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公开(公告)号：US20120165322A1
公开(公告)日：2012-06-28
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A61K31/472 , A61K31/4725 , C07D471/04 , C07D487/04 , A61K31/4985 , C07D417/14 , C07D417/12 , A61K31/5415 , A61K31/541 , C07D413/12 , C07D413/14 , C07D401/12 , A61K31/506 , C07D405/12 , A61K31/5377 , A61K31/538 , A61K31/497 , A61K31/4439 , C07D513/04 , A61K31/428 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P15/10 , A61P13/12 , A61P11/06 , A61P27/06 , A61P35/00 , A61P25/28 , A61P29/00 , A61P17/06 , A61P1/00 , A61K31/437 , C07D217/02
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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![Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2009/09/22/US07592353B2/abs.jpg.150x150.jpg)
2.发明授权Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US07592353B2
公开(公告)日：2009-09-22
申请号：US11755956
申请日：2007-05-31
IPC分类号： A61K31/4743 , C07D498/02
CPC分类号： C07D495/04
摘要： Disclosed are compounds of formula (I): wherein R1 and R4 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases, cardiovascular disease and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 4在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂。 因此，该化合物可用于治疗IKK介导的疾病，包括自身免疫性疾病，炎性疾病，心血管疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US08697911B2
公开(公告)日：2014-04-15
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A01N37/18 , A61K31/165 , C07C239/00 , C07C279/16 , C07D473/00 , C07D417/00 , C07C45/78 , C07C271/06 , C07D271/12 , C07D413/00 , C07D271/00 , C07D285/02 , C07D285/04 , C07D498/00 , C07D513/00 , C07D277/82 , C07D263/60 , C07D249/04 , C07D249/08 , C07D233/02 , C07D231/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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![Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/11/15/US06964956B2/abs.jpg.150x150.jpg)
4.发明授权Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US06964956B2
公开(公告)日：2005-11-15
申请号：US10453175
申请日：2003-06-03
申请人： Charles L. Cywin , Zhidong Chen , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
发明人： Charles L. Cywin , Zhidong Chen , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
IPC分类号： A61K31/38 , A61K31/435 , A61K31/4365 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P39/00 , A61P43/00 , C07B61/00 , C07D495/04 , C07D519/00 , A61K31/551
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US08952004B2
公开(公告)日：2015-02-10
申请号：US13520234
申请日：2011-01-05
申请人： John David Ginn , Ronald John Sorcek , Michael Robert Turner , Di Wu , Frank Wu
发明人： John David Ginn , Ronald John Sorcek , Michael Robert Turner , Di Wu , Frank Wu
IPC分类号： A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D498/08 , C07D407/14 , C07D211/26 , C07D211/32 , C07D213/74 , C07D401/06 , C07D401/12 , C07D417/06 , C07D417/12 , C07D487/06 , C07D497/04 , A61K31/553 , C07D413/06
CPC分类号： C07D407/14 , C07D211/26 , C07D211/32 , C07D213/74 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/06 , C07D417/12 , C07D471/04 , C07D487/06 , C07D497/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R3, A, B, X, and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R1至R3，A，B，X和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20140031339A1
公开(公告)日：2014-01-30
申请号：US13942988
申请日：2013-07-16
申请人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
发明人： Asitha ABEYWARDANE , Steven Richard BRUNETTE , Michael Jason BURKE , Thomas Martin KIRRANE, JR. , Chuk Chui MAN , Daniel Richard MARSHALL , Anil Kumar PADYANA , Hossein RAZAVI , Robert SIBLEY , Lana Louise SMITH KEENAN , Roger John SNOW , Ronald John SORCEK , Hidenori TAKAHASHI , Steven John TAYLOR , Michael Robert TURNER , Erick Richard Roush YOUNG , Qiang ZHANG , Yunlong ZHANG , Renee M. ZINDELL
IPC分类号： C07D401/14 , C07D413/14 , C07D487/04 , C07D498/04 , C07D497/08 , A61K31/5377 , A61K31/55 , A61K31/549 , A61K31/496 , A61K31/4545 , A61K31/454 , C07D405/12 , A61K31/551
CPC分类号： C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中A1，A2，L1和B如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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公开(公告)号：US08450317B2
公开(公告)日：2013-05-28
申请号：US12768268
申请日：2010-04-27
申请人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
发明人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
IPC分类号： C07D239/34 , C07D239/42 , A61K31/506
CPC分类号： C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R5, A, B, D and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1至R 5，A，B，D和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US06689804B2
公开(公告)日：2004-02-10
申请号：US10195973
申请日：2002-07-16
申请人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
发明人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
IPC分类号： A61K314188
CPC分类号： C07D487/04 , C07F9/6561 , C07F9/657181 , Y02P20/582
摘要： A method for treating inflammatory and immune cell-mediated diseases by the administration of compounds of the formula I Exemplary are:
摘要翻译： 通过施用式I化合物治疗炎症和免疫细胞介导的疾病的方法是：
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公开(公告)号：US06492408B1
公开(公告)日：2002-12-10
申请号：US09604312
申请日：2000-06-27
申请人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
发明人： Jiang-Ping Wu , Terence Alfred Kelly , Rene Lemieux , Daniel R. Goldberg , Jonathan Emilian Emeigh , Ronald John Sorcek
IPC分类号： A61K314188
CPC分类号： C07D487/04 , C07F9/6561 , C07F9/657181 , Y02P20/582
摘要： Compounds of the formula I which are useful for treating or preventing inflammatory and immune cell-mediated diseases. Exemplary are:
摘要翻译： 式I的化合物，其可用于治疗或预防炎性和免疫细胞介导的疾病。 示例是：
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公开(公告)号：US09403830B2
公开(公告)日：2016-08-02
申请号：US13942988
申请日：2013-07-16
申请人： Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
发明人： Asitha Abeywardane , Steven Richard Brunette , Michael Jason Burke , Thomas Martin Kirrane, Jr. , Chuk Chui Man , Daniel Richard Marshall , Anil Kumar Padyana , Hossein Razavi , Robert Sibley , Lana Louise Smith Keenan , Roger John Snow , Ronald John Sorcek , Hidenori Takahashi , Steven John Taylor , Michael Robert Turner , Erick Richard Roush Young , Qiang Zhang , Yunlong Zhang , Renee M. Zindell
IPC分类号： C07D487/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D405/12 , C07D497/08 , C07D498/04
CPC分类号： C07D487/04 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/549 , A61K31/55 , A61K31/551 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/20 , C07D491/20 , C07D497/08 , C07D498/04
摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中A1，A2，L1和B如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关病症。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。
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