-
1.发明授权1-phenylpydrrolidin-2-ones and -thiones and 1-(4-pyridyl)pydrrolidin-2-ones and -thiones which are useful in the treatment of inflammatory disease 有权可用于治疗炎性疾病的1-苯基吡咯烷-2-酮和1-硫杂环戊二烯和1-（4-吡啶基）吡咯烷-2-酮和硫杂公开(公告)号：US06414153B1
公开(公告)日：2002-07-02
申请号：US09605584
申请日：2000-06-28
IPC分类号： C07D47102
CPC分类号： C07D471/04 , C07D209/34
摘要： Novel compounds of the formula I: which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydro-indol-2-one; 3-benzyl-1-(3,5-dichlorophenyl)-3-methyl-1,3-dihydroindol-2-one; 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-4-hydroxy-3-methyl-1,3-dihydroindol-2-one; and, 3-(4-bromobenzyl)-1-(3,5-dichlorophenyl)-5-fluoro-1,3-dihydroindol-2-one.
摘要翻译： 式I的新型化合物：其可用于治疗或预防炎性和免疫细胞介导的疾病。 示例性化合物是：3-（4-溴苄基）-1-（3,5-二氯苯基）-1,3-二氢吲哚-2-酮; 3-（4-溴苄基）-1-（3,5-二氯苯基） 3-甲基-1,3-二氢 - 吲哚-2-酮; 3-苄基-1-（3,5-二氯苯基）-3-甲基-1,3-二氢吲哚-2-酮; 3-（4-溴苄基 ）-1-（3,5-二氯苯基）-4-羟基-3-甲基-1,3-二氢吲哚-2-酮; 和3-（4-溴苄基）-1-（3,5-二氯苯基）-5-氟-1,3-二氢吲哚-2-酮。
-
公开(公告)号：US06365615B1
公开(公告)日：2002-04-02
申请号：US09605675
申请日：2000-06-28
IPC分类号： A61K31415
CPC分类号： C07D471/04 , C07D487/04
摘要： Novel compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary compounds are: 2-(3,5-Dichlorophenyl)-7-(R*)-phenyl-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; 2-(3,5-Dichlorophenyl)-7a-(R*)-methyl-7-(R*)-phenyl-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione; and, 7-(R*)-(4-Bromophenyl)-2-(3,5-dichlorophenyl)-7a-(R*)-tetrahydropyrrolo[1,2-c]imidazole-1,3-dione.
摘要翻译： 新颖的式I化合物，其可用于治疗或预防炎性和免疫细胞介导的疾病。 示例性化合物是：2-（3,5-二氯苯基）-7-（R *） - 苯基-7a-（R *） - 四氢吡咯并[1,2-c]咪唑-1,3-二酮; 2- ，5-二氯苯基）-7a-（R *） - 甲基-7-（R *） - 苯基 - 四氢吡咯并[1,2-c]咪唑-1,3-二酮; 和7-（R *） - （4-溴苯基）-2-（3,5-二氯苯基）-7a-（R *） - 四氢吡咯并[1,2-c]咪唑-1,3-二酮。
-
3.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US07795272B2
公开(公告)日：2010-09-14
申请号：US11072797
申请日：2005-03-04
IPC分类号： A61K31/4704 , C07D453/02
CPC分类号： C07D471/04 , C07D215/14 , C07D311/58 , C07D405/06
摘要： Compounds of Formula (IA) and Formula (IB) where in R1 stands for the following group (the dashed line indicates the point of attachment) and R2, R3, R4, R5, R6, Y, Z, X1 and X2 are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（IA）和式（IB）的化合物，其中R1代表下列基团（虚线表示连接点），R2，R3，R4，R5，R6，Y，Z，X1和X2如上所定义 式（IA）和式（IB）的互变异构体，前体药物，溶剂化物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
-
4.发明申请Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US20060154925A1
公开(公告)日：2006-07-13
申请号：US11305362
申请日：2005-12-16
申请人： Daniel Kuzmich , Darren DiSalvo , John Regan , David Thomson
发明人： Daniel Kuzmich , Darren DiSalvo , John Regan , David Thomson
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/4709
CPC分类号： C07D471/04 , C07D209/08 , C07D209/16 , C07D209/86 , C07D215/06 , C07D215/233 , C07D231/56 , C07D235/14 , C07D307/79 , C07D333/58 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 式（I）的化合物，其中R 1，R 2，R 3，R 4，R 4， R 5，R 6和R 7如本文所定义，或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
-
公开(公告)号：US06489328B2
公开(公告)日：2002-12-03
申请号：US09921510
申请日：2001-08-02
申请人： Roger John Snow , Donghong A. Gao , Daniel R. Goldberg , Abdelhakim Hammach , Daniel Kuzmich , Tina Marie Morwick , Neil Moss , Anthony S. Prokopowicz, III , Robert D. Selliah , Hidenori Takahashi
发明人： Roger John Snow , Donghong A. Gao , Daniel R. Goldberg , Abdelhakim Hammach , Daniel Kuzmich , Tina Marie Morwick , Neil Moss , Anthony S. Prokopowicz, III , Robert D. Selliah , Hidenori Takahashi
IPC分类号： C07D48704
CPC分类号： C07D487/04 , A61K31/517
摘要： Disclosed are novel compounds of formula (I): wherein Ar1, X, Y, P, Q and Het are defined herein, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are pharmaceutical compositions comprising these compounds, processes for preparing these compounds and novel intermediate compounds useful in these processes.
摘要翻译： 公开了式（I）的新化合物：其中Ar1，X，Y，P，Q和Het在本文中定义，其可用作某些蛋白酪氨酸激酶的抑制剂，因此可用于治疗由不适当的细胞增殖引起的疾病， 包括自身免疫性疾病，慢性炎症性疾病，过敏性疾病，移植排斥和癌症，以及由脑缺血引起的病症，例如中风。 还公开了包含这些化合物的药物组合物，制备这些化合物的方法和用于这些方法的新型中间体化合物。
-
6.发明授权Methods and compositions for controlling intraocular pressure with transition metal complexes 失效用过渡金属络合物控制眼内压的方法和组合物
公开(公告)号：US5356932A
公开(公告)日：1994-10-18
申请号：US104242
申请日：1993-08-09
申请人： Hans R. Moll , Mark T. DuPriest , Daniel Kuzmich
发明人： Hans R. Moll , Mark T. DuPriest , Daniel Kuzmich
IPC分类号： A61K31/195 , A61K31/22 , A61K31/295
CPC分类号： A61K31/195 , A61K31/22 , Y10S514/913
摘要： Compositions and methods for controlling intraocular pressure using transition metal complexes are disclosed. Topical ophthalmic and systemic administration of the transition metal complexes is disclosed.
摘要翻译： 公开了使用过渡金属络合物控制眼压的组合物和方法。 披露了过渡金属络合物的局部眼科和全身给药。
-
公开(公告)号：US5151544A
公开(公告)日：1992-09-29
申请号：US530766
申请日：1990-05-25
IPC分类号： C07C229/50 , C07C275/26 , C07D235/02
CPC分类号： C07D235/02 , C07C229/50 , C07C275/26 , C07C2103/18
摘要： Disclosed is a process for the synthesis of enantiomerically pure R and S isomers of 2,7-difluoro-4-methoxyspiro[9H-fluorene-9,4-imidazolidene]-2',5'-dione from 2,7-difluoro-4-methoxyfluorenone. Intermediate amino acid esters and urea esters and their preparation are also described.
摘要翻译： 公开了从2,7-二氟-2-甲基苯酚合成2,7-二氟-4-甲氧基螺[9H-咪唑烷] -2'，5'-二酮的对映体纯R和S异构体的方法， 4-甲氧基芴酮。 还描述了中间体氨基酸酯和脲酯及其制备方法。
-
公开(公告)号：US20110034512A1
公开(公告)日：2011-02-10
申请号：US12937378
申请日：2009-04-23
申请人： Darren Disalvo , Daniel Kuzmich , Can Mao , Hossein Razavi , Christopher Sarko , Alan David Swinamer , David Smith Thomson , Qiang Zhang
发明人： Darren Disalvo , Daniel Kuzmich , Can Mao , Hossein Razavi , Christopher Sarko , Alan David Swinamer , David Smith Thomson , Qiang Zhang
IPC分类号： A61K31/416 , C07D231/56 , A61K31/4439 , C07D401/02 , A61K31/454 , A61P1/00 , A61P19/02 , A61P11/06 , A61P13/12 , A61P25/28 , A61P3/10 , A61P37/00
CPC分类号： C07D231/56 , C07D401/12
摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
-
9.发明申请Glucocorticoid Mimetics, Methods of Making Them, Pharmaceutical Compositions and Uses Thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US20100197678A1
公开(公告)日：2010-08-05
申请号：US12517874
申请日：2007-11-29
IPC分类号： A61K31/5383 , C07D471/04 , A61K31/437 , C07D487/04 , A61K31/519 , C07D498/04 , A61P29/00
CPC分类号： C07D417/06 , C07D231/56 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D407/14 , C07D409/06 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00
摘要： Compounds of Formula (IA) wherein R1, R2, R3, A, B, C, D, E, G, X, Y, and Z are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R1，R2，R3，A，B，C，D，E，G，X，Y和Z如本文所定义的式（IA）化合物或其互变异构体，前药，溶剂合物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
-
10.发明授权Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof 有权糖皮质激素模拟物，其制备方法，药物组合物及其用途公开(公告)号：US07741361B2
公开(公告)日：2010-06-22
申请号：US11305362
申请日：2005-12-16
IPC分类号： A61K31/404 , A61K31/18 , C07D209/04 , C07C307/02
CPC分类号： C07D471/04 , C07D209/08 , C07D209/16 , C07D209/86 , C07D215/06 , C07D215/233 , C07D231/56 , C07D235/14 , C07D307/79 , C07D333/58 , C07D401/04 , C07D403/04 , C07D413/04
摘要： Compounds of Formula (I) wherein R1, R2, R3, R4, R5, R6, and R7 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如本文所定义的式（I）化合物或其互变异构体，前药，溶剂化物或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。
-
-
-
-
-
-
-
-
-
搜索结果
47 条记录 (耗时 0.044 秒)
