公开(公告)号：US20200248336A1

公开(公告)日：2020-08-06

申请号：US16640679

申请日：2017-08-21

Applicant: Peter Peizhi LUO ,  Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C40B50/04 ,  C07K16/00

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US20230287597A1

公开(公告)日：2023-09-14

申请号：US18153067

申请日：2023-01-11

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C07K16/00 ,  C40B30/04

CPC classification number: C40B40/08 ,  C07K16/005 ,  C40B30/04 ,  C07K2317/31 ,  C07K2317/565

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody light chain with specific hypervariable regions HVR-L1, HVR-L2, and HVR-L3. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody light chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US20220204637A1

公开(公告)日：2022-06-30

申请号：US17564022

申请日：2021-12-28

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Yan LI ,  Guizhong LIU ,  Jun CHEN ,  Xiaohong SHE ,  Peter CHEUNG

IPC: C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K39/00

Abstract: The present disclosure provides antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.

公开(公告)号：US20240240358A1

公开(公告)日：2024-07-18

申请号：US18153070

申请日：2023-01-11

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Yan LI ,  Fangyong DU

IPC: C40B40/08 ,  C07K16/00 ,  C40B50/04

CPC classification number: C40B40/08 ,  C07K16/00 ,  C40B50/04 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/565

Abstract: Provided herein are libraries containing polynucleotides, where one of the polynucleotides encodes an antibody heavy chain with specific hypervariable regions HVR-H1 and HVR-H2. Further provided herein are libraries containing polynucleotides encoding a plurality of unique antibodies, wherein each antibody comprises a heavy chain variable region and a light chain variable region. Also provided are antibodies, polypeptide libraries, vector libraries, cells, non-human animals, antibody heavy chains, methods of making an antibody library, kits, and methods of generating a bispecific antibody related thereto.

公开(公告)号：US20200369776A1

公开(公告)日：2020-11-26

申请号：US16640684

申请日：2018-08-21

Applicant: Adagene Inc.

Inventor： Peter Peizhi LUO ,  Fangyong DU ,  Guizhong LIU ,  Yan LI ,  Jun CHEN ,  Xiaohong SHE ,  Peter CHEUNG

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00

Abstract: Provided are antibodies that bind to human CD137 or antigen binding fragments thereof, nucleic acid encoding the same, therapeutic compositions thereof, and their use to enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, such as tumor immunity, and for the treatment of cancer.