公开(公告)号：US20240309001A1

公开(公告)日：2024-09-19

申请号：US18675780

申请日：2024-05-28

Applicant: Incyte Corporation

Inventor： Shili Chen ,  Zhongjiang Jia ,  Pingli Liu ,  Lei Qiao ,  Yongzhong Wu ,  Jiacheng Zhou ,  Qun Li

IPC: C07D471/04 ,  A01M31/06 ,  C07D471/02 ,  C07F5/02

CPC classification number: C07D471/04 ,  A01M31/06 ,  C07D471/02 ,  C07F5/025 ,  C07B2200/13

Abstract: The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.

公开(公告)号：US20240279258A1

公开(公告)日：2024-08-22

申请号：US18594725

申请日：2024-03-04

Applicant: Forward Therapeutics, Inc.

Inventor： Toufike KANOUNI

IPC: C07F9/6561 ,  A61K9/08 ,  A61K9/48 ,  C07D471/02 ,  C07F9/6558 ,  C07F9/6584

CPC classification number: C07F9/6561 ,  A61K9/08 ,  A61K9/4825 ,  C07D471/02 ,  C07F9/65583 ,  C07F9/6584

Abstract: Provided herein are inhibitors of TNF-α, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the TNF-α inhibitory compounds for the treatment of diseases or disorders.

公开(公告)号：US09951028B2

公开(公告)日：2018-04-24

申请号：US14917191

申请日：2014-09-18

Applicant: REDAG CROP PROTECTION LTD

Inventor： Christopher Urch ,  William Thompson

IPC: C07D239/553 ,  A01N37/34 ,  A01N43/54 ,  A01N43/713 ,  C07D239/54 ,  C07D471/02 ,  C07D257/04 ,  C07D257/06 ,  C07D271/08 ,  A01N37/10 ,  A01N43/653 ,  A01N43/82 ,  A01N43/90

CPC classification number: C07D239/553 ,  A01N37/10 ,  A01N37/34 ,  A01N43/54 ,  A01N43/653 ,  A01N43/713 ,  A01N43/82 ,  A01N43/90 ,  C07D239/54 ,  C07D257/04 ,  C07D257/06 ,  C07D271/08 ,  C07D471/02

Abstract: The present invention relates to compounds which are of use in the field of agriculture as herbicides. The invention also relates to compositions comprising said compounds and methods of using said compounds.

公开(公告)号：US20170232113A1

公开(公告)日：2017-08-17

申请号：US15583492

申请日：2017-05-01

Applicant: Genentech, Inc.

Inventor： John A. Flygare ,  Thomas Pillow ,  Leanna Staben

IPC: A61K47/48 ,  C07K19/00

CPC classification number: C07D417/14 ,  A61K47/6803 ,  A61K47/6805 ,  A61K47/6851 ,  A61K47/6889 ,  C07D403/12 ,  C07D403/14 ,  C07D471/02

Abstract: This invention relates to quaternary amine linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.

公开(公告)号：US08138189B2

公开(公告)日：2012-03-20

申请号：US12727269

申请日：2010-03-19

Applicant: Daniel Hunziker ,  Chrisitan Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

Inventor： Daniel Hunziker ,  Chrisitan Lerner ,  Werner Mueller ,  Ulrike Obst Sander ,  Philippe Pflieger ,  Pius Waldmeier

IPC: A61K31/497

CPC classification number: C07D241/12 ,  C07D207/34 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D215/14 ,  C07D217/16 ,  C07D241/42 ,  C07D333/38 ,  C07D401/12 ,  C07D413/12 ,  C07D471/02

Abstract: The present invention relates to compounds of formula I wherein R.sup.1a to R.sup.1e and R.sup.2 to R.sup.5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Abstract translation: 本发明涉及式I化合物，其中R 1和R 2与R.sup.5的定义如说明书和权利要求书及其药学上可接受的盐。 该化合物是可用于治疗和/或预防糖尿病，血脂异常，肥胖，高血压，心血管疾病，肾上腺不平衡或抑郁症等疾病的糖皮质激素受体拮抗剂。

公开(公告)号：US07465726B2

公开(公告)日：2008-12-16

申请号：US11194158

申请日：2005-08-01

Applicant: Saleh Ahmed ,  Oscar Barba ,  Jason Bloxham ,  Graham Dawson ,  William Gattrell ,  John Kitchin ,  Neil Anthony Pegg ,  Imaad Saba ,  Shazia Sadiq ,  Colin Peter Sambrook Smith ,  Don Smyth ,  Amo G. Steinig ,  Robin Wilkes ,  Bijoy Panicker ,  Paula Tavares ,  Matthew Cox ,  An-Hu Li ,  Hanqing Dong ,  Lifu Ma ,  Kenneth (‘Ken’) Foreman ,  Qinghua (‘Felix’) Weng ,  Kathryn Stolz

Inventor： Saleh Ahmed ,  Oscar Barba ,  Jason Bloxham ,  Graham Dawson ,  William Gattrell ,  John Kitchin ,  Neil Anthony Pegg ,  Imaad Saba ,  Shazia Sadiq ,  Colin Peter Sambrook Smith ,  Don Smyth ,  Amo G. Steinig ,  Robin Wilkes ,  Bijoy Panicker ,  Paula Tavares ,  Matthew Cox ,  An-Hu Li ,  Hanqing Dong ,  Lifu Ma ,  Kenneth (‘Ken’) Foreman ,  Qinghua (‘Felix’) Weng ,  Kathryn Stolz

IPC: A61K31/437 ,  A61K31/496 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/5513 ,  A61K31/551 ,  C07D471/04 ,  C07D223/04 ,  C07D243/08 ,  C07D241/04 ,  C07D413/10 ,  C07D413/06 ,  C07D413/08 ,  C07D413/12 ,  C07D413/14 ,  C07D417/06 ,  C07D417/14 ,  A61K31/04 ,  A61K31/519 ,  C07D487/04

CPC classification number: C07D471/02 ,  C07D487/02 ,  C07D487/04

Abstract: Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.

Abstract translation: 由式（I）表示的化合物或其立体异构体或其药学上可接受的盐是Abl，Aurora-A，Blk，c-Raf，cSRC，Src，PRK2，FGFR3，Flt3，Lck，Mek1，PDK中的至少两种的抑制剂 -1，GSK3beta，EGFR，p70S6K，BMX，SGK，CaMKII，Tie-2，IGF-1R，Ron，Ret和KDR激酶，用于治疗和/或预防各种疾病和病症， 癌症。

公开(公告)号：US20080210858A1

公开(公告)日：2008-09-04

申请号：US12023468

申请日：2008-01-31

Applicant: Daniel W. Armstrong ,  Junmin Huang

Inventor： Daniel W. Armstrong ,  Junmin Huang

IPC: H01J49/26 ,  C07D403/10 ,  C07D207/04 ,  C07F9/28 ,  C07C211/43 ,  C07D243/04 ,  B01D15/08 ,  G01N30/18 ,  G01N30/02 ,  G01N30/96

CPC classification number: C07F9/5449 ,  B01J20/286 ,  B01J20/292 ,  C07C215/40 ,  C07C305/06 ,  C07C309/05 ,  C07D207/08 ,  C07D233/64 ,  C07D275/06 ,  C07D291/06 ,  C07D295/12 ,  C07D471/02 ,  Y02P20/542

Abstract: Polyionic liquid salts are provided comprising polycationic or polyanionic molecules. Further provided are solvents comprising one or more polyionic liquid salts, and the use of such polyionic liquid salts as stationary phases in gas chromatography, and as a reagent in electrospray ionization-mass spectrometry (ESI-MS).

Abstract translation: 提供了包含聚阳离子或聚阴离子分子的聚离子液体盐。 还提供了包含一种或多种聚离子液体盐的溶剂，以及在气相色谱法中作为固定相使用这种聚离子液体盐，以及作为电喷雾离子化 - 质谱法（ESI-MS）中的试剂。

公开(公告)号：US20070219196A1

公开(公告)日：2007-09-20

申请号：US10599159

申请日：2005-03-24

Applicant: Larry Krepski ,  Joseph Dellaria Jr. ,  Daniel Duffy ,  David Amos ,  Bernhard Zimmermann ,  William Moser

Inventor： Larry Krepski ,  Joseph Dellaria Jr. ,  Daniel Duffy ,  David Amos ,  Bernhard Zimmermann ,  William Moser

IPC: A61K31/4353 ,  A61K31/5377 ,  C07D413/14 ,  C07D471/02 ,  C07D471/12

CPC classification number: C07D471/04 ,  C07D413/14 ,  C07D471/02 ,  C07D471/12 ,  C07D471/14

Abstract: Imidazopyridine, imidazoquinoline, and imidazonaphthyridine compounds having an amide substituent at the 1-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 咪唑并吡啶，咪唑并喹啉和咪唑并吡啶化合物，其在1-位具有酰胺基取代基，含有化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗 公开了包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US07163947B2

公开(公告)日：2007-01-16

申请号：US10933658

申请日：2004-09-03

Applicant: George W. Griesgraber ,  Karl J. Manske

Inventor： George W. Griesgraber ,  Karl J. Manske

IPC: A01N43/42 ,  A61K31/44 ,  C07D491/00 ,  C07D498/00 ,  C07D513/00

CPC classification number: C07D471/02

Abstract: 1-Amino 1H-imidazoquinoline compounds, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 公开了1-氨基-1H-咪唑并喹啉化合物，含有这些化合物的药物组合物，中间体及其制备方法以及这些化合物作为免疫调节剂的用途，用于调节动物中的细胞因子生物合成和治疗包括病毒和肿瘤疾病在内的疾病。

公开(公告)号：US20060142298A1

公开(公告)日：2006-06-29

申请号：US11301046

申请日：2005-12-12

Applicant: John Kadow ,  Alicia Regueiro-Ren

Inventor： John Kadow ,  Alicia Regueiro-Ren

IPC: A61K31/496 ,  C07D471/02

CPC classification number: C07D471/04 ,  C07D471/02

Abstract: This disclosure provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the disclosure is concerned with new aminium salts of 1,2,3-triazoles which can be used as prodrugs to improve the solubility or pharmaceutical properties of 1,2,3-triazole containing compounds. More particularly, the present disclosure relates to compounds containing N-aminium-1,2,3-triazoles that are useful as antiviral agents and specifically for the treatment of HIV and AIDS.

Abstract translation: 本公开提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。 特别地，本公开涉及可用作前药以改善含1,2,3-三唑化合物的溶解度或药物性质的1,2,3-三唑的新的铵盐。 更具体地说，本公开内容涉及可用作抗病毒剂并特别用于治疗HIV和AIDS的N-氨基-1,2,3-三唑的化合物。