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公开(公告)号：US20240361307A1
公开(公告)日：2024-10-31
申请号：US18606701
申请日：2024-03-15
Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Omid Farokhzad , Morteza Mahmoudi , Claudia Corbo
IPC: G01N33/543 , C01G49/02 , G01N33/574 , G01N33/68 , G06F18/24 , G06N20/20 , G16B40/20 , B82Y35/00
CPC classification number: G01N33/5432 , C01G49/02 , G01N33/54326 , G01N33/57488 , G01N33/6842 , G01N33/6848 , G06F18/24 , G06N20/20 , G16B40/20 , B82Y35/00 , C01P2004/64 , G06F2218/20
Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
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2.发明公开公开(公告)号：US20240319203A1
公开(公告)日：2024-09-26
申请号：US18579620
申请日：2022-08-04
Applicant: H. LUNDBECK A/S
Inventor： Anne-Marie JACOBSEN , Line Rorbaek OLSEN , Frank SCHALK , Nico van de MERBEL
IPC: G01N33/68
CPC classification number: G01N33/6848 , G01N33/6842 , G01N33/6896 , G01N2800/2821 , G01N2800/52
Abstract: The present invention relates to a method of measuring pS396 Tau in a sample comprising the steps of i-iv, i) Treating a CSF sample from a subject suffering or suspected to be suffering from a Tau pathology with trypsin, ii) Subjecting the sample in step i) to a desphosphorylation agent and subsequently take part of the sample aside for step iv) before proceeding to step iii) with the remaining sample, iii) Subjecting the dephosphorylated sample from step ii) to a second trypsin treatment, iv) Measuring the amount of the Tau peptides (SPVVSGDTSPR) corresponding to Tau residues 396-406 in the samples from step ii) and step iii) using LC-MS.
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公开(公告)号：US20240302381A1
公开(公告)日：2024-09-12
申请号：US18659813
申请日：2024-05-09
Applicant: Encodia, Inc.
Inventor： Mark S. Chee , Kevin L. Gunderson , Michael Phillip Weiner
CPC classification number: G01N33/6824 , C40B40/10 , C40B70/00 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2458/00 , G01N2458/10
Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.
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公开(公告)号：US20240295563A1
公开(公告)日：2024-09-05
申请号：US18659334
申请日：2024-05-09
Applicant: Encodia, Inc.
Inventor： Mark S. Chee , Kevin L. Gunderson , Michael Phillip Weiner
CPC classification number: G01N33/6824 , C40B40/10 , C40B70/00 , G01N33/6803 , G01N33/6842 , G01N33/6845 , G01N2458/00 , G01N2458/10
Abstract: A method for analyzing macromolecules, including peptides, polypeptides, and proteins, employing nucleic acid encoding is disclosed.
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5.发明公开公开(公告)号：US20240280583A1
公开(公告)日：2024-08-22
申请号：US18638970
申请日：2024-04-18
Applicant: Immatics Biotechnologies GmbH
Inventor： Toni WEINSCHENK , Julia LEIBOLD
IPC: G01N33/68 , G01N33/569
CPC classification number: G01N33/6848 , G01N33/56977 , G01N33/6842 , G01N33/6878 , G01N2333/70539 , G01N2458/15 , G01N2496/00 , G01N2560/00 , G01N2570/00
Abstract: The present invention relates to a method for the absolute quantification of naturally processed HLA-restricted cancer peptides, i.e. the determination of the copy number of peptide(s) as presented per cell. The present invention can not only be used for the development of antibody therapies or peptide vaccines, but is also highly valuable for a molecularly defined immuno-monitoring, and useful in the processes of identifying of new peptide antigens for immunotherapeutic strategies, such as respective vaccines, antibody-based therapies or adoptive T-cell transfer approaches in cancer, infectious and/or autoimmune diseases.
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Patent Agency Ranking
公开(公告)号：US20240280566A1
公开(公告)日：2024-08-22
申请号：US18644619
申请日：2024-04-24
Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Omid Farokhzad , Morteza Mahmoudi , Claudia Corbo
IPC: G01N33/543 , B82Y35/00 , C01G49/02 , G01N33/574 , G01N33/68 , G06F18/24 , G06N20/20 , G16B40/20
CPC classification number: G01N33/5432 , C01G49/02 , G01N33/54326 , G01N33/57488 , G01N33/6842 , G01N33/6848 , G06F18/24 , G06N20/20 , G16B40/20 , B82Y35/00 , C01P2004/64 , G06F2218/20
Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
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公开(公告)号：US20240183858A1
公开(公告)日：2024-06-06
申请号：US18510429
申请日：2023-11-15
Applicant: Nautilus Subsidiary, Inc.
Inventor： Hunter Bryan BOYCE , Kara JUNEAU , Torri Elise RINKER , Parag MALLICK
CPC classification number: G01N33/6842 , C07K1/22 , C07K14/001 , G01N33/5308 , G01N2570/00
Abstract: A set of polypeptides including a plurality of different polypeptides, each of the different polypeptides including a non-naturally occurring amino acid sequence, wherein a set of different epitopes occurs in the set of polypeptides, each of the different epitopes occurring in the non-naturally occurring amino acid sequence of a subset of the different polypeptides, and the non-naturally occurring amino acid sequence of each of the different polypeptides including a plurality of different epitopes of the set of epitopes.
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公开(公告)号：US11971404B2
公开(公告)日：2024-04-30
申请号：US18088946
申请日：2022-12-27
Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventor： Omid Farokhzad , Morteza Mahmoudi , Claudia Corbo
IPC: G01N33/543 , C01G49/02 , G01N33/574 , G01N33/68 , G06F18/24 , G06N20/20 , G16B40/20 , B82Y35/00
CPC classification number: G01N33/5432 , C01G49/02 , G01N33/54326 , G01N33/57488 , G01N33/6842 , G01N33/6848 , G06F18/24 , G06N20/20 , G16B40/20 , B82Y35/00 , C01P2004/64 , G06F2218/20
Abstract: The present disclosure provides a system comprising a communication interface and computer for assigning a label to the biomolecule fingerprint, wherein the label corresponds to a biological state. The present disclosure also provides a sensor arrays for detecting biomolecules and methods of use. In some embodiments, the sensor arrays are capable of determining a disease state in a subject.
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公开(公告)号：US20240103006A1
公开(公告)日：2024-03-28
申请号：US18468249
申请日：2023-09-15
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Maksim Fomin , Hannes Kuchelmeister
IPC: G01N33/68 , C07C259/06
CPC classification number: G01N33/6845 , C07C259/06 , G01N33/6842
Abstract: The present invention relates to chemical probes for the improved detection of cysteine in a test sample, preferably an aqueous test sample, as well as respective uses and kits.
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10.发明公开公开(公告)号：US20240069019A1
公开(公告)日：2024-02-29
申请号：US18459711
申请日：2023-09-01
Applicant: Becton, Dickinson and Company
Inventor： Christina Fan , Olaf Zoellner
IPC: G01N33/566 , G16B99/00 , G01N33/50 , G01N33/543 , G01N33/68 , C12Q1/6804 , G16Z99/00 , C12N15/10 , C12Q1/6806 , C12Q1/6823 , C12Q1/6869 , C12Q1/68
CPC classification number: G01N33/566 , G16B99/00 , G01N33/505 , G01N33/54313 , G01N33/6842 , G01N33/6857 , C12Q1/6804 , G16Z99/00 , C12N15/1006 , C12N15/1096 , C12Q1/6806 , C12Q1/6823 , C12Q1/6869 , G01N33/54306 , C12Q1/68 , G16B25/10
Abstract: Some embodiments disclosed herein provide a plurality of compositions each comprising a protein binding reagent conjugated with an oligonucleotide. The oligonucleotide comprises a unique identifier for the protein binding reagent it is conjugated with, and the protein binding reagent is capable of specifically binding to a protein target. Further disclosed are methods and kits for quantitative analysis of a plurality of protein targets in a sample and for simultaneous quantitative analysis of protein and nucleic acid targets in a sample. Also disclosed herein are systems and methods for preparing a labeled biomolecule reagent, including a labeled biomolecule agent comprising a protein binding reagent conjugated with an oligonucleotide.
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