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公开(公告)号：US08989858B2
公开(公告)日：2015-03-24
申请号：US12214558
申请日：2008-06-18
Applicant: Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
Inventor： Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
IPC: A61N1/18 , A61N1/36 , A61B5/04 , A61B5/00 , A61M5/142 , A61M5/172 , A61M37/00 , A61N1/30 , A61N1/32 , A61N2/00 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/145 , A61F7/00 , A61M5/168 , A61N1/04 , A61N1/365 , A61N1/372 , A61N7/00
CPC classification number: A61N1/36014 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/04001 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/14539 , A61B5/4041 , A61B5/411 , A61B5/441 , A61B5/4839 , A61F7/00 , A61M5/14244 , A61M5/14276 , A61M5/16827 , A61M5/1723 , A61M37/0015 , A61M2005/14208 , A61M2005/1726 , A61M2037/0007 , A61M2205/0244 , A61M2210/1003 , A61N1/0412 , A61N1/0428 , A61N1/303 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/3605 , A61N1/36189 , A61N1/36535 , A61N1/36542 , A61N1/37252 , A61N2/006 , A61N7/00
Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Implantable systems for delivery of chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.
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2.发明授权Device, method, and system for neural modulation as vaccine adjuvant in a vertebrate subject 有权用于神经调制的装置，方法和系统作为脊椎动物受试者中的疫苗佐剂公开(公告)号：US08321012B2
公开(公告)日：2012-11-27
申请号：US12655195
申请日：2009-12-22
Applicant: Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
Inventor： Gregory J. Della Rocca , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Jordin T. Kare , Muriel Y. Ishikawa , Eric C. Leuthardt , Stephen L. Malaska , Nathan P. Myhrvold , Paul Santiago , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
IPC: A61N1/18
CPC classification number: A61M37/00 , A61F7/00 , A61K39/39 , A61M37/0092 , A61N1/303 , A61N1/306 , A61N1/32 , A61N1/36121 , A61N2/00 , A61N2/002 , A61N2/006 , A61N2/02 , A61N5/0622
Abstract: A method for enhancing an immune response in a vertebrate subject is described. The method includes providing at least one energy stimulus configured to modulate one or more nervous system components of the vertebrate subject, and administering one or more immunogen to the vertebrate subject, wherein the at least one energy stimulus and the one or more immunogen are provided in a combination and in a temporal sequence sufficient to enhance an immune response in the vertebrate subject.
Abstract translation: 描述了一种增强脊椎动物受试者免疫应答的方法。 该方法包括提供至少一种能量刺激，其被配置成调节脊椎动物对象的一个或多个神经系统组分，以及向脊椎动物受试者施用一种或多种免疫原，其中所述至少一种能量刺激和所述一种或多种免疫原提供于 组合和时间序列，足以增强脊椎动物受试者的免疫应答。
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公开(公告)号：US08180447B2
公开(公告)日：2012-05-15
申请号：US12214758
申请日：2008-06-18
Applicant: Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y.H. Wood , Gregory J. Zipfel
Inventor： Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y.H. Wood , Gregory J. Zipfel
IPC: A61N1/18
CPC classification number: A61M5/14276 , A61B5/0205 , A61B5/021 , A61B5/024 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/1118 , A61B5/14539 , A61B5/4035 , A61B5/4041 , A61B5/411 , A61B5/441 , A61B5/4821 , A61B5/4839 , A61F7/00 , A61F7/0085 , A61F2007/0075 , A61M5/14244 , A61M5/14248 , A61M5/16827 , A61M5/1723 , A61M35/00 , A61M37/00 , A61M37/0015 , A61M37/0092 , A61M2005/14208 , A61M2005/1726 , A61M2037/0007 , A61M2205/0244 , A61M2210/1003 , A61N1/0412 , A61N1/0428 , A61N1/30 , A61N1/303 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/36103 , A61N1/36135 , A61N1/37252 , A61N2/002 , A61N2/006 , A61N7/00 , A61N2007/0026
Abstract: Methods and related systems for modulating neural activity by repetitively blocking conduction in peripheral neural structures with chemical blocking agents are disclosed. Methods and systems for reversing effects of chemical blocking agents and/or for producing substantially permanent conduction block are also disclosed.
Abstract translation: 公开了通过用化学阻断剂重复地阻断外周神经结构传导来调节神经活动的方法和相关系统。 还公开了用于逆转化学阻断剂的作用和/或用于产生基本上永久的传导阻滞的方法和系统。
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4.发明授权公开(公告)号：US08180446B2
公开(公告)日：2012-05-15
申请号：US11999721
申请日：2007-12-05
Applicant: Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
Inventor： Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
IPC: A61N1/18
CPC classification number: A61N1/36071 , A61B5/04001 , A61N1/36167 , A61N1/36535 , A61N1/36542
Abstract: Methods and related systems for modulating neural activity by repetitively or cyclically blocking conduction in a peripheral neural structure are disclosed. Timing of delivery of blocking stimuli may be based upon overall activity level of the subject or use/activity of a portion of the body of a subject.
Abstract translation: 公开了通过重复或循环阻断外周神经结构传导来调节神经活动的方法和相关系统。 递送阻塞刺激的时间可以基于受试者的总体活动水平或受试者身体的一部分的使用/活动。
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公开(公告)号：US08170660B2
公开(公告)日：2012-05-01
申请号：US12080789
申请日：2008-04-04
Applicant: Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
Inventor： Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
IPC: A61N1/18
CPC classification number: A61F7/00 , A61B5/4035 , A61B5/411 , A61F2007/0075 , A61N1/36021 , A61N1/36071 , A61N1/36535 , A61N1/36542 , A61N1/403 , A61N2/00 , A61N7/00 , A61N2005/0659
Abstract: Methods and related systems for modulating neural activity by blocking conduction in peripheral neural structures with thermal stimuli are disclosed. Methods and systems for reversing effects of thermal blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
Abstract translation: 公开了通过用热刺激阻断外周神经结构传导来调节神经活动的方法和相关系统。 还公开了用于逆转热阻止刺激的作用和/或用于产生基本上永久的传导阻滞的方法和系统。
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Patent Agency Ranking
公开(公告)号：US08170659B2
公开(公告)日：2012-05-01
申请号：US12080787
申请日：2008-04-04
Applicant: Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
Inventor： Ralph G. Dacey, Jr. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
IPC: A61N1/18
CPC classification number: A61F7/00 , A61B5/4035 , A61B5/411 , A61F2007/0075 , A61N1/36021 , A61N1/36071 , A61N1/36535 , A61N1/36542 , A61N1/403 , A61N2/00 , A61N7/00 , A61N2005/0659
Abstract: Methods and related systems for modulating neural activity by blocking conduction in peripheral neural structures with thermal stimuli are disclosed. Methods and systems for reversing effects of thermal blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
Abstract translation: 公开了通过用热刺激阻断外周神经结构传导来调节神经活动的方法和相关系统。 还公开了用于逆转热阻止刺激的作用和/或用于产生基本上永久的传导阻滞的方法和系统。
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公开(公告)号：US08163003B2
公开(公告)日：2012-04-24
申请号：US11901693
申请日：2007-09-17
Applicant: Edward S. Boyden , Ralph G. Dacey, Jr. , Colin P. Derdeyn , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
Inventor： Edward S. Boyden , Ralph G. Dacey, Jr. , Colin P. Derdeyn , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
CPC classification number: A61F2/02 , A61B18/18 , A61B18/245 , A61F2/06 , A61F2/82 , A61F2250/0002 , A61N7/00 , B33Y70/00 , B33Y80/00 , G06F19/00 , G06Q50/22 , G06Q50/24
Abstract: Methods, apparatuses, computer program products, devices and systems are described that include accepting one or more blood vessel sleeve dimensions based on blood vessel data from an individual; and making a rapid-prototyped blood vessel sleeve at least partly based on the one or more blood vessel sleeve dimensions.
Abstract translation: 描述了包括基于来自个体的血管数据接受一个或多个血管套筒尺寸的方法，装置，计算机程序产品，装置和系统; 以及至少部分地基于一个或多个血管套筒尺寸制造快速原型血管套管。
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公开(公告)号：US08095382B2
公开(公告)日：2012-01-10
申请号：US11888623
申请日：2007-07-31
Applicant: Edward S. Boyden , Ralph G. Dacey, Jr. , Colin P. Derdeyn , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
Inventor： Edward S. Boyden , Ralph G. Dacey, Jr. , Colin P. Derdeyn , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Eric C. Leuthardt , Nathan P. Myhrvold , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood , Gregory J. Zipfel
IPC: G06Q50/00
CPC classification number: A61F2/06 , A61B5/02007 , A61B6/481 , A61B6/504 , A61F2/30942 , A61F2002/30065 , A61F2002/30075 , A61F2002/30077 , A61F2002/30087 , A61F2002/30088 , A61F2002/30199 , A61F2002/30617 , A61F2002/3071 , A61F2210/0061 , A61F2210/0066 , A61F2210/0071 , A61F2210/008 , A61F2230/0063 , A61F2240/002 , A61F2250/0085 , A61F2250/0097 , B29C64/386 , B29L2031/7534 , B33Y50/00 , B33Y80/00 , G06F19/00 , G06Q10/06 , G06Q10/087 , G06Q50/22 , G16H50/50
Abstract: Methods, apparatuses, computer program products, devices and systems are described that include accepting three-dimensional blood vessel data; applying a sleeve-fitting algorithm to the three-dimensional blood vessel data; and presenting a sleeve-fitting algorithm output in response to said applying the sleeve-fitting algorithm to the three-dimensional blood vessel data.
Abstract translation: 描述了包括接受三维血管数据的方法，装置，计算机程序产品，装置和系统; 对三维血管数据应用套管拟合算法; 以及响应于将所述套筒拟合算法应用于所述三维血管数据，呈现套筒拟合算法输出。
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9.发明申请公开(公告)号：US20100145412A1
公开(公告)日：2010-06-10
申请号：US12380553
申请日：2009-02-27
Applicant: Edward S. Boyden , Ralph G. Dacey, JR. , Gregory J. Della Rocca , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Paul Santiago , Michael A. Smith , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
Inventor： Edward S. Boyden , Ralph G. Dacey, JR. , Gregory J. Della Rocca , Joshua L. Dowling , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Dennis J. Rivet , Paul Santiago , Michael A. Smith , Todd J. Stewart , Elizabeth A. Sweeney , Clarence T. Tegreene , Lowell L. Wood, JR. , Victoria Y.H. Wood
IPC: A61N1/08
CPC classification number: A61F2/30 , A61F2/32 , A61F2002/30087 , A61F2002/3067 , A61F2002/30677 , A61F2002/48 , A61F2002/481 , A61F2002/482 , A61F2250/0002 , A61F2310/0097 , A61L2/0011 , A61L2/08 , A61L2/14 , A61L2202/14 , A61L2202/24 , A61M5/001 , A61N1/205 , A61N1/37252 , A61N1/3785 , A61N1/3787
Abstract: Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.
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公开(公告)号：US20090149926A1
公开(公告)日：2009-06-11
申请号：US12080789
申请日：2008-04-04
Applicant: Ralph G. Dacey, JR. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, JR. , Victoria Y.H. Wood , Gregory J. Zipfel
Inventor： Ralph G. Dacey, JR. , Gregory J. Della Rocca , Colin P. Derdeyn , Joshua L. Dowling , Eleanor V. Goodall , Roderick A. Hyde , Muriel Y. Ishikawa , Jordin T. Kare , Eric C. Leuthardt , Nathan P. Myhrvold , Michael A. Smith , Lowell L. Wood, JR. , Victoria Y.H. Wood , Gregory J. Zipfel
IPC: A61B18/00
CPC classification number: A61F7/00 , A61B5/4035 , A61B5/411 , A61F2007/0075 , A61N1/36021 , A61N1/36071 , A61N1/36535 , A61N1/36542 , A61N1/403 , A61N2/00 , A61N7/00 , A61N2005/0659
Abstract: Methods and related systems for modulating neural activity by blocking conduction in peripheral neural structures with thermal stimuli are disclosed. Methods and systems for reversing effects of thermal blocking stimuli and/or for producing substantially permanent conduction block are also disclosed.
Abstract translation: 公开了通过用热刺激阻断外周神经结构传导来调节神经活动的方法和相关系统。 还公开了用于逆转热阻止刺激的作用和/或用于产生基本上永久的传导阻滞的方法和系统。
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