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公开(公告)号：US20060264486A1
公开(公告)日：2006-11-23
申请号：US10555024
申请日：2004-04-28
Applicant: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
Inventor： Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
IPC: A61K31/422 , C07D413/02
CPC classification number: C07D403/12 , C07D209/08 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
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![Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-C]pyridine derivatives for the treatment of obesity](/abs-image/US/2006/06/08/US20060122215A1/abs.jpg.150x150.jpg)
2.发明申请Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-C]pyridine derivatives for the treatment of obesity 审中-公开1,5,6,7-四氢吡咯并[3,2-C]吡啶衍生物的制备和用途，用于治疗肥胖症公开(公告)号：US20060122215A1
公开(公告)日：2006-06-08
申请号：US11335349
申请日：2006-01-18
Applicant: Roger Smith , Stephen O'Connor , Wai Wong , Soongyu Choi , Harold Kluender , Jianmei Fan , Zhonghua Zhang , Rico Lavoie , Brent Podlogar
Inventor： Roger Smith , Stephen O'Connor , Wai Wong , Soongyu Choi , Harold Kluender , Jianmei Fan , Zhonghua Zhang , Rico Lavoie , Brent Podlogar
IPC: C07D471/02 , A61K31/4745
CPC classification number: C07D471/04
Abstract: This invention relates to 1,5,6,7-tetrahydropynolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
Abstract translation: 本发明涉及已被发现抑制食欲并引起体重减轻的1,5,6,7-四氢异噻唑并[3,2-c]吡啶衍生物。 本发明还提供了合成化合物的方法，包含该化合物的药物组合物，以及使用这些组合物诱导体重减轻和治疗肥胖症和肥胖相关疾病的方法。
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公开(公告)号：US08815857B2
公开(公告)日：2014-08-26
申请号：US13570432
申请日：2012-08-09
Applicant: Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
Inventor： Todd Bosanac , Angela Berry , John David Ginn , Tamara Denise Hopkins , Sabine Schlyer , Fariba Soleymanzadeh , John Westbrook , Maolin Yu , Zhonghua Zhang
IPC: A61K31/5377 , A61K31/454 , A61K31/4545 , C07D401/14 , C07D401/04 , C07D401/12 , C07D413/14 , C07D413/12 , C07D417/12 , C07D417/04 , C07D417/14
CPC classification number: C07D417/14 , C07D417/04 , C07D417/12
Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1-R5 and n are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
Abstract translation: 本发明涉及式（I）化合物及其药学上可接受的盐，其中R 1 -R 5和n如本文所定义。 本发明还涉及包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。
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4.发明申请SUBSTITUTED 4-AMINO-PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权取代的4-氨基吡咯烷酮衍生物有助于治疗与增殖性疾病有关的高血压病和疾病公开(公告)号：US20120165314A1
公开(公告)日：2012-06-28
申请号：US13414392
申请日：2012-03-07
Applicant: Julie Dixon , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C.E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Steven Magnuson , Kristen M. Allegue , Zheng Liu
Inventor： Julie Dixon , Barton Phillips , Yamin Wang , Tindy Li , Kyle Parcella , Jason Newcom , Harold C.E. Kluender , Zhenqiu Hong , Brent Chandler , Zhonghua Zhang , Steven Magnuson , Kristen M. Allegue , Zheng Liu
IPC: A61K31/53 , A61P35/00 , A61K31/541 , A61K31/553 , C07D487/04 , A61K31/5377
CPC classification number: C07D487/04
Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
Abstract translation: 本发明涉及新颖的吡唑并三嗪化合物，含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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公开(公告)号：US07964622B2
公开(公告)日：2011-06-21
申请号：US12508314
申请日：2009-07-23
Applicant: Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
Inventor： Xin Ma , Louis-David Cantin , Soongyu Choi , Roger Clark , Martin Hentemann , Joachim Rudolph , Rico Lavoie , Zhonghua Zhang
IPC: A61K31/425 , A61K31/42 , C07D417/00 , C07D277/20 , C07D498/00 , C07D263/30
CPC classification number: C07D403/12 , C07D209/08 , C07D401/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D513/04
Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
Abstract translation: 本发明涉及吲哚乙酸衍生物及其在药物组合物中用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的用途。 本发明还涉及可用于制备吲哚乙酸衍生物的中间体和制备方法。
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Patent Agency Ranking
6.发明申请PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING CANCER THROUGH INHIBITION OF AURORA KINASE 有权用于通过抑制激素激酶治疗癌症的吡咯烷酮衍生物公开(公告)号：US20100273800A1
公开(公告)日：2010-10-28
申请号：US12679787
申请日：2008-09-22
Applicant: Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
Inventor： Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
IPC: A61K31/53 , C07D253/10 , C12N9/99 , A61P35/00 , A61J1/05
CPC classification number: C07D487/04
Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
Abstract translation: 本发明涉及新化合物及其制备方法，治疗疾病，特别是癌症的方法，包括给药所述化合物，以及制备用于治疗或预防病症，特别是癌症的药物组合物的方法。
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公开(公告)号：US08143393B2
公开(公告)日：2012-03-27
申请号：US12085880
申请日：2006-12-01
Applicant: Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
Inventor： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC: C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04
Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
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8.发明授权公开(公告)号：US08138336B2
公开(公告)日：2012-03-20
申请号：US12679787
申请日：2008-09-22
Applicant: Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
Inventor： Steven Magnuson , Philip Wickens , Zhonghua Zhang , Ning Qi , Xin Ma
IPC: C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61P35/00
CPC classification number: C07D487/04
Abstract: This invention relates to novel compounds and processes for their preparation, methods of treating diseases, particularly Cancer, comprising administering said compounds, and methods of making pharmaceutical compositions for the treatment or prevention of disorders, particularly Cancer.
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9.发明授权Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权用于治疗高增殖性疾病和与血管发生相关的疾病的取代的4-氨基吡咯并三嗪衍生物公开(公告)号：US08129379B2
公开(公告)日：2012-03-06
申请号：US12552923
申请日：2009-09-02
Applicant: Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
Inventor： Julie A. Dixon , Barton Phillips , Furahi Achebe , Harold C. E. Kluender , Jason Newcom , Kyle Parcella , Steven Magnuson , Zhenqiu Hong , Zhonghua Zhang , Zheng Liu , Uday Khire , Lei Wang , Martin Michels , Brent Chandler , Stephen O'Connor
IPC: A61K31/53 , A61P35/00 , C07D487/04 , C07D417/02 , C07D413/02
CPC classification number: C07D487/04
Abstract: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
Abstract translation: 本发明涉及新颖的吡咯并三嗪化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。
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![Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity](/abs-image/US/2006/07/04/US07071207B2/abs.jpg.150x150.jpg)
10.发明授权Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity 失效1,5,6,7-四氢吡咯并[3,2-c]吡啶衍生物的制备和用途，用于治疗肥胖症公开(公告)号：US07071207B2
公开(公告)日：2006-07-04
申请号：US10487976
申请日：2002-09-24
Applicant: Roger A. Smith , Stephen J. O'Connor , Wai C. Wong , Soongyu Choi , Harold C. Kluender , Jianmei Fan , Zhonghua Zhang , Rico C. Lavoie , Brent L. Podlogar
Inventor： Roger A. Smith , Stephen J. O'Connor , Wai C. Wong , Soongyu Choi , Harold C. Kluender , Jianmei Fan , Zhonghua Zhang , Rico C. Lavoie , Brent L. Podlogar
IPC: A61K31/40 , A61K31/395 , A61K31/437 , C07D471/04 , C07D471/14
CPC classification number: C07D471/04
Abstract: This invention relates to 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
Abstract translation: 本发明涉及已被发现抑制食欲并引起体重减轻的1,5,6,7-四氢吡咯并[3,2-c]吡啶衍生物。 本发明还提供了合成化合物的方法，包含该化合物的药物组合物，以及使用这些组合物诱导体重减轻和治疗肥胖症和肥胖相关疾病的方法。
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