92 ,  C12N5/0638 ,  C12N5/0682 ,  G01N33/574

Abstract: Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).

公开(公告)号：US20240240358A1

公开(公告)日：2024-07-18

申请号：US18153070

申请日：2023-01-11

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C07K16/00 ,  C40B50/04

CPC classification number: C40B40/08 ,  C07K16/00 ,  C40B50/04 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/565

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US20240141046A1

公开(公告)日：2024-05-02

申请号：US18320146

申请日：2023-05-18

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Zhongzong PAN ,  Guizhong LIU

IPC: C07K16/28 ,  A61K31/713 ,  A61P35/00 ,  C12N5/071 ,  C12N5/0783 ,  C12N5/10 ,  C12N15/63 ,  G01N33/574

CPC classification number: C07K16/2818 ,  A61K31/713 ,  A61P35/00 ,  C07K16/2809 ,  C12N5/0638 ,  C12N5/0682 ,  C12N5/10 ,  C12N15/63 ,  G01N33/574 ,  A61K2039/505

Abstract: Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).

公开(公告)号：US20210206855A1

公开(公告)日：2021-07-08

申请号：US16966844

申请日：2019-02-02

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Zhongzong PAN ,  Guizhong LIU

IPC: C07K16/28 ,  A61P35/00

Abstract: Provided herein are cross-reactive antibodies (or antigen binding fragments thereof) that bind to human CTLA4, activatable antibodies that bind to human CTLA4, nucleic acid molecules encoding the same, pharmaceutical compositions thereof, and methods of their therapeutic use (e.g., for treatment of cancer).

公开(公告)号：US20230287597A1

公开(公告)日：2023-09-14

申请号：US18153067

申请日：2023-01-11

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C07K16/00 ,  C40B30/04

CPC classification number: C40B40/08 ,  C07K16/005 ,  C40B30/04 ,  C07K2317/31 ,  C07K2317/565

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody light chain with specific hypervariable regions HVR-L1, HVR-L2, and HVR-L3. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody light chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US20220204637A1

公开(公告)日：2022-06-30

申请号：US17564022

申请日：2021-12-28

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Yan LI ,  Guizhong LIU ,  Jun CHEN ,  Xiaohong SHE ,  Peter CHEUNG

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00

Abstract: The present disclosure provides antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.

公开(公告)号：US20200248336A1

公开(公告)日：2020-08-06

申请号：US16640679

申请日：2017-08-21

Applicant: Peter Peizhi LUO ,  Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C40B50/04 ,  C07K16/00

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US20200369776A1

公开(公告)日：2020-11-26

申请号：US16640684

申请日：2018-08-21

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Guizhong LIU ,  Yan LI ,  Jun CHEN ,  Xiaohong SHE ,  Peter CHEUNG

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: Provided are antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.

公开(公告)号：US20220090053A1

公开(公告)日：2022-03-24

申请号：US17540159

申请日：2021-12-01

Applicant: Adagene Inc.

Inventor： Fangyong DU ,  Peter Peizhi LUO

IPC: C12N15/10 ,  C07K14/00 ,  C07K16/00

Abstract: A recombinant polynucleotide suitable for use in a display vector is provided. The recombinant polynucleotide includes from 5′ to 3′: a first nucleic acid sequence (or insert) encoding an amino acid sequence to be displayed on a surface; a first pre-selected restriction site; a second nucleic acid sequence encoding a surface peptide capable of being displayed on the surface; and a second pre-selected restriction site. Corresponding display vectors that can be converted into expression vectors in a high-throughput fashion, as well as methods of use thereof, are also provided.

公开(公告)号：US20210207126A1

公开(公告)日：2021-07-08

申请号：US16966848

申请日：2019-02-02

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU

IPC: C12N15/10 ,  C07K16/28 ,  A61P35/00

Abstract: Provided herein are libraries containing synthetic polynucleotides that encode activatable binding polypeptides. Further provided herein are activatable binding polypeptides and polypeptide libraries containing such activatable binding polypeptides. Also provided herein are vectors, vector libraries, cells, kits, and methods of making and using activatable polypeptide libraries.