公开(公告)号：US20080041069A1

公开(公告)日：2008-02-21

申请号：US11575352

申请日：2005-09-16

申请人： David Vicar ,  Graham Dawson ,  Mark Barratt ,  John Cox

发明人： David Vicar ,  Graham Dawson ,  Mark Barratt ,  John Cox

IPC分类号： F25B19/00

CPC分类号： G01N1/42 ,  G01N1/06

摘要： According to an aspect of the present invention, a cryostat includes two separate cooling means, one for reducing the temperature in a cooling chamber (2) and the other arranged to cool a freezing plate (8). In one embodiment, there may be a single cooling circuit, with e.g. a single reservoir of refrigerant, but with a separate compressor provided for each of the cooling means i.e. one compressor to control the temperature within the cooling chamber (2) and a separate compressor for the cooling circuit associated with the freezing plate (8). In accordance with another aspect of the present invention, the freezing plate (8) includes means for retaining some liquid on the surface of the freezing plate. In an embodiment, these means are provided by a lip (12). In a further aspect a friction generating means provides resistance to the movement of the microtome head, for example by providing a spring loaded collar on rotatable shaft. In a further aspect a cryostat is provided with a touch screen display.

摘要翻译： 根据本发明的一个方面，低温恒温器包括两个单独的冷却装置，一个用于降低冷却室（2）中的温度，另一个用于冷却冷冻板（8）。 在一个实施例中，可以存在单个冷却回路。 单个制冷剂储存器，但是具有为每个冷却装置设置的单独的压缩机，即一个用于控制冷却室（2）内的温度的压缩机和用于与冷冻板（8）相关联的冷却回路的单独的压缩机。 根据本发明的另一方面，冷冻板（8）包括用于将一些液体保持在冷冻板的表面上的装置。 在一个实施例中，这些装置由唇缘（12）提供。 在另一方面，摩擦产生装置提供对切片机头的运动的阻力，例如通过在可旋转的轴上设置弹簧加载的环。 在另一方面，低温恒温器设置有触摸屏显示器。

公开(公告)号：US10264928B1

公开(公告)日：2019-04-23

申请号：US15933029

申请日：2018-03-22

申请人： John Cox

发明人： John Cox

IPC分类号： A47K10/22 ,  B65D25/10 ,  E03C1/308

摘要： A bathroom storage device for convenient concealed storage of a toilet plunger and visible storage of multiple vertically stacked rolls of toilet paper. The cup of the toilet plunger is concealed within a base unit having an open top from which the handle of the toilet plunger protrudes. A top member with a hollow vertical spindle is placed over the open top, thereby concealing the cup and handle of the toilet plunger within the base unit and hollow vertical spindle, respectively. Spaced vertical members about the periphery of the top member partially conceal the vertically stacked rolls of toilet paper while still enabling visual ascertainment of their number. The hollow vertical spindle may serve as a handle by which the top member and stacked rolls of toilet paper can be removed to gain access to the toilet plunger.

公开(公告)号：US08466265B2

公开(公告)日：2013-06-18

申请号：US12681050

申请日：2008-10-02

申请人： John Cox

发明人： John Cox

IPC分类号： C07K1/16 ,  C07K1/30 ,  C07K1/34

CPC分类号： C07K16/18 ,  C07K2317/10 ,  C07K2317/21

摘要： A method of preparing anti-b amyloid immunoglobulin involves treating human plasma anti-b amyloid immunoglobulin under alkaline conditions, such as at pH 10.25 to 11.75 using diethylamine HCl, to dissociate b amyloid protein therefrom. Typically, the anti-b amyloid immunoglobulin is present in human immunoglobulin preparations obtained from plasma or serum. Anti-b amyloid immunoglobulin prepared by the method is substantially free of b amyloid protein and has therapeutic activity in compositions and/or methods for treating a disease or condition associated with b amyloid plaques, such as Alzheimer's disease.

摘要翻译： 制备抗-B淀粉样蛋白免疫球蛋白的方法包括在碱性条件下，例如使用二乙胺HCl在pH10.25至11.75处理人血浆抗-B淀粉样蛋白免疫球蛋白，从而从其中解离淀粉样蛋白。 通常，抗-B淀粉样蛋白免疫球蛋白存在于从血浆或血清获得的人免疫球蛋白制剂中。 通过该方法制备的抗-B淀粉样蛋白免疫球蛋白基本上不含β-淀粉样蛋白，并且在用于治疗与淀粉样斑块（例如阿尔茨海默氏病）相关的疾病或病症的组合物和/或方法中具有治疗活性。

公开(公告)号：US20100047271A1

公开(公告)日：2010-02-25

申请号：US12612992

申请日：2009-11-05

申请人： Debbi Drane ,  John Cox ,  Michael Houghton ,  Xavier Pallard

发明人： Debbi Drane ,  John Cox ,  Michael Houghton ,  Xavier Pallard

IPC分类号： A61K39/29 ,  A61P31/12

CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/57 ,  C12N2770/24234

摘要： The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen, wherein the charged antigen is a polyprotein of Hepatitis C Virus (HCV), particularly the core protein of HCV, or a fragment thereof, or a fusion protein comprising the polyprotein or a fragment thereof. The complexes of the present invention are useful, inter alia, in vaccine compositions as therapeutic and/or prophylactic agents for facilitating the induction of immune responses, and in particular a cytotoxic T-lymphocyte response, in the treatment of a disease condition which results from an HCV infection.

摘要翻译： 本发明一般涉及包含带电荷的有机载体和带​​电荷的抗原的免疫原性复合物，更具体地，涉及带负电荷的有机载体和带​​正电荷的抗原，其中带电的抗原是丙型肝炎病毒（HCV）的多蛋白，特别是 HCV的核心蛋白或其片段，或包含该多聚蛋白或其片段的融合蛋白。 本发明的复合物尤其可用于疫苗组合物中，作为促进免疫应答诱导的治疗和/或预防剂，特别是细胞毒性T淋巴细胞应答，用于治疗由 HCV感染。

公开(公告)号：US20050253430A1

公开(公告)日：2005-11-17

申请号：US11057360

申请日：2005-02-14

申请人： Larry George ,  John Cox

发明人： Larry George ,  John Cox

IPC分类号： A47C1/124 ,  A47C13/00 ,  A47C15/00

CPC分类号： A47C13/005 ,  A47C1/124

摘要： A seating system includes several individual seating units that are coupled together with at least one bracket, where the bracket extends between two seating units.

摘要翻译： 座椅系统包括几个单独的座位单元，其与至少一个支架联接在一起，支架在两个座位单元之间延伸。

公开(公告)号：US20050012970A1

公开(公告)日：2005-01-20

申请号：US10915991

申请日：2004-08-10

申请人： John Cox ,  Christopher Christuk ,  Jeffrey Gagnon

发明人： John Cox ,  Christopher Christuk ,  Jeffrey Gagnon

IPC分类号： B44F1/10 ,  B65D55/02 ,  B65D75/00 ,  G03H1/02 ,  G03H1/00

CPC分类号： G03H1/028 ,  B32B37/12 ,  B32B2310/0887 ,  B44F1/10 ,  B65D55/026 ,  B65D75/002 ,  B65D2203/00 ,  G03H1/0011 ,  G03H1/0244 ,  G03H2001/185 ,  G03H2227/04 ,  G03H2250/12 ,  Y10S428/913

摘要： A holographic shrink wrap element containing a shrink wrap film and a layer on the shrink wrap film, wherein the layer contains a holographic image. A process for preparing a holographic shrink wrap element includes providing, in the following order, a holographic polymer film having a holographic surface, a layer on the holographic surface and a shrink wrap film, and removing the holographic polymer film, leaving the holographic image on the layer.

摘要翻译： 包含收缩保鲜膜和收缩包装膜上的层的全息收缩包装元件，其中该层包含全息图像。 一种制备全息收缩包膜元件的方法包括以下列顺序提供具有全息表面，全息表面上的层和收缩保鲜膜的全息聚合物膜，并且除去全息聚合物膜，使全息图像保持在 层。

公开(公告)号：US4813182A

公开(公告)日：1989-03-21

申请号：US52258

申请日：1987-05-20

申请人： Kurt Daniels ,  John D. Williams ,  Percy W. Wise ,  Ian Jackson ,  John Cox

发明人： Kurt Daniels ,  John D. Williams ,  Percy W. Wise ,  Ian Jackson ,  John Cox

IPC分类号： E05B65/00 ,  E06B11/02 ,  E06B3/00

CPC分类号： A01K1/0017 ,  E05B65/0007 ,  E06B11/02 ,  Y10T292/1049 ,  Y10T403/4602 ,  Y10T403/4697

摘要： In a gate, a stile (20) and rail (21) abut side face to end face and are held together by a bolt passing at right angles through the end face to pull against a plate (25) located in a slot (26). Straps (34,41), see FIGS. 11 and 13, are used to reinforce the hanging and shutting stiles (20,20A) and to carry hanging and latching parts. A latching mechanism, see FIGS. 13 to 16, includes a latching bar (43) that is pivotally connected to the shutting stile (20) towards its middle by a flange (44). A leaf spring (45) urges the bar (43) into a latching position at which, when the gate is shut, the bar (43) is caught behind upper and lower retainers (46) mounted on a shutting gatepost (48). By pulling on a handle (50), the bar (43) can be rocked free of the retainers (46) to permit the gate to be opened. Connector plates ( 31) having sharp tongs are used, see FIGS. 9 and 10, with bolts to connect reinforcing struts (30) to the upper and lower rails (21,21A). Upper and lower hinge brackets for mounting on a hanging gatepost are also provided, see FIGS. 17 to 23.

公开(公告)号：US20120325509A1

公开(公告)日：2012-12-27

申请号：US13494325

申请日：2012-06-12

申请人： Daniel Puzio ,  Robert J. Opsitos ,  Robert G. Kusmierski ,  Robert S. Gehret ,  John Cox ,  Craig A. Schell ,  Michael Haupt ,  Joseph Kelleher

发明人： Daniel Puzio ,  Robert J. Opsitos ,  Robert G. Kusmierski ,  Robert S. Gehret ,  John Cox ,  Craig A. Schell ,  Michael Haupt ,  Joseph Kelleher

IPC分类号： B25B21/02 ,  B25B23/00

CPC分类号： B25B21/02 ,  B25B23/0035

摘要： An impact wrench, includes a housing including a handle. A rotating anvil is supported by the housing and includes a polygonal head adapted for receiving a socket thereon. A socket retention device is mounted to the polygonal head of the rotating anvil for securing a socket to the polygonal head. A socket release mechanism includes an actuator mounted to the housing and operable to disengage the socket retention device from the socket to allow the socket to be removed from the anvil.

摘要翻译： 一种冲击扳手，包括一个包括把手的外壳。 旋转砧由壳体支撑并且包括一个多边形头部，用于在其上接收一个插座。 插座保持装置安装到旋转砧座的多边形头部，用于将插座固定到多边形头部。 插座释放机构包括安装到壳体并且可操作以将插座保持装置与插座脱开的致动器，以允许插座从砧座移除。

公开(公告)号：US20120283756A1

公开(公告)日：2012-11-08

申请号：US13479991

申请日：2012-05-24

申请人： Scott Moonly ,  John Cox ,  Richard C. Ewers

发明人： Scott Moonly ,  John Cox ,  Richard C. Ewers

IPC分类号： A61B17/00 ,  A61B17/03

CPC分类号： A61B17/0401 ,  A61B17/0487 ,  A61B2017/003 ,  A61B2017/00349 ,  A61B2017/00818 ,  A61B2017/0409 ,  A61B2017/0417

摘要： Devices and methods for endolumenally manipulating stomach fundus tissue alter the function of nearby nerves. The altered function of the nerves interacts with the cardiopulmonary system to cause a substantially permanent reduction in blood pressure. The altered nerve function may also treat heart disease as well. This application also relates to devices and methods for endolumenally manipulating stomach tissue to alter hormone production from cells associated with stomach tissue, providing a therapeutic effect in treating hypertension and heart disease, not conventionally associated with the stomach.

摘要翻译： 腔内操作胃底组织的装置和方法改变了附近神经的功能。 神经的改变功能与心肺系统相互作用，导致血压基本上永久性降低。 改变的神经功能也可以治疗心脏病。 本申请还涉及用于腔内操作胃组织以改变与胃组织相关的细胞的激素产生的装置和方法，在治疗高血压和心脏病方面提供治疗效果，而不是常规地与胃相关。

公开(公告)号：US20090216273A1

公开(公告)日：2009-08-27

申请号：US12388959

申请日：2009-02-19

申请人： John Cox

发明人： John Cox

IPC分类号： A61B17/70 ,  A61B17/88

CPC分类号： A61B17/1757 ,  A61B17/1604 ,  A61B17/1611 ,  A61B17/1615 ,  A61B17/1631 ,  A61B17/1671 ,  A61B17/7064 ,  A61B17/8665 ,  A61B17/8695

摘要： The present disclosure relates to a curved facet joint fixation assembly and an associated implantation tool and method. The curved facet joint fixation assembly includes an elongated curved shaft adapted to conform to various spinal morphologies. The implantation tool includes a bone fastening device with an angled lower end portion and a removable drive for cutting a hole and for driving the curved facet joint fixation assembly through the hole.

摘要翻译： 本发明涉及一种弯曲小关节固定组件和相关联的植入工具和方法。 曲面小关节固定组件包括适于符合各种脊柱形态的细长弯曲轴。 植入工具包括具有成角度的下端部分的骨固定装置和用于切割孔并用于通过孔驱动弯曲小面关节固定组件的可移除驱动器。