公开(公告)号：US10385005B2

公开(公告)日：2019-08-20

申请号：US15995645

申请日：2018-06-01

申请人： OHIO UNIVERSITY

发明人： Xiaozhuo Chen ,  Stephen Bergmeier

IPC分类号： C07C205/32 ,  C07C211/48 ,  C07C39/367 ,  C07C43/23 ,  C07C235/56 ,  C07C43/253 ,  A61K31/09 ,  C07D209/08 ,  C07D231/12 ,  C07D233/64 ,  C07D235/18 ,  C07D249/08 ,  C07D319/20 ,  C07D311/16 ,  C07D311/82 ,  A61K45/06 ,  A61K31/166

摘要： Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates. Specifically blocking these processes is likely to provide new insights to the role of glucose transport and metabolism in tumorigenesis, as well as in apoptosis. As solid tumors outgrow the surrounding vasculature, they encounter microenvironments with a limited supply of nutrients leading to a glucose deprived environment in some regions of the tumor. Cancer cells living in the glucose deprived environment undergo changes to prevent glucose deprivation-induced apoptosis. Knowing how cancer cells evade apoptosis induction is also likely to yield valuable information and knowledge of how to overcome the resistance to apoptosis induction in cancer cells. Disclosed herein are novel anticancer compounds that inhibit basal glucose transport, resulting in tumor suppression and new methods for the study of glucose deprivation in animal cancer research.

公开(公告)号：US10221143B2

公开(公告)日：2019-03-05

申请号：US15550259

申请日：2016-03-01

申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY

发明人： Carl Wagner ,  Peter Jurutka ,  Pamela Marshall

IPC分类号： A61K31/136 ,  C07C211/48 ,  C07D239/42 ,  C07D213/79 ,  C07D237/24 ,  C07D241/28 ,  C07C229/60 ,  C07D213/80

摘要： The invention provides alkyl benzene compounds. The compounds are useful for treating conditions including Alzheimer's disease, Parkinson's disease, diabetes, cancer, inflammation, hyperresponsiveness, allergic conditions, asthma, and psychotic disorders such as schizophrenia. The compounds are also useful to lower IL-4, IL-5, or IL-15 levels in an animal.

公开(公告)号：US10059729B2

公开(公告)日：2018-08-28

申请号：US15306671

申请日：2015-04-24

申请人： Takasago International Corporation

发明人： Osamu Ogata ,  Hideki Nara ,  Yuji Nakayama

IPC分类号： C07F15/00 ,  B01J31/24 ,  B01J31/22 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C29/149 ,  C07C31/20 ,  C07C33/22 ,  C07F9/50 ,  C07C209/18 ,  C07C45/29 ,  C07F19/00 ,  C07C211/48 ,  C07C49/78 ,  C07D213/30 ,  C07B61/00

CPC分类号： C07F15/0046 ,  B01J31/22 ,  B01J31/24 ,  B01J31/2409 ,  B01J2231/643 ,  B01J2231/70 ,  B01J2531/0216 ,  B01J2531/821 ,  C07B61/00 ,  C07C29/132 ,  C07C29/141 ,  C07C29/145 ,  C07C29/149 ,  C07C31/20 ,  C07C33/22 ,  C07C45/29 ,  C07C49/78 ,  C07C209/18 ,  C07C211/48 ,  C07D213/30 ,  C07F9/50 ,  C07F15/00 ,  C07F19/00

摘要： The present invention provides a novel ruthenium complex that is easy to produce and handle and that can be supplied relatively inexpensively, a method for producing this ruthenium complex, a method for producing alcohols and the like using this ruthenium complex as a catalyst, a method for producing carbonyl compounds using this ruthenium complex as a catalyst, and a method for producing N-alkylamine compounds using this ruthenium complex as a catalyst. The present invention pertains to a ruthenium complex represented by general formula (1) RuX1X2(PNP) (NHC)m(Solv)n(1) (in general formula (1), X1 and X2 each independently represent a monovalent anionic monodentate ligand; PNP represents a tridentate aminodiphosphine ligand, NHC represents an N-heterocyclic carbene derived from a nitrogen-containing heterocyclic ring, and Solv represents a coordinating solvent; and m represents an integer from 1 to 3, n represents an integer from 0 to 2, and 1≤m+n≤3.), a method for producing the same, a catalyst including the same, and methods for producing various organic compounds using this catalyst.

公开(公告)号：US09926274B2

公开(公告)日：2018-03-27

申请号：US14329356

申请日：2014-07-11

申请人： Nippon Soda Co., Ltd.

发明人： Yasushi Shibata ,  Tsutomu Imagawa

IPC分类号： C07D251/04 ,  C07D401/06 ,  C07D213/61 ,  C07C211/48 ,  C07D277/20 ,  C07D257/08 ,  C07C211/03 ,  C07C211/62 ,  C07C209/06 ,  C07B43/04 ,  C07D401/14 ,  C08G73/06

CPC分类号： C07D213/61 ,  C07B43/04 ,  C07C209/06 ,  C07C211/03 ,  C07C211/48 ,  C07C211/62 ,  C07D251/04 ,  C07D257/08 ,  C07D277/20 ,  C07D401/06 ,  C07D401/14 ,  C08G73/0627 ,  C08G73/0644

摘要： The present invention provides a process that enables a substituted methylamine compound which is useful as an intermediate for the production of agricultural chemicals and medicines, to be produced easily, with good yield, and at low cost, and also provides a production intermediate thereof. The process comprises a step of reacting a hexamethylenetetraammonium salt compound represented by a formula (I) with a base to obtain an N-methylidene-substituted methylamine oligomer represented by a formula (II) or a mixture of two or more of the oligomers, and a step of hydrolyzing the N-methylidene-substituted methylamine oligomer represented by formula (II) or the mixture of two or more of the oligomers in the presence of an acid. (wherein A represents an organic group, R represents a hydrogen atom, or an organic group, L represents a halogen atom and the like, and n represents an integer of 2 to 20).

公开(公告)号：US09868797B2

公开(公告)日：2018-01-16

申请号：US14907923

申请日：2014-07-29

申请人： SAUDI BASIC INDUSTRIES CORPORATION ,  SABIC GLOBAL TECHNOLOGIES B.V.

发明人： Nedumbamana Sankaran ,  Prashant Sukumar Shinge ,  Sharankumar Shetty ,  Girish Chandra ,  Haif Al-Shammari ,  Abdulaziz Hamad Al-Humydi ,  Edward Joseph Nesakumar

IPC分类号： C07F17/00 ,  C08F4/6592 ,  C08F10/00 ,  C08F4/76 ,  C07C211/48 ,  C07F5/02 ,  C07C211/52 ,  C08F10/02 ,  C08F4/659

CPC分类号： C08F4/76 ,  C07C211/48 ,  C07C211/52 ,  C07C2602/08 ,  C07F5/02 ,  C07F5/025 ,  C07F17/00 ,  C08F4/65908 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/6592 ,  C08F10/02 ,  C08F2420/02

摘要： A metallocene complex according to formula 1 wherein M is a metal selected from lanthanides or transition metals from group 3, 4, 5, or 6, Q is an anionic ligand to M, k is the number of Q groups and equals the valence of M minus 2, X is a cyclic bridging group that is bonded to a carbon atom of the cyclopentadienyl ligand and to nitrogen, Z1, and Z4 are hydrogen or a hydrocarbon radical with 1-20 carbon atoms; adjacent substituents Z2 and Z3 and are connected to form an indenyl or tetrahydroindenyl ring system and R is hydrogen or a hydrocarbon radical with 1-20 carbon atoms. Also described is a composition comprising the metallocene complex, a process for the preparation of the complex, and a process for the polymerization of olefin polymers in the presence of the metallocene complex.

公开(公告)号：US09675565B2

公开(公告)日：2017-06-13

申请号：US13957861

申请日：2013-08-02

申请人： Drexel University ,  Rutgers, The State University of New Jersey

发明人： Sandhya Kortagere ,  Eldo V. Kuzhikandahil

IPC分类号： C07C211/45 ,  C07C211/48 ,  A61K31/137 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/473 ,  A61K31/48 ,  A61K31/506 ,  A61K31/519 ,  C07C211/29 ,  C07C215/08 ,  C07C215/54 ,  C07C217/62 ,  C07D209/14 ,  C07D235/16 ,  C07D471/04 ,  A61K45/06 ,  A61K31/198 ,  A61K31/5513

CPC分类号： A61K31/137 ,  A61K31/198 ,  A61K31/4045 ,  A61K31/4184 ,  A61K31/428 ,  A61K31/473 ,  A61K31/48 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5513 ,  A61K45/06 ,  C07C211/29 ,  C07C215/08 ,  C07C215/54 ,  C07C217/62 ,  C07D209/14 ,  C07D235/16 ,  C07D471/04 ,  A61K2300/00

摘要： The present invention provides a method of inhibiting, suppressing or preventing levodopa-induced dyskinesia in a patient suffering from Parkinson's Disease, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention. The present invention further provides a method of inhibiting, suppressing or preventing Parkinson's Disease in a patient, comprising the step of administering to the patient a pharmaceutical composition comprising at least one compound of the invention.

公开(公告)号：US09650310B2

公开(公告)日：2017-05-16

申请号：US14902704

申请日：2014-06-25

申请人： RHEINISCHE WESTFÄLISCHE TECHNISCHE HOCHSCHULE (RWTH) AACHEN

发明人： Jürgen Klankermayer ,  Kassem Beydoun ,  Thorsten Vom Stein ,  Walter Leitner

IPC分类号： C07C209/08 ,  C07C209/52 ,  C07C209/50 ,  C07C209/66 ,  C07C209/26 ,  C07C213/08 ,  C07C213/02 ,  B01J31/00 ,  C07C211/48 ,  C07C211/52 ,  C07C217/84 ,  C07B43/04 ,  C07D209/08

CPC分类号： C07B43/04 ,  B01J31/00 ,  B01J31/2291 ,  B01J31/24 ,  B01J2231/341 ,  B01J2531/0258 ,  B01J2531/821 ,  C07C209/26 ,  C07C209/50 ,  C07C209/52 ,  C07C209/66 ,  C07C213/02 ,  C07C213/08 ,  C07C2601/14 ,  C07D209/08 ,  C07C211/48 ,  C07C211/52 ,  C07C217/84 ,  C07C211/55

摘要： A method for the methylation of amines, amides and imines comprises the step of reacting these compounds with CO2 and H2 in the presence of a Ruthenium-phosphine complex.

公开(公告)号：US09586883B2

公开(公告)日：2017-03-07

申请号：US14255049

申请日：2014-04-17

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Zachary K. Wickens ,  Bill Morandi ,  Robert H. Grubbs ,  Kacper Skakuj ,  Sarah M. Bronner

IPC分类号： C07C45/34 ,  C07C249/04 ,  C07C253/00 ,  C07C201/12 ,  C07C205/44 ,  C07C209/60 ,  C07C213/00 ,  C07C227/08 ,  C07C51/373 ,  C07C59/235 ,  C07C211/48 ,  C07C217/48 ,  C07D301/22

CPC分类号： C07C45/34 ,  C07C51/373 ,  C07C201/12 ,  C07C205/44 ,  C07C209/60 ,  C07C213/00 ,  C07C227/08 ,  C07C249/04 ,  C07C253/00 ,  C07D301/22 ,  C07C59/235 ,  C07C211/48 ,  C07C217/48 ,  C07C229/18 ,  C07C47/02 ,  C07C47/11 ,  C07C47/14 ,  C07C47/19 ,  C07C47/198 ,  C07C47/277

摘要： This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex; (b) a copper complex; (c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde.

摘要翻译： 本公开涉及制备有机醛的方法，每种方法包括使末端烯烃与氧化混合物接触，所述氧化混合物包含：（a）二氯 - 钯络合物; （b）铜络合物; （c）亚硝酸盐源; 在需氧反应条件下，足以将至少一部分末端烯烃转化为醛。

公开(公告)号：US09502629B2

公开(公告)日：2016-11-22

申请号：US14579576

申请日：2014-12-22

申请人： FUJIFILM Corporation

发明人： Eri Takahashi

IPC分类号： H01L35/24 ,  H01L35/22 ,  H01L35/32 ,  H01L35/34 ,  C08L101/12 ,  C08G75/32 ,  C07C211/48 ,  C08L3/04 ,  B82Y30/00 ,  C08K7/00 ,  C08L65/00 ,  C08L101/00 ,  C08G61/12 ,  C08K7/24 ,  C08K7/06

CPC分类号： H01L35/24 ,  B82Y30/00 ,  C08G61/126 ,  C08G2261/3223 ,  C08G2261/55 ,  C08K3/041 ,  C08K7/00 ,  C08K7/06 ,  C08K7/24 ,  C08L25/06 ,  C08L65/00 ,  C08L101/00 ,  H01L35/22

摘要： In a thermoelectric conversion element comprising a thermoelectric conversion layer formed by using a thermoelectric conversion material, the thermoelectric conversion material includes a polythiophene polymer, which includes a main chain made of a repeating unit represented by the following formula (1), and has a side chain R in a regiorandom array with respect to the main chain, a carbon nanotube, and a non-conjugated macromolecule. In Formula (1), R represents an alkyl group having 1 to 20 carbon atoms.

摘要翻译： 式（1）中，R表示碳原子数1〜20的烷基。

公开(公告)号：US09496509B2

公开(公告)日：2016-11-15

申请号：US14361803

申请日：2012-11-29

申请人： HITACHI CHEMICAL COMPANY, LTD.

发明人： Shigeaki Funyuu ,  Naoki Asano ,  Kenichi Ishitsuka

IPC分类号： C09D11/52 ,  H01L51/00 ,  C08K5/17 ,  C08L101/12 ,  H05B33/02 ,  H05B33/10 ,  C07C211/45 ,  C07C211/48 ,  C09B69/02 ,  C08J7/04 ,  C08K5/55 ,  H01L51/50

CPC分类号： H01L51/0077 ,  C07C211/45 ,  C07C211/48 ,  C08J7/047 ,  C08J2365/00 ,  C08K5/17 ,  C08K5/55 ,  C08L101/12 ,  C09B69/02 ,  C09D11/52 ,  H01L51/0007 ,  H01L51/0035 ,  H01L51/008 ,  H01L51/5056 ,  H01L51/5072 ,  H01L51/5088 ,  H05B33/02 ,  H05B33/10

摘要： Provided is an organic electronic material which is excellent in curability at low temperatures in the case as an ink composition, and able to prepare an organic electronic element capable of reducing the driving voltage and of being driven stably for a long time. The organic electronic material is characterized by containing at least an ionic compound represented by the following general formula (1), and a compound including a charge transporting unit. [In the general formula (1), Ar represents an aryl group or a heteroaryl group, Ra to Rb each independently represent a hydrogen atom (H), an alkyl group, a benzyl group, an aryl group, or a heteroaryl group, and Ar, Ra and Rb may be linked to each other to form a ring. However, at least one of Ra to Rb is any of a hydrogen atom, an alkyl group, and a benzyl group. A represents an anion.]