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公开(公告)号：US20110039851A1
公开(公告)日：2011-02-17
申请号：US12738087
申请日：2008-10-14
申请人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
发明人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
IPC分类号： A61K31/5375 , C07C233/87 , C07C233/66 , C07D257/04 , C07D307/79 , C07C255/60 , C07D213/82 , C07D401/04 , C07D213/56 , C07D277/30 , C07D239/26 , C07D249/06 , C07D213/80 , C07C237/30 , C07D265/30 , C07C323/63 , A61K31/195 , A61K31/41 , A61K31/343 , A61K31/277 , A61K31/44 , A61K31/4439 , A61K31/4402 , A61K31/426 , A61K31/505 , A61K31/4192 , A61K31/4406 , A61K31/166 , A61K31/24 , A61P17/06 , A61P17/00 , A61P11/06 , A61P37/02
CPC分类号： C07D249/06 , C07C235/60 , C07C235/62 , C07C2601/02 , C07D239/26 , C07D257/04
摘要： The invention relates to a compound of formula (I): or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物或其互变异构体或其药学上可接受的盐，其中R 1至R 11，W，X，Y，Z和n如本文所定义。 本发明还涉及使用式（I）化合物及其组合物来治疗患者的各种疾病和病症的方法。 本发明还涉及制备式（I）化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US07470692B2
公开(公告)日：2008-12-30
申请号：US11209234
申请日：2005-08-23
申请人： Donghong Amy Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
发明人： Donghong Amy Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
IPC分类号： C07D403/12 , C07D403/14 , A61K31/501
CPC分类号： C07D487/04 , C07D209/10 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/08
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
摘要翻译： 公开了抑制参与炎症过程的细胞因子产生的式（I）化合物，因此可用于治疗涉及炎症的疾病和病理状况，例如慢性炎性疾病。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。
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![Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/12/29/US20050288285A1/abs.jpg.150x150.jpg)
13.发明申请Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US20050288285A1
公开(公告)日：2005-12-29
申请号：US11206707
申请日：2005-08-18
申请人： Charles Cywin , Zhidong Chen , Roman Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Marshall , Peter Nemoto , Ronald Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
发明人： Charles Cywin , Zhidong Chen , Roman Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Marshall , Peter Nemoto , Ronald Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
IPC分类号： A61K31/38 , A61K31/435 , A61K31/4365 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P39/00 , A61P43/00 , C07B61/00 , C07D495/04 , C07D519/00 , C07D498/02 , A61K31/4743
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US06689804B2
公开(公告)日：2004-02-10
申请号：US10195973
申请日：2002-07-16
申请人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
发明人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
IPC分类号： A61K314188
CPC分类号： C07D487/04 , C07F9/6561 , C07F9/657181 , Y02P20/582
摘要： A method for treating inflammatory and immune cell-mediated diseases by the administration of compounds of the formula I Exemplary are:
摘要翻译： 通过施用式I化合物治疗炎症和免疫细胞介导的疾病的方法是：
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公开(公告)号：US06492408B1
公开(公告)日：2002-12-10
申请号：US09604312
申请日：2000-06-27
申请人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
发明人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
IPC分类号： A61K314188
CPC分类号： C07D487/04 , C07F9/6561 , C07F9/657181 , Y02P20/582
摘要： Compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary are:
摘要翻译： 式I的化合物，其可用于治疗或预防炎性和免疫细胞介导的疾病。 示例是：
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16.发明授权Alpha-substituted N-sulfonyl gylcine amides antagonists of CCR10, compositions containing the same and methods for using them 有权CCR10的α-取代的N-磺酰基Gylcine酰胺拮抗剂，含有它们的组合物和使用它们的方法公开(公告)号：US08859814B2
公开(公告)日：2014-10-14
申请号：US12992766
申请日：2009-05-14
申请人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
发明人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
IPC分类号： C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07C241/00 , C07C241/02 , C07D211/00 , C07D211/68 , C07D211/80 , C07D213/02 , C07D217/00 , C07D209/04 , C07D231/00 , C07D277/60 , C07D277/62 , C07D211/22 , C07D403/12 , C07D217/06 , C07D295/185 , C07D513/04 , C07D487/04 , C07D211/70 , C07D401/14 , C07D209/08 , C07D211/62 , C07C311/19 , C07D211/16 , C07D409/12 , C07D413/12 , C07C311/44 , C07D407/12 , C07D401/12
CPC分类号： C07C311/19 , C07C311/44 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/62 , C07D211/70 , C07D217/06 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D513/04
摘要： Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
摘要翻译： 公开了式（I）的化合物。 其中R1，R2Ar和Cy如本文所定义，或其药学上可接受的盐。 还公开了式（I）化合物的药物组合物，制备式I化合物的方法和使用式（I）化合物治疗与CCR10活化相关的病症的方法。
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17.发明申请ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM 有权ALPHA取代的N-SULFONYL GYLCINE辅助CCR10的拮抗剂，含有它们的组合物和使用它们的方法公开(公告)号：US20110275612A1
公开(公告)日：2011-11-10
申请号：US12992766
申请日：2009-05-14
申请人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
发明人： Derek Cogan , Alexander Heim-Riether , Wang Mao , Craig Andrew Miller , Philip Dean Ramsden , Lana Louise Smith Keenan , Roger John Snow , Jiang-Ping Wu , Yu Yang
IPC分类号： A61K31/445 , C07D217/18 , C07D401/06 , C07D403/06 , C07D513/04 , C07D405/06 , C07C311/19 , C07D413/06 , C07D487/04 , C07D417/06 , A61K31/472 , A61K31/4545 , A61K31/454 , A61K31/4525 , A61K31/18 , C07D217/24 , A61K31/55 , A61K31/553 , A61K31/5513 , A61K31/4985 , A61P17/06 , A61P17/00 , A61P19/04 , A61P11/06 , C07D211/32
CPC分类号： C07C311/19 , C07C311/44 , C07D209/08 , C07D211/16 , C07D211/22 , C07D211/62 , C07D211/70 , C07D217/06 , C07D295/185 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D487/04 , C07D513/04
摘要： Disclosed is a compound of formula (I). Wherein R1, R2Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.
摘要翻译： 公开了式（I）的化合物。 其中R1，R2Ar和Cy如本文所定义，或其药学上可接受的盐。 还公开了式（I）化合物的药物组合物，制备式I化合物的方法和使用式（I）化合物治疗与CCR10活化相关的病症的方法。
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![Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2008/07/29/US07405225B2/abs.jpg.150x150.jpg)
18.发明授权Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US07405225B2
公开(公告)日：2008-07-29
申请号：US11206707
申请日：2005-08-18
申请人： Charles L. Cywin , Zhidong Chen , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu
发明人： Charles L. Cywin , Zhidong Chen , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US08946203B2
公开(公告)日：2015-02-03
申请号：US13785034
申请日：2013-03-05
申请人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
发明人： Asitha Abeywardane , Steven Richard Brunette , Michael J. Burke , Suresh R. Kapadia , Thomas Martin Kirrane , Matthew Russell Netherton , Hossein Razavi , Sonia Rodriguez , Anjan Saha , Robert Sibley , Lana Louise Smith-Keenan , Hidenori Takahashi , Michael Robert Turner , Jiang-Ping Wu , Erick Richard Roush Young , Qiang Zhang , Qing Zhang , Renee M. Zindell
IPC分类号： C07D519/00 , C07D491/04 , C07D487/08 , A61K31/357 , C07D491/052 , C07D405/10 , C07D295/096 , C07D295/155 , C07D513/04 , C07D405/14 , C07D319/20 , C07D405/12 , C07D487/10 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
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公开(公告)号：US20100190773A1
公开(公告)日：2010-07-29
申请号：US12727570
申请日：2010-03-19
申请人： Asitha ABEYWARDANE , Craig Andrew MILLER , Tina Marie MORWICK , Neil MOSS , Matthew Russell NETHERTON , Roger John SNOW , Ji WANG , Jiang-Ping WU , Zhaoming XIONG
发明人： Asitha ABEYWARDANE , Craig Andrew MILLER , Tina Marie MORWICK , Neil MOSS , Matthew Russell NETHERTON , Roger John SNOW , Ji WANG , Jiang-Ping WU , Zhaoming XIONG
IPC分类号： A61K31/55 , C07D471/04 , A61K31/437 , C07D401/12 , A61K31/4439 , C07D487/04 , A61P3/10 , A61P1/00 , A61P19/02 , A61P25/28 , A61P9/04 , A61P11/06
CPC分类号： C07D471/02
摘要： Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
摘要翻译： 杂环化合物及其类似物及其作为丝裂原活化蛋白激酶活化蛋白激酶-2（MAPKAP-k2）的抑制剂的用途，以及用于预防或治疗疾病或病症的方法，所述方法可以通过调节 MAPKAP-K2在受试者中的活性以及包括这些MAPKAP-K2抑制剂的药物组合物和试剂盒。
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