摘要:
The present invention relates to novel hepcidin antagonists, pharmaceutical compositions comprising them and the use thereof as medicaments for the use in the treatment of iron metabolism disorders, such as, in particular, iron deficiency diseases and anemias, in particular anemias in connection with chronic inflammatory diseases.
摘要:
Compounds of formula (I): or pharmaceutically acceptable salts and esters thereof, are useful for the treatment of obesity, type II diabetes and the metabolic syndrome.
摘要:
Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要:
Mercaptoamide compounds, represented by Formulas (IA), (IB), (IIA), and (IIB): or a pharmaceutically acceptable salt thereof, inhibit histone deacetylase enzyme and are useful for the treatment and/or prevention of various infections, cancerous diseases, and conditions.
摘要:
According to an aspect of the present invention, a cryostat includes two separate cooling means, one for reducing the temperature in a cooling chamber (2) and the other arranged to cool a freezing plate (8). In one embodiment, there may be a single cooling circuit, with e.g. a single reservoir of refrigerant, but with a separate compressor provided for each of the cooling means i.e. one compressor to control the temperature within the cooling chamber (2) and a separate compressor for the cooling circuit associated with the freezing plate (8). In accordance with another aspect of the present invention, the freezing plate (8) includes means for retaining some liquid on the surface of the freezing plate. In an embodiment, these means are provided by a lip (12). In a further aspect a friction generating means provides resistance to the movement of the microtome head, for example by providing a spring loaded collar on rotatable shaft. In a further aspect a cryostat is provided with a touch screen display.
摘要:
Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mek1, PDK-1, GSK3β, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-1R, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.
摘要:
Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C0-4alkyl, are useful in the treatment of cancer.