公开(公告)号：US20140031339A1

公开(公告)日：2014-01-30

申请号：US13942988

申请日：2013-07-16

申请人： Asitha ABEYWARDANE ,  Steven Richard BRUNETTE ,  Michael Jason BURKE ,  Thomas Martin KIRRANE, JR. ,  Chuk Chui MAN ,  Daniel Richard MARSHALL ,  Anil Kumar PADYANA ,  Hossein RAZAVI ,  Robert SIBLEY ,  Lana Louise SMITH KEENAN ,  Roger John SNOW ,  Ronald John SORCEK ,  Hidenori TAKAHASHI ,  Steven John TAYLOR ,  Michael Robert TURNER ,  Erick Richard Roush YOUNG ,  Qiang ZHANG ,  Yunlong ZHANG ,  Renee M. ZINDELL

发明人： Asitha ABEYWARDANE ,  Steven Richard BRUNETTE ,  Michael Jason BURKE ,  Thomas Martin KIRRANE, JR. ,  Chuk Chui MAN ,  Daniel Richard MARSHALL ,  Anil Kumar PADYANA ,  Hossein RAZAVI ,  Robert SIBLEY ,  Lana Louise SMITH KEENAN ,  Roger John SNOW ,  Ronald John SORCEK ,  Hidenori TAKAHASHI ,  Steven John TAYLOR ,  Michael Robert TURNER ,  Erick Richard Roush YOUNG ,  Qiang ZHANG ,  Yunlong ZHANG ,  Renee M. ZINDELL

IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D487/04 ,  C07D498/04 ,  C07D497/08 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/549 ,  A61K31/496 ,  A61K31/4545 ,  A61K31/454 ,  C07D405/12 ,  A61K31/551

CPC分类号： C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/549 ,  A61K31/55 ,  A61K31/551 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D471/20 ,  C07D491/20 ,  C07D497/08 ,  C07D498/04

摘要： The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein A1, A2, L1 and B are as defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中A1，A2，L1和B如本文所定义。 式（I）化合物可用作白三烯A4水解酶（LTA4H）的抑制剂和治疗LTA4H相关疾病。 本发明还涉及包含式（I）化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，以及制备这些化合物的方法。

公开(公告)号：US08527064B2

公开(公告)日：2013-09-03

申请号：US12327601

申请日：2008-12-03

申请人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

发明人： Yunlong Zhang ,  Haresh G. Sachanandani ,  Dan Li ,  Bin Mi

IPC分类号： A61N1/36

CPC分类号： A61N1/0587 ,  A61B5/4035 ,  A61B5/6862 ,  A61B5/6876 ,  A61N1/057 ,  A61N1/36114 ,  A61N1/36117 ,  A61N1/3627 ,  A61N1/37211 ,  A61N1/37288

摘要： Various implantable medical device embodiments stimulate an autonomic neural target from within a pulmonary artery, and comprise at least one electrode, a power supply, a neural stimulator connected to the power supply, and an anchor structure. The neural stimulator is configured to generate a neural stimulation signal for delivery to the neural stimulation target through the at least one electrode. The anchor structure is configured to chronically and securely implant the neural stimulator, the power supply and the at least one electrode within the pulmonary artery. The anchor structure, the neural stimulator, the power supply and the at least one electrode are configured to be implanted through a pulmonary valve into the pulmonary artery. In various embodiments, the neural stimulator is configured to be operational to implement a neural stimulation protocol when chronically implanted within the pulmonary artery without a wired connection through the pulmonary valve.

摘要翻译： 各种可植入医疗装置实施例从肺动脉内刺激自主神经靶标，并且包括至少一个电极，电源，连接到电源的神经刺激器和锚结构。 神经刺激器被配置为产生神经刺激信号，以通过至少一个电极传递到神经刺激靶。 锚结构被配置为长期且牢固地植入神经刺激器，电源和至少一个电极在肺动脉内。 锚结构，神经刺激器，电源和至少一个电极构造成通过肺动脉瓣植入肺动脉。 在各种实施例中，神经刺激器被配置为在长期植入肺动脉内而不通过肺动脉瓣的有线连接的情况下实施神经刺激方案。

公开(公告)号：US20130218221A1

公开(公告)日：2013-08-22

申请号：US13855570

申请日：2013-04-02

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/365 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/395 ,  A61N1/3956

摘要： According to some method embodiments, a left pulmonary artery electrode is positioned in a left pulmonary artery, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation. According to some method embodiments, a right pulmonary artery electrode is positioned in a right pulmonary artery and a left pulmonary artery electrode is positioned in a left pulmonary artery, the right pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation.

摘要翻译： 根据一些方法实施例，左肺动脉电极位于左肺动脉中，并且左肺动脉电极用于感测心房活动或捕获心脏组织或递送神经刺激。 根据一些方法实施例，右肺动脉电极位于右肺动脉中，左肺动脉电极位于左肺动脉中，右肺动脉电极用于感测心房活动或捕获心脏组织，或 传递神经刺激，左肺动脉电极用于感测心房活动或捕获心脏组织，或传递神经刺激。

公开(公告)号：US08494618B2

公开(公告)日：2013-07-23

申请号：US11208922

申请日：2005-08-22

申请人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

发明人： Yunlong Zhang ,  James O. Gilkerson ,  Yongxing Zhang ,  Boyce Moon

IPC分类号： A61B5/04 ,  A61N1/00

CPC分类号： A61N1/3962 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3925

摘要： A system to measure intracardiac impedance includes implantable electrodes and a medical device. The electrodes sense electrical signals of a heart of a subject. The medical device includes a cardiac signal sensing circuit coupled to the implantable electrodes, an impedance measurement circuit coupled to the same or different implantable electrodes, and a controller circuit coupled to the cardiac signal sensing circuit and the impedance measurement circuit. The cardiac signal sensing circuit provides a sensed cardiac signal. The impedance measurement circuit senses intracardiac impedance between the electrodes to obtain an intracardiac impedance signal. The controller circuit determines cardiac cycles of the subject using the sensed cardiac signal, and detects tachyarrhythmia using cardiac-cycle to cardiac-cycle changes in a plurality of intracardiac impedance parameters obtained from the intracardiac impedance signal.

摘要翻译： 测量心内阻抗的系统包括可植入电极和医疗装置。 电极感测受试者心脏的电信号。 医疗装置包括耦合到可植入电极的心脏信号感测电路，耦合到相同或不同可植入电极的阻抗测量电路，以及耦合到心脏信号感测电路和阻抗测量电路的控制器电路。 心脏信号感测电路提供感测的心脏信号。 阻抗测量电路感测电极之间的心内阻抗，以获得心内阻抗信号。 控制器电路使用感测到的心脏信号来确定受试者的心脏周期，并且使用从心脏内阻抗信号获得的多个心内阻抗参数中的心脏周期与心脏周期变化来检测快速性心律失常。

公开(公告)号：US08417355B2

公开(公告)日：2013-04-09

申请号：US12940172

申请日：2010-11-05

申请人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

发明人： Yongxing Zhang ,  Yunlong Zhang ,  Xuan Wei

IPC分类号： A61N1/05

CPC分类号： A61B5/224 ,  A61B5/0464 ,  A61B5/11 ,  A61B5/6846 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627

摘要： A method and apparatus permit sensing one or more forces exerted by one or more portions of a heart. A force transducer and displacement sensor are disclosed. A movement of one or more portions of a heart can be translated into one or more signals indicative of force. These signals can be used to provide information such as to diagnose or treat one or more conditions.

摘要翻译： 一种方法和装置允许感测由心脏的一个或多个部分施加的一个或多个力。 公开了一种力传感器和位移传感器。 心脏的一个或多个部分的运动可以被转换为指示力的一个或多个信号。 这些信号可用于提供诸如诊断或治疗一种或多种病症的信息。

公开(公告)号：US08417354B2

公开(公告)日：2013-04-09

申请号：US12779177

申请日：2010-05-13

申请人： Yongxing Zhang ,  Yunlong Zhang

发明人： Yongxing Zhang ,  Yunlong Zhang

IPC分类号： A61N1/368

CPC分类号： A61N1/365 ,  A61N1/3605 ,  A61N1/36114 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/3627 ,  A61N1/368 ,  A61N1/395 ,  A61N1/3956

摘要： According to some method embodiments, a left pulmonary artery electrode is positioned in a left pulmonary artery, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation. According to some method embodiments, a right pulmonary artery electrode is positioned in a right pulmonary artery and a left pulmonary artery electrode is positioned in a left pulmonary artery, the right pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation, and the left pulmonary artery electrode is used to sense atrial activity, or capture cardiac tissue, or deliver neural stimulation.

摘要翻译： 根据一些方法实施例，左肺动脉电极位于左肺动脉中，并且左肺动脉电极用于感测心房活动或捕获心脏组织或递送神经刺激。 根据一些方法实施例，右肺动脉电极位于右肺动脉中，左肺动脉电极位于左肺动脉中，右肺动脉电极用于感测心房活动或捕获心脏组织，或 传递神经刺激，左肺动脉电极用于感测心房活动或捕获心脏组织，或传递神经刺激。

公开(公告)号：US08258301B2

公开(公告)日：2012-09-04

申请号：US12527973

申请日：2008-05-12

申请人： Brian Nicholas Cook ,  Anne Bettina Eldrup ,  Ingo Andreas Mugge ,  Fariba Soleymanzadeh ,  Sanxing Sun ,  Yunlong Zhang

发明人： Brian Nicholas Cook ,  Anne Bettina Eldrup ,  Ingo Andreas Mugge ,  Fariba Soleymanzadeh ,  Sanxing Sun ,  Yunlong Zhang

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： Compounds of the formula (I) wherein R1, R2, R3, R4, R5, R6, W, and Y are as described herein, or a tautomer, prodrug, solvate, or salt thereof. These compounds are useful as inhibitors of Urotensin II and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the interaction of Urotensin II with its receptor, including cardiovascular diseases. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds, and intermediates useful in these processes.

摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，W和Y如本文所述的式（I）化合物，或其互变异构体，前药，溶剂化物或盐。 这些化合物可用作促进罗素素II的抑制剂，因此可用于治疗通过促肾上腺素II与其受体（包括心血管疾病）的相互作用介导或维持的各种疾病和病症。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US20120190992A1

公开(公告)日：2012-07-26

申请号：US13438682

申请日：2012-04-03

申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

IPC分类号： A61B5/0215 ,  A61B5/042 ,  A61B5/021

CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。

公开(公告)号：US20110163552A1

公开(公告)日：2011-07-07

申请号：US13062391

申请日：2009-09-03

申请人： Yunlong Zhang ,  Hongying Zhang

发明人： Yunlong Zhang ,  Hongying Zhang

IPC分类号： F03D9/00 ,  F03D11/02

CPC分类号： F03D7/0276 ,  F03D1/025 ,  F03D15/00 ,  F05B2260/403 ,  Y02E10/72

摘要： The present invention provides a controllable compound rotor system for the WECS, with a pilot rotor working under low wind speed conditions and a main rotor working under high speed conditions. By proper switching of the clutch, the WECS can not only achieve a greater starting torque under low wind speed conditions, as well as to capture and utilize the low wind-speed wind energy after being started, but also give full play to the advantage of the main rotor having the excellent wind capturing efficiency under high wind speed and high turning speed conditions. Thus the WECS can capture and utilize wind energy under both low and high wind speed conditions, which greatly expands the speed and zone range wherein the WECS can be applied, facilitating wide application of the WECS.

摘要翻译： 本发明提供了一种用于WECS的可控复合转子系统，其中先导转子在低风速条件下工作，主转子在高速条件下工作。 通过适当切换离合器，WECS不但能够在低风速条件下实现更大的启动转矩，而且可以在起动后捕获和利用低风速的风能，同时充分发挥 主转子在高风速和高转速条件下具有优良的风力捕获效率。 因此，WECS可以在低和高风速条件下捕获和利用风能，大大扩展了可应用WECS的速度和区域范围，有助于WECS的广泛应用。

公开(公告)号：US20090281396A1

公开(公告)日：2009-11-12

申请号：US12414465

申请日：2009-03-30

申请人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

发明人： Wangcai Liao ,  Jeffrey Stahmann ,  Bin Mi ,  Yunlong Zhang

IPC分类号： A61B5/0215 ,  A61B5/0205

CPC分类号： A61B5/0215 ,  A61B5/02007 ,  A61B5/02108 ,  A61B5/08 ,  A61B5/412 ,  A61B5/6846 ,  A61B5/7275

摘要： Systems and methods provide for ambulatorily sensing pulmonary artery pressure from within a patient, and producing a pulmonary artery pressure measurement from the sensed pulmonary artery pressure. Power is ambulatorily provided within the patient to facilitate sensing of the pulmonary artery pressure and producing of the pulmonary artery pressure measurement. Acute pulmonary embolism is detected based on a change or rate of change in the pulmonary artery pressure measurement. An alert is preferably generated in response to detecting pulmonary embolism.

摘要翻译： 系统和方法提供了从患者体内动态感测肺动脉压力，并从感测到的肺动脉压力产生肺动脉压力测量。 在患者体内设置动力，以便于感测肺动脉压力并产生肺动脉压力测量。 基于肺动脉压力测量的变化或变化率来检测急性肺栓塞。 响应于检测到肺栓塞，优选产生警报。