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    METHODS OF SELECTING BINDING REAGENTS
    1.
    发明公开
    METHODS OF SELECTING BINDING REAGENTS 审中-公开

    公开(公告)号：US20240158782A1

    公开(公告)日：2024-05-16

    申请号：US18402273

    申请日：2024-01-02

    Applicant: Nautilus Subsidiary, Inc.

    Inventor： Parag MALLICK

    IPC: C12N15/10 ,  G01N33/68

    CPC classification number: C12N15/1055 ,  G01N33/6845

    Abstract: Methods and systems are provided herein for selecting an affinity reagent which binds a desired peptide epitope in a plurality of sequence contexts. The method relies on obtaining a peptide library, each peptide having the sequence αXβ, wherein X is the desired peptide epitope, wherein each of α and β comprise an amino acid, using the peptide library to select an affinity reagent.

    DECODING APPROACHES FOR PROTEIN IDENTIFICATION
    3.
    发明申请
    DECODING APPROACHES FOR PROTEIN IDENTIFICATION 有权

    公开(公告)号：US20250037789A1

    公开(公告)日：2025-01-30

    申请号：US18916443

    申请日：2024-10-15

    Applicant: Nautilus Subsidiary, Inc.

    Inventor： Sujal M. PATEL ,  Parag MALLICK ,  Jarrett D. EGERTSON

    IPC: G16B5/20 ,  G01N27/26 ,  G01N27/60 ,  G01N27/72

    Abstract: Methods and systems are provided for accurate and efficient identification and quantification of proteins. In an aspect, disclosed herein is a method for identifying a protein in a sample of unknown proteins, comprising receiving information of a plurality of empirical measurements performed on the unknown proteins; comparing the information of empirical measurements against a database comprising a plurality of protein sequences, each protein sequence corresponding to a candidate protein among a plurality of candidate proteins; and for each of one or more of the plurality of candidate proteins, generating a probability that the candidate protein generates the information of empirical measurements, a probability that the plurality of empirical measurements is not observed given that the candidate protein is present in the sample, or a probability that the candidate protein is present in the sample; based on the comparison of the information of empirical measurements against the database.

    SYSTEMS AND METHODS OF VALIDATING NEW AFFINITY REAGENTS
    7.
    发明公开
    SYSTEMS AND METHODS OF VALIDATING NEW AFFINITY REAGENTS 审中-公开

    公开(公告)号：US20240087679A1

    公开(公告)日：2024-03-14

    申请号：US18463100

    申请日：2023-09-07

    Applicant: NAUTILUS SUBSIDIARY, INC.

    Inventor： Jarrett D. EGERTSON ,  Parag MALLICK

    IPC: G16B20/30 ,  C12Q1/6834

    CPC classification number: G16B20/30 ,  C12Q1/6834

    Abstract: Disclosed are systems and methods for identifying the binding characteristics of a partially characterized or completely unknown affinity reagent, such as an antibody or aptamer, by binding that affinity reagent against an array of known proteins. The proteins on the array which bind to the partially characterized or completely unknown affinity reagent are then determined and an analysis performed to determine the binding characteristics of the affinity reagent.

    SYSTEMS AND METHODS FOR ASSESSING AND IMPROVING THE QUALITY OF MULTIPLEX MOLECULAR ASSAYS
    9.
    发明公开
    SYSTEMS AND METHODS FOR ASSESSING AND IMPROVING THE QUALITY OF MULTIPLEX MOLECULAR ASSAYS 审中-公开

    公开(公告)号：US20230360732A1

    公开(公告)日：2023-11-09

    申请号：US18301891

    申请日：2023-04-17

    Applicant: Nautilus Subsidiary, Inc.

    Inventor： Jarrett D. EGERTSON ,  James SHERMAN ,  Vadim LOBANOV ,  Parag MALLICK ,  James Henry JOLY

    IPC: G16B30/10 ,  G16B40/00 ,  G16B50/30

    CPC classification number: G16B30/10 ,  G16B40/00 ,  G16B50/30

    Abstract: A method of identifying extant proteins, including (a) inputting to a computer processor: (i) a plurality of empirical binding profiles, individual empirical binding profiles including empirical binding outcomes for binding of an extant protein to a plurality of different affinity reagents, (ii) a plurality of candidate outcome profiles, individual candidate outcome profiles including binding outcomes for binding of a candidate protein to the plurality of different affinity reagents, and (iii) a plurality of pseudo outcome profiles, individual pseudo outcome profiles including a rearrangement of a candidate outcome profile; (b) performing a process in the computer processor to identify extant proteins based on the empirical binding profiles of the extant proteins and the plurality of candidate outcome profiles; and (c) performing a process in the computer processor to determine a false discovery statistic for the extant proteins based on the plurality of pseudo outcome profiles.

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