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公开(公告)号：US08299123B2
公开(公告)日：2012-10-30
申请号：US12738087
申请日：2008-10-14
申请人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
发明人： Kaka Dey , Donghong Amy Gao , Daniel R. Goldberg , Alexander Heim-Riether , John Edward Mangette , Ingo Andreas Mugge , Roger John Snow , Alan David Swinamer , Jiang-Ping Wu , Zhaoming Xiong , Yu Yang
IPC分类号： A61K31/195 , C07C229/00
CPC分类号： C07D249/06 , C07C235/60 , C07C235/62 , C07C2601/02 , C07D239/26 , C07D257/04
摘要： The invention relates to a compound of formula (I): or a tautomer thereof or a pharmaceutically acceptable salt thereof, wherein R1 to R11, W, X, Y, Z, and n are as defined herein. The invention also relates to methods of using the compounds of formula (I) and compositions thereof to treat various diseases and disorders in a patient. The invention also relates to processes for preparing the compounds of formula (I) and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物或其互变异构体或其药学上可接受的盐，其中R 1至R 11，W，X，Y，Z和n如本文所定义。 本发明还涉及使用式（I）化合物及其组合物来治疗患者的各种疾病和病症的方法。 本发明还涉及制备式（I）化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US07550494B2
公开(公告)日：2009-06-23
申请号：US10672412
申请日：2003-09-25
申请人： Jiang-Ping Wu , Terence Alfred Kelly , Rene M. Lemieux , Daniel R. Goldberg , Jonathan Emillian Emeigh , Ronald John Sorcek
发明人： Jiang-Ping Wu , Terence Alfred Kelly , Rene M. Lemieux , Daniel R. Goldberg , Jonathan Emillian Emeigh , Ronald John Sorcek
IPC分类号： A61K31/418 , C07D403/00 , D07D239/00
CPC分类号： C07D487/04 , C07F9/6561 , C07F9/657181 , Y02P20/582
摘要： Compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary are:
摘要翻译： 可用于治疗或预防炎症和免疫细胞介导的疾病的式I化合物。 示例是：
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公开(公告)号：US20060276496A1
公开(公告)日：2006-12-07
申请号：US11276933
申请日：2006-03-17
申请人： Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
发明人： Daniel Goldberg , Asitha Abeywardane , Craig Miller , Tina Morwick , Matthew Netherton , Roger Snow , Ji Wang , Jiang-Ping Wu , Zhaoming Xiong
IPC分类号： A61K31/4745 , A61K31/403 , C07D471/02
CPC分类号： C07D471/02
摘要： Heterocyclic compounds and analogues thereof and their use as inhibitors of Mitogen-Activated Protein Kinase-Activated Protein kinase-2 (MAPKAP-k2), and also to a method for preventing or treating a disease or disorder that can be treated or prevented by modulating the activity of MAPKAP-K2 in a subject and to pharmaceutical compositions and kits that include these MAPKAP-K2 inhibitors.
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公开(公告)号：US20060046986A1
公开(公告)日：2006-03-02
申请号：US11209234
申请日：2005-08-23
申请人： Donghong Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
发明人： Donghong Gao , Neil Moss , Ji Wang , Jiang-Ping Wu , Lifen Wu , Zhaoming Xiong
IPC分类号： A61K31/538 , A61K31/5377 , A61K31/52 , A61K31/519 , A61K31/501 , A61K31/496 , A61K31/4439
CPC分类号： C07D487/04 , C07D209/10 , C07D209/42 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D487/08
摘要： Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
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![Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/12/13/US06974870B2/abs.jpg.150x150.jpg)
公开(公告)号：US06974870B2
公开(公告)日：2005-12-13
申请号：US10730172
申请日：2003-12-06
申请人： Charles L. Cywin , Can Mao , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Erick Young , Darren DiSalvo , John Ginn , Pier Cirillo
发明人： Charles L. Cywin , Can Mao , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Erick Young , Darren DiSalvo , John Ginn , Pier Cirillo
IPC分类号： A61K31/38 , A61K31/435 , C07D495/04 , A61K31/4365 , A61K31/497 , A61K31/5377
CPC分类号： A61K31/38 , A61K31/435 , C07D495/04
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
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6.再颁专利Phenylpyrrolidines, phenylimidazolidines,3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease 有权苯基吡咯烷酮，苯基咪唑烷，3-苯基-1,3-恶唑烷和3-苯基-1,3-噻唑烷及其在治疗炎性疾病中的应用公开(公告)号：USRE38132E1
公开(公告)日：2003-06-03
申请号：US10167732
申请日：2002-06-12
IPC分类号： A61K314439
CPC分类号： C07D207/408 , C07D207/40 , C07D231/12 , C07D233/56 , C07D233/74 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/84 , C07D233/86 , C07D249/08 , C07D263/44 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07F9/59 , C07F9/6506 , C07F9/65583
摘要： A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of the following structural formulas:
摘要翻译： 通过给予某些新颖且已知的小分子来治疗或预防炎症和免疫细胞介导的疾病的方法。 新化合物的实例是下列结构式的化合物：
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公开(公告)号：US06365615B1
公开(公告)日：2002-04-02
申请号：US09605675
申请日：2000-06-28
IPC分类号： A61K31415
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 2-(3,5-Dichlorophenyl)-7-(R*)-phenyl-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; 2-(3,5-Dichlorophenyl)-7a-(R*)-methyl-7-(R*)-phenyl-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; and, 7-(R*)-(4-Bromophenyl)-2-(3,5-dichlorophenyl)-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione.
摘要翻译： 新颖的式I化合物，其可用于治疗或预防炎性和免疫细胞介导的疾病。 示例性化合物是：2-（3,5-二氯苯基）-7-（R *） - 苯基-7a-（R *） - 四氢吡咯并[1,2-c]咪唑-1,3-二酮; 2- ，5-二氯苯基）-7a-（R *） - 甲基-7-（R *） - 苯基 - 四氢吡咯并[1,2-c]咪唑-1,3-二酮; 和7-（R *） - （4-溴苯基）-2-（3,5-二氯苯基）-7a-（R *） - 四氢吡咯并[1,2-c]咪唑-1,3-二酮。
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8.发明授权Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease 有权苯基吡咯烷酮，苯基咪唑烷，3-苯基-1,3-恶唑烷和3-苯基-1,3-噻唑烷及其在治疗炎性疾病中的应用公开(公告)号：US06355664B1
公开(公告)日：2002-03-12
申请号：US09375010
申请日：1999-08-16
IPC分类号： A61K314439
CPC分类号： C07D207/408 , C07D207/40 , C07D231/12 , C07D233/56 , C07D233/74 , C07D233/76 , C07D233/78 , C07D233/80 , C07D233/84 , C07D233/86 , C07D249/08 , C07D263/44 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06 , C07D405/06 , C07D405/10 , C07D405/12 , C07D409/06 , C07F9/59 , C07F9/6506 , C07F9/65583
摘要： A method treating or preventing inflammatory and immune cell-mediated diseases by the administration of certain novel and known small molecules. Exemplary of the novel compounds are those of the following structural formulas:
摘要翻译： 通过给予某些新颖且已知的小分子来治疗或预防炎症和免疫细胞介导的疾病的方法。 新化合物的实例是下列结构式的化合物：
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公开(公告)号：US20130244996A1
公开(公告)日：2013-09-19
申请号：US13785034
申请日：2013-03-05
申请人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
发明人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael J. BURKE , Suresh R. KAPADIA , Thomas Martin KIRRANE , Matthew Russell NETHERTON , Hossein RAZAVI , Sonia RODRIGUEZ , Anjan SAHA , Robert SIBLEY , Lana Louise SMITH-KEENAN , Hidenori TAKAHASHI , Michael Robert TURNER , Jiang-Ping WU , Erick Richard Roush YOUNG , Qiang ZHANG , Qing ZHANG , Renee M. ZINDELL
IPC分类号： C07D491/052 , C07D513/04 , C07D295/155 , C07D405/10 , C07D295/096
CPC分类号： C07D491/052 , A61K31/357 , C07D295/096 , C07D295/155 , C07D319/20 , C07D405/10 , C07D405/12 , C07D405/14 , C07D413/10 , C07D417/10 , C07D417/14 , C07D471/10 , C07D487/04 , C07D487/08 , C07D487/10 , C07D491/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): wherein R1 to R3, A, X and n are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorder. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译： 本发明涉及式（I）的化合物：其中R1至R3，A，X和n如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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10.发明授权1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease 有权可用于治疗炎性疾病的1-苯基吡咯烷-2-酮和1-硫杂环戊二烯和1-（4-吡啶基）吡咯烷-2-酮和硫杂公开(公告)号：US06414153B1
公开(公告)日：2002-07-02
申请号：US09605584
申请日：2000-06-28
IPC分类号： C07D47102
CPC分类号： C07D471/04 , C07D209/34
摘要： Novel compounds of the formula I: which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-indol-2-one; 3-benzyl-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-hydroxy-3-methyl-1,3-dihydroindol-2-one; and, 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-fluoro-1,3-dihydroindol-2-one.
摘要翻译： 式I的新型化合物：其可用于治疗或预防炎性和免疫细胞介导的疾病。 示例性化合物是：3-（4-溴苄基）-1-（3,5-二氯苯基）-1,3-二氢吲哚-2-酮; 3-（4-溴苄基）-1-（3,5-二氯苯基） 3-甲基-1,3-二氢 - 吲哚-2-酮; 3-苄基-1-（3,5-二氯苯基）-3-甲基-1,3-二氢吲哚-2-酮; 3-（4-溴苄基 ）-1-（3,5-二氯苯基）-4-羟基-3-甲基-1,3-二氢吲哚-2-酮; 和3-（4-溴苄基）-1-（3,5-二氯苯基）-5-氟-1,3-二氢吲哚-2-酮。
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