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公开(公告)号：US20100280028A1
公开(公告)日：2010-11-04
申请号：US12768268
申请日：2010-04-27
申请人： Jennifer A. KOWALSKI , Daniel Richard MARSHALL , Anthony S. PROKOPOWICZ, III , Sabine SCHLYER , Robert SIBLEY , Ronald John SORCEK , Di WU , Frank WU , Erick Richard Roush YOUNG
发明人： Jennifer A. KOWALSKI , Daniel Richard MARSHALL , Anthony S. PROKOPOWICZ, III , Sabine SCHLYER , Robert SIBLEY , Ronald John SORCEK , Di WU , Frank WU , Erick Richard Roush YOUNG
IPC分类号： A61K31/5377 , C07D403/14 , A61K31/506 , C07D413/14 , A61K31/497 , C07D241/04 , A61K31/4965 , C07D401/12 , A61P29/00 , A61P9/00 , A61P37/00
CPC分类号： C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R5, A, B, D and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1至R 5，A，B，D和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08637550B2
公开(公告)日：2014-01-28
申请号：US13127256
申请日：2009-11-05
申请人： Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Sabine Schlyer , Lana Louise Smith Keenan , Steven John Taylor , Bernd Wellenzohn , Dieter Wiedenmayer , Zhaoming Xiong , Qiang Zhang
发明人： Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Sabine Schlyer , Lana Louise Smith Keenan , Steven John Taylor , Bernd Wellenzohn , Dieter Wiedenmayer , Zhaoming Xiong , Qiang Zhang
IPC分类号： A61K31/443 , C07D405/12 , C07D405/10
CPC分类号： C07D407/10 , C07D231/14 , C07D263/16 , C07D277/56 , C07D307/68 , C07D401/04 , C07D407/14 , C07D411/12 , C07D471/04
摘要： Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).
摘要翻译： 公开了作为MMP-13抑制剂的如本文所述的式（I）的化合物和组合物。 还公开了使用和制备式（I）化合物的方法。
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公开(公告)号：US08450317B2
公开(公告)日：2013-05-28
申请号：US12768268
申请日：2010-04-27
申请人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
发明人： Jennifer A. Kowalski , Daniel Richard Marshall , Anthony S. Prokopowicz, III , Sabine Schlyer , Robert Sibley , Ronald John Sorcek , Di Wu , Frank Wu , Erick Richard Roush Young
IPC分类号： C07D239/34 , C07D239/42 , A61K31/506
CPC分类号： C07D471/04 , C07D209/48 , C07D213/26 , C07D213/56 , C07D213/65 , C07D213/74 , C07D217/00 , C07D231/10 , C07D233/90 , C07D235/04 , C07D239/34 , C07D239/42 , C07D277/30 , C07D295/185 , C07D307/68 , C07D317/68 , C07D319/18 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , C07D491/08
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R5, A, B, D and X are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1至R 5，A，B，D和X如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08697911B2
公开(公告)日：2014-04-15
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A01N37/18 , A61K31/165 , C07C239/00 , C07C279/16 , C07D473/00 , C07D417/00 , C07C45/78 , C07C271/06 , C07D271/12 , C07D413/00 , C07D271/00 , C07D285/02 , C07D285/04 , C07D498/00 , C07D513/00 , C07D277/82 , C07D263/60 , C07D249/04 , C07D249/08 , C07D233/02 , C07D231/00
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08338367B2
公开(公告)日：2012-12-25
申请号：US13123002
申请日：2009-10-13
IPC分类号： A61K38/00 , A61K38/48 , A61K38/55 , A61K31/44 , C07K14/47 , C07K14/81 , A61P9/10 , A61P9/00 , A61P19/02 , A61P29/00 , A61P19/10 , A61P35/00 , A01N43/42
CPC分类号： C07D405/04 , C07D405/14 , C07D471/04
摘要： Disclosed are compounds and compositions of the formula I as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula I.
摘要翻译： 公开了本文所述的式I化合物和组合物，其是MMP-13的抑制剂。 还公开了使用和制备式I化合物的方法。
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公开(公告)号：US20110275625A1
公开(公告)日：2011-11-10
申请号：US13127256
申请日：2009-11-05
申请人： Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Shuang Liang , Sabine Schlyer , Lana Louise Smith Keenan , Steven John Taylor , Bernd Wellenzohn , Dieter Wiedenmayer , Zhaoming Xiong , Qiang Zhang
发明人： Neil Alexander Farrow , Donghong Amy Gao , Alexander Heim-Riether , Shuang Liang , Sabine Schlyer , Lana Louise Smith Keenan , Steven John Taylor , Bernd Wellenzohn , Dieter Wiedenmayer , Zhaoming Xiong , Qiang Zhang
IPC分类号： A61K31/444 , C07D405/04 , A61K31/443 , A61K31/4433 , C07D401/12 , A61K31/4439 , C07D401/14 , A61K31/4178 , C07D407/12 , A61K31/341 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/497 , A61K31/501 , C07D413/12 , A61K31/5377 , A61P29/00 , A61P19/10 , A61P9/10 , A61P9/00 , A61P25/00 , A61P35/00 , C07D405/14
CPC分类号： C07D407/10 , C07D231/14 , C07D263/16 , C07D277/56 , C07D307/68 , C07D401/04 , C07D407/14 , C07D411/12 , C07D471/04
摘要： Disclosed are compounds and compositions of the formula (I) as described herein which are inhibitors of MMP-13. Also disclosed are methods of using and making compounds of the formula (I).
摘要翻译： 公开了作为MMP-13抑制剂的如本文所述的式（I）的化合物和组合物。 还公开了使用和制备式（I）化合物的方法。
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公开(公告)号：US08815857B2
公开(公告)日：2014-08-26
申请号：US13570432
申请日：2012-08-09
申请人： Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
发明人： Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
IPC分类号： A61K31/5377 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D401/04 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D417/04 , C07D417/14
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20120165322A1
公开(公告)日：2012-06-28
申请号：US13171696
申请日：2011-06-29
申请人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
发明人： Brian Nicholas Cook , Jennifer A. Kowalski , Xiang Li , Daniel Richard Marshall , Sabine Schlyer , Robert Sibley , Lana Louise Smith-Keenan , Fariba Soleymanzadeh , Ronald John Sorcek , Erick Richard Roush Young , Yunlong Zhang
IPC分类号： A61K31/472 , A61K31/4725 , C07D471/04 , C07D487/04 , A61K31/4985 , C07D417/14 , C07D417/12 , A61K31/5415 , A61K31/541 , C07D413/12 , C07D413/14 , C07D401/12 , A61K31/506 , C07D405/12 , A61K31/5377 , A61K31/538 , A61K31/497 , A61K31/4439 , C07D513/04 , A61K31/428 , A61P9/12 , A61P9/10 , A61P9/00 , A61P25/00 , A61P15/10 , A61P13/12 , A61P11/06 , A61P27/06 , A61P35/00 , A61P25/28 , A61P29/00 , A61P17/06 , A61P1/00 , A61K31/437 , C07D217/02
CPC分类号： C07D217/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1和R 2如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US20130203729A1
公开(公告)日：2013-08-08
申请号：US13570432
申请日：2012-08-09
申请人： Todd BOSANAC , Angela BERRY , John David GINN , Tamara Denise HOPKINS , Sabine SCHLYER , Fariba SOLEYMANZADEH , John WESTBROOK , Maolin YU , Zhonghua ZHANG
发明人： Todd BOSANAC , Angela BERRY , John David GINN , Tamara Denise HOPKINS , Sabine SCHLYER , Fariba SOLEYMANZADEH , John WESTBROOK , Maolin YU , Zhonghua ZHANG
IPC分类号： C07D417/14 , C07D417/04 , C07D417/12
CPC分类号： C07D417/14 , C07D417/04 , C07D417/12
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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公开(公告)号：US08362249B2
公开(公告)日：2013-01-29
申请号：US12764136
申请日：2010-04-21
申请人： John David Ginn , Daniel Richard Marshall , Anthony S. Prokopowicz , Sabine Schlyer , Robert Sibley , Michael Robert Turner , Di Wu , Frank Wu
发明人： John David Ginn , Daniel Richard Marshall , Anthony S. Prokopowicz , Sabine Schlyer , Robert Sibley , Michael Robert Turner , Di Wu , Frank Wu
IPC分类号： C07D231/12 , C07D401/12 , C07D401/14 , C07D413/12 , C07D471/04 , C07D513/04 , A61K31/496
CPC分类号： C07D403/06 , C07D401/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1 to R6, A, B, X, Y and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1至R 6，A，B，X，Y和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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