公开(公告)号：US08606361B2

公开(公告)日：2013-12-10

申请号：US13179133

申请日：2011-07-08

Applicant: Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

Inventor： Bradford Evan Gliner ,  Allen Wyler ,  Brad Fowler ,  W. Douglas Sheffield ,  Richard Kuntz ,  Kent Leyde ,  Leif R. Sloan

IPC: A61N1/36

CPC classification number: H04L67/2842 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/3606 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37252 ,  G06F13/385 ,  H04L49/90 ,  H04L49/901 ,  H04L67/2823

Abstract: Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.

公开(公告)号：US20130238059A1

公开(公告)日：2013-09-12

申请号：US13860686

申请日：2013-04-11

Applicant: Randall YORK ,  Scott KOKONES ,  Keith CARLTON ,  Alan GRESZLER

Inventor： Randall YORK ,  Scott KOKONES ,  Keith CARLTON ,  Alan GRESZLER

IPC: A61N1/36

CPC classification number: A61N1/36103 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/3615

Abstract: Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses.

Abstract translation: 活体哺乳动物受试者（例如人类患者）中神经调节的方法。 该方法包括将电信号施加到诸如脑的神经系统中的目标部位，其中电信号包括一系列脉冲。 脉冲包括与对应的矩形波形相比更节能的波形形状。 这种能量效率波形的非限制性实例包括线性增加，线性递减，指数增加，指数减小和高斯波形。 还描述了用于神经调节的装置和用于操作这种装置的软件。

公开(公告)号：US08515541B1

公开(公告)日：2013-08-20

申请号：US11317465

申请日：2005-12-22

Applicant: Kristen N. Jaax ,  Todd K. Whitehurst ,  Rafael Carbunaru

Inventor： Kristen N. Jaax ,  Todd K. Whitehurst ,  Rafael Carbunaru

IPC: A61N1/36

CPC classification number: A61N1/0531 ,  A61N1/0539 ,  A61N1/36103 ,  A61N1/37205 ,  A61N1/3756

Abstract: Methods of treating a post-stroke disorder include applying at least one stimulus to a stimulation site within a patient with an implanted stimulator in accordance with one or more stimulation parameters. The stimulation site may include, for example, at least one or more of a motor cortex, thalamus, cerebellum, basal ganglia, globus pallidus, and periaqueductal gray. Systems for treating a post-stroke disorder include an implantable stimulator configured to apply at least one stimulus to a stimulation site within a patient in accordance with one or more stimulation parameters. The stimulation site may include, for example, at least one or more of a motor cortex, thalamus, cerebellum, basal ganglia, globus pallidus, and periaqueductal gray.

Abstract translation: 治疗中风后病症的方法包括根据一个或多个刺激参数，使用植入的刺激器将至少一种刺激施加到患者内的刺激部位。 刺激部位可以包括例如运动皮层，丘脑，小脑，基底神经节，苍白球和周围导管灰色中的至少一个或多个。 用于治疗中风后病症的系统包括可植入刺激器，其被配置为根据一个或多个刺激参数将至少一种刺激施加到患者内的刺激部位。 刺激部位可以包括例如运动皮层，丘脑，小脑，基底神经节，苍白球和周围导管灰色中的至少一个或多个。

公开(公告)号：US08509903B2

公开(公告)日：2013-08-13

申请号：US12479067

申请日：2009-06-05

Applicant: Randall York ,  Scott Kokones ,  Keith Carlton ,  Alan Greszler

Inventor： Randall York ,  Scott Kokones ,  Keith Carlton ,  Alan Greszler

IPC: A61N1/36 ,  A61N1/3605 ,  A61N1/36014 ,  A61N1/40

CPC classification number: A61N1/36103 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/3615

Abstract: Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses.

Abstract translation: 活体哺乳动物受试者（例如人类患者）中神经调节的方法。 该方法包括将电信号施加到诸如脑的神经系统中的目标部位，其中电信号包括一系列脉冲。 脉冲包括与对应的矩形波形相比更节能的波形形状。 这种能量效率波形的非限制性实例包括线性增加，线性递减，指数增加，指数减小和高斯波形。 还描述了用于神经调节的装置和用于操作这种装置的软件。

公开(公告)号：US08489185B2

公开(公告)日：2013-07-16

申请号：US12485857

申请日：2009-06-16

Applicant: Michael Kilgard ,  Larry Cauller ,  Navzer Engineer ,  Christa McIntyre ,  Will Rosellini

Inventor： Michael Kilgard ,  Larry Cauller ,  Navzer Engineer ,  Christa McIntyre ,  Will Rosellini

IPC: A61N1/00

CPC classification number: A61N1/36167 ,  A61F11/00 ,  A61M21/00 ,  A61M21/02 ,  A61M2021/0016 ,  A61M2021/0022 ,  A61M2021/0027 ,  A61M2021/0044 ,  A61M2021/0072 ,  A61M2021/0077 ,  A61M2205/3515 ,  A61M2230/06 ,  A61M2230/08 ,  A61M2230/10 ,  A61M2230/205 ,  A61M2230/30 ,  A61M2230/432 ,  A61M2230/50 ,  A61M2230/60 ,  A61M2230/65 ,  A61N1/36014 ,  A61N1/36053 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36092 ,  A61N1/361 ,  A61N1/36103 ,  A61N1/36139 ,  A61N5/0618 ,  A61N5/0622 ,  G09B19/00 ,  G09B19/003 ,  G09B23/28 ,  H04R25/75

Abstract: Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training. Stimulations of nerves such as the vagus nerve that affect subcortical regions such as the nucleus basalis, locus coeruleus or amygdala induce plasticity in the brain, enhancing the effects of a variety of therapies, such as those used to treat tinnitus, stroke, traumatic brain injury and post-traumatic stress disorder.

Abstract translation: 用于配对训练的系统，方法和装置包括时间控制，以便可以同时提供训练和神经刺激。 配对培训可能包括治疗，康复和绩效增强培训。 影响神经的神经刺激，如影响皮层下的区域，如基底核，坐骨神经或杏仁核诱导脑中的可塑性，增强各种疗法的作用，例如用于治疗耳鸣，中风，创伤性脑损伤 和创伤后应激障碍。

公开(公告)号：US20130041419A1

公开(公告)日：2013-02-14

申请号：US13651349

申请日：2012-10-12

Applicant: MicroTransponder, Inc. ,  The Board of Regents, The University of Texas Sy

Inventor： Michael P. Kilgard ,  Navzer Engineer ,  David Michael Pierce ,  Robert L. Rennaker

IPC: A61N1/00

CPC classification number: A61N1/36067 ,  A61B5/1124 ,  A61N1/36003 ,  A61N1/36053 ,  A61N1/36092 ,  A61N1/361 ,  A61N1/36103 ,  A61N1/36132 ,  A61N1/36139 ,  A61N1/36178 ,  A61N1/37217 ,  A61N1/37235 ,  A61N1/37247 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026 ,  G06F19/00 ,  G09B23/28

Abstract: A method of treating motor deficits in a stroke patient, comprising assessing a patient's motor deficits, determining therapeutic goals for the patient, based on the patient's motor deficits, selecting therapeutic tasks based on the therapeutic goals, performing each of the selected therapeutic tasks repetitively, observing the performance of the therapeutic tasks, initiating the stimulation of the vagus nerve manually at approximately a predetermined moment during the performance of the therapeutic tasks, stimulating the vagus nerve of the patient during the performance of the selected therapeutic tasks, and improving the patient's motor deficits.

Abstract translation: 一种治疗卒中患者的运动障碍的方法，包括评估患者的运动缺陷，基于患者运动障碍确定患者的治疗目标，基于治疗目标选择治疗任务，重复执行所选择的治疗任务， 观察治疗任务的性能，在执行治疗任务期间大约预定的时刻手动地启动迷走神经的刺激，在执行所选择的治疗任务期间刺激患者的迷走神经，并改善患者的运动 赤字。

公开(公告)号：US08233976B2

公开(公告)日：2012-07-31

申请号：US12214557

申请日：2008-06-18

Applicant: Ralph G. Dacey, Jr. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel

Inventor： Ralph G. Dacey, Jr. ,  Gregory J. Della Rocca ,  Colin P. Derdeyn ,  Joshua L. Dowling ,  Eleanor V. Goodall ,  Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Jordin T. Kare ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Michael A. Smith ,  Lowell L. Wood, Jr. ,  Victoria Y. H. Wood ,  Gregory J. Zipfel

IPC: A61N1/18

CPC classification number: A61M5/14276 ,  A61B5/0205 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0402 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/1118 ,  A61B5/14539 ,  A61B5/4035 ,  A61B5/4041 ,  A61B5/411 ,  A61B5/441 ,  A61B5/4821 ,  A61B5/4839 ,  A61F7/00 ,  A61F7/0085 ,  A61F2007/0075 ,  A61M5/14244 ,  A61M5/14248 ,  A61M5/16827 ,  A61M5/1723 ,  A61M35/00 ,  A61M37/00 ,  A61M37/0015 ,  A61M37/0092 ,  A61M2005/14208 ,  A61M2005/1726 ,  A61M2037/0007 ,  A61M2205/0244 ,  A61M2210/1003 ,  A61N1/0412 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/303 ,  A61N1/306 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36103 ,  A61N1/36135 ,  A61N1/37252 ,  A61N2/002 ,  A61N2/006 ,  A61N7/00 ,  A61N2007/0026

Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Systems for transdermal delivery of chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.

Abstract translation: 公开了通过用化学阻断剂重复地阻断外周神经结构传导来调节神经活动的方法和相关系统。 公开了用于透皮递送化学阻断剂的系统。 还公开了用于逆转化学阻断剂的作用和/或用于产生基本上永久的传导阻滞的方法和系统。

公开(公告)号：US20120136410A1

公开(公告)日：2012-05-31

申请号：US13365549

申请日：2012-02-03

Applicant: Ali Rezai ,  Andre Machado ,  Keith Carlton

Inventor： Ali Rezai ,  Andre Machado ,  Keith Carlton

IPC: A61N1/36

CPC classification number: A61N1/36103 ,  A61N1/00 ,  A61N1/0529 ,  A61N1/36 ,  A61N1/36067 ,  A61N1/37229

Abstract: A method is provided for neuromodulation to treat stroke. One step of the method includes recording an input waveform from a first site in the nervous system in a source subject. The first site is healthy or at least partially functioning. Next, an output waveform is applied to a second site in the nervous system of a target subject suffering from the stoke. The second site is diseased due to the stroke.

Abstract translation: 提供神经调节治疗中风的方法。 该方法的一个步骤包括从源对象中的神经系统中的第一位置记录输入波形。 第一个网站是健康的或至少部分功能。 接下来，输出波形被施加到遭受脚蹬的目标对象的神经系统中的第二位置。 第二个部位由于中风而患病。

公开(公告)号：US20120053655A1

公开(公告)日：2012-03-01

申请号：US13138268

申请日：2009-12-15

Applicant: Duncan Bain ,  Arthur Tucker ,  Bernard Ross

Inventor： Duncan Bain ,  Arthur Tucker ,  Bernard Ross

IPC: A61N1/00

CPC classification number: A61N1/0452 ,  A61N1/205 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/39

Abstract: Methods and devices are described for preventing diastolic flow reversal and/or reducing peripheral vascular resistance in a patient. Also described are methods of cosmetic treatment, and methods of promoting delivery of therapeutic agents or contrast agents to bones and related tissues.

Abstract translation: 描述了用于预防患者舒张期逆转和/或减少外周血管阻力的方法和装置。 还描述了美容治疗的方法，以及促进治疗剂或造影剂递送到骨骼和相关组织的方法。

公开(公告)号：US08019425B2

公开(公告)日：2011-09-13

申请号：US12343454

申请日：2008-12-23

Applicant: Andrew D. Firlik ,  Jeffrey Balzer ,  Alan J. Levy ,  Bradford Evan Gliner ,  Katrina S. Firlik

Inventor： Andrew D. Firlik ,  Jeffrey Balzer ,  Alan J. Levy ,  Bradford Evan Gliner ,  Katrina S. Firlik

IPC: A61N1/00

CPC classification number: A61N1/36017 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/08 ,  A61N1/36021 ,  A61N1/36025 ,  A61N1/36071 ,  A61N1/36082 ,  A61N1/36103 ,  A61N1/3756

Abstract: Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.

Abstract translation: 用于治疗患者脑部受损的神经功能的方法和装置。 在一个实施方案中，用于治疗患者脑部神经功能的方法包括确定要执行多个治疗期间以恢复与神经功能相对应的功能能力的治疗期。 该方法通过识别与神经功能相关联的患者的脑中或其上的刺激部位，并且将电极定位至少接近所识别的刺激部位来继续。 然后通过向刺激部位提供电刺激治疗来治疗患者。 治疗可以包括在治疗期间向电极传送电刺激信号。 在治疗期满后，该方法包括防止电刺激信号传递到刺激部位。