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1.发明申请公开(公告)号：US20150166956A1
公开(公告)日：2015-06-18
申请号：US14167393
申请日：2014-01-29
Applicant: General Electric Company
Inventor： Christopher Michael Puleo , Erik Leeming Kvam , Gregory Andrew Grossmann , Craig Patrick Galligan , Jason Michael Nichols , Xuefeng Wang , Jason Louis Davis
IPC: C12N5/078
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A device is configured for separation of particulates dispersed within a base fluid, wherein the particulates have a relative density difference compared to the base fluid. The device comprises a microchannel of length l and height h comprising an inlet and an outlet; a microporous surface on one or more walls of the microchannel; a collection chamber on an opposing side of the microporous surface; and an applied force field across the height h of the microchannel to sediment the particles through the microporous surface into the collection chamber. The microporous body operationally generates a fluid flow regime comprising a first fluid flow having a first flow rate through the microchannel and a second fluid flow having a second flow rate through the collection chamber and the second flow rate is a fraction of the first flow rate.
Abstract translation: 一种装置被配置用于分离分散在基础流体中的微粒，其中所述颗粒与基础流体相比具有相对密度差。 该装置包括长度为l的微通道和包括入口和出口的高度h; 在微通道的一个或多个壁上的微孔表面; 在微孔表面的相对侧上的收集室; 以及穿过微通道的高度h的施加的力场，以将颗粒通过微孔表面沉淀到收集室中。 微孔体可操作地产生流体流动状态，其包括具有通过微通道的第一流量的第一流体流和具有通过收集室的第二流速的第二流体流，第二流量是第一流量的一部分。
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公开(公告)号：US08981069B2
公开(公告)日：2015-03-17
申请号：US13721948
申请日：2012-12-20
Applicant: General Electric Company
Inventor： Brian Christopher Bales , Erik Leeming Kvam , Jason Louis Davis
Abstract: The present disclosure generally relates to dry solid matrices for the extraction, stabilization, and storage of nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the nucleic acids stored in the dry solid matrix are also described.
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公开(公告)号：US09616361B2
公开(公告)日：2017-04-11
申请号：US14243469
申请日：2014-04-02
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Jason Louis Davis , Jason M. Nichols
IPC: B01D21/02 , B01D21/24 , B01D21/28 , C02F1/24 , C02F1/48 , B01D21/00 , C02F1/00 , C12M1/00 , C12N5/078 , B01L3/00 , B01D17/02 , C02F103/08 , C02F103/10 , C02F1/44 , C02F101/32
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A system is provided for separating particulates dispersed within a base fluid wherein at least one of the particulates and the base fluid is an organic liquid. The system relies on a microfluidic separation device comprising a microchannel in fluid communication across a microporous body with a collection chamber. Particulates and a portion of the base fluid traverse the microporous body under the influence of an external force field and are collected in the collection chamber. A first fluid flow having a first flow rate through the microchannel together with the microporous body operationally generate a second fluid flow within the collection chamber as base fluid and particulates traverse the microporous body and enter the collection chamber, and as base fluid re-traverses the microporous body and re-enters the microchannel, the second fluid flow having a flow rate which is a fraction of the first flow rate.
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公开(公告)号：US20150265977A1
公开(公告)日：2015-09-24
申请号：US14221892
申请日：2014-03-21
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Louisa Ruth Carr , Hongchen Dong , Paul Michael Smigelski, JR. , Jason Louis Davis , Jason Michael Nichols
CPC classification number: B01D71/70 , B01D67/0088 , B01D69/10 , B01D69/12 , B01D71/36 , B01D2323/26 , B01D2323/30 , C02F1/444 , C02F2101/32
Abstract: Methods for treating water containing dissolved solids, suspended solids, organic material, or combinations include contacting the water with a coated membrane comprising a coating material disposed on a membrane substrate, the coating material comprising structural units derived from a compound of formula I, a compound of formula II and a compound of formula III; wherein R1, R2, and R3 are, independently at each occurrence, C1-C12 alkyl; R4 is alkylsilyl; L1 is alkylurethanyl; L2 and L3 are, independently at each occurrence, alkyl; X is hydroxy, alkoxy, or alkylamino; and m, n, and p, independently at each occurrence, range between 4 and 9. The coated membrane is joined to a backing in membrane filtration apparatuses for use in the methods.
Abstract translation: 用于处理含有溶解的固体，悬浮固体，有机材料或组合的水的方法包括使水与包含设置在膜基材上的涂料的涂布膜接触，所述涂料包含衍生自式I化合物的结构单元，化合物 的式II化合物和式III化合物; 其中R 1，R 2和R 3在每次出现时独立地为C 1 -C 12烷基; R4是烷基甲硅烷基; L1是烷基氨基甲酸酯; L2和L3各自独立地为烷基; X是羟基，烷氧基或烷基氨基; m，n和p各自独立地在4和9之间。涂覆的膜与用于该方法的膜过滤装置中的背衬接合。
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公开(公告)号：US20130289257A1
公开(公告)日：2013-10-31
申请号：US13721948
申请日：2012-12-20
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Brian Christopher Bales , Erik Leeming Kvam , Jason Louis Davis
IPC: B01J20/04
CPC classification number: B01J20/045 , B01J20/24 , C12N15/1006 , C12N15/1017 , G01N1/40
Abstract: The present disclosure generally relates to dry solid matrices for the extraction, stabilization, and storage of nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the nucleic acids stored in the dry solid matrix are also described.
Abstract translation: 本公开内容通常涉及用于在环境条件下长时间提取，稳定和储存核酸，特别是RNA的干固体基质。 还描述了收集和回收存储在干燥固体基质中的核酸的方法。
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Patent Agency Ranking
公开(公告)号：US09534214B2
公开(公告)日：2017-01-03
申请号：US14068633
申请日：2013-10-31
Applicant: General Electric Company
Inventor： Bing Li , Gregory Andrew Grossmann , Erik Leeming Kvam , Brian Christopher Bales , Jason Louis Davis
CPC classification number: C12N15/1006 , B01J20/22 , B01J20/261 , B01J20/321 , B01J20/3212 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3274 , C12N15/1017
Abstract: A solid substrate for biological sample storage under dry-state and elution of biomolecules is provided. The dry, solid substrate is coated with saccharides, such as monosaccharides, oligosaccharides, polysaccharides or combinations thereof, and the substrate is comprised of one or more protein denaturing agents impregnated therein under a substantially dry state. A method for elution of biomolecules from biological samples is also provided. The compositions disclosed herein provide for enhanced elution and recovery of biomolecules, such as nucleic acids, from the sample. The sample is disposed on a substrate, dried to a substantially dry state; eluted from the biological sample dried on the substrate by rehydrating the substrate in an elution buffer.
Abstract translation: 提供了一种在干态下生物样品储存和生物分子洗脱的固体底物。 干燥的固体底物涂覆有糖，例如单糖，寡糖，多糖或其组合，并且底物由一种或多种在基本干燥状态下浸渍的蛋白质变性剂组成。 还提供了用于从生物样品中洗脱生物分子的方法。 本文公开的组合物提供来自样品的生物分子（例如核酸）的增强的洗脱和回收。 将样品置于基材上，干燥至基本干燥状态; 通过在洗脱缓冲液中再水化底物，从在底物上干燥的生物样品中洗脱。
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公开(公告)号：US20150165347A1
公开(公告)日：2015-06-18
申请号：US14563334
申请日：2014-12-08
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Jason Michael Nichols , Christopher Michael Puleo , Jason Louis Davis , Daniel George Norton , Craig Patrick Galligan , Rachel Marie Gettings
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A microclarification system is disclosed which can be used to separate solid particulates dispersed within a base fluid such as water. The microclarification system includes a plurality of microfluidic separator units disposed between and in fluid communication with a fluid inlet manifold and a fluid outlet manifold. The microclarification system enforces lamellar flow of fluid though it and as a result the rate at which particles settle is enhanced within a collection chamber associated with each microfluidic separator unit and through which the fluid being purified must pass. Each microfluidic separator unit includes a microfluidic outlet microchannel disposed between the microfluidic collection chamber and the fluid outlet manifold, and a gas-liquid flushing module configured to purge particulates from the collection chamber during a collection chamber purge cycle. Optionally, each microfluidic separator unit may include a microfluidic inlet microchannel. The system holds promise in municipal water purification among other applications.
Abstract translation: 公开了一种微分离系统，其可用于分离分散在基础流体例如水中的固体颗粒。 微型澄清系统包括多个微流体分离器单元，其设置在流体入口歧管和流体出口歧管之间并与其流体连通。 微量澄清系统执行流体的层状流动，结果，在与每个微流体分离器单元相关联的收集室内增强颗粒沉降的速率，并且净化的流体必须通过该速率。 每个微流体分离器单元包括设置在微流体收集室和流体出口歧管之间的微流体出口微通道，以及构造成在收集室清洗循环期间从收集室中清除微粒的气液冲洗模块。 任选地，每个微流体分离器单元可以包括微流体入口微通道。 该系统在城市净水中的应用前景广阔。
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8.发明申请公开(公告)号：US20150165346A1
公开(公告)日：2015-06-18
申请号：US14243469
申请日：2014-04-02
Applicant: GENERAL ELECTRIC COMPANY
Inventor： Christopher Michael Puleo , Jason Louis Davis , Jason M. Nichols
CPC classification number: B01D21/0087 , B01D17/02 , B01D21/0006 , B01D21/0042 , B01D21/02 , B01D21/10 , B01D21/2433 , B01D21/2444 , B01D21/245 , B01D2221/04 , B01L3/502753 , B01L3/502761 , B01L2200/0631 , B01L2200/0652 , B01L2200/0668 , B01L2300/0681 , B01L2300/0851 , B01L2400/0421 , B01L2400/043 , B01L2400/0457 , B01L2400/0469 , C02F1/00 , C02F1/24 , C02F1/444 , C02F1/48 , C02F2001/007 , C02F2101/32 , C02F2103/08 , C02F2103/10 , C02F2201/002 , C12M47/02 , C12N5/0641
Abstract: A system is provided for separating particulates dispersed within a base fluid wherein at least one of the particulates and the base fluid is an organic liquid. The system relies on a microfluidic separation device comprising a microchannel in fluid communication across a microporous body with a collection chamber. Particulates and a portion of the base fluid traverse the microporous body under the influence of an external force field and are collected in the collection chamber. A first fluid flow having a first flow rate through the microchannel together with the microporous body operationally generate a second fluid flow within the collection chamber as base fluid and particulates traverse the microporous body and enter the collection chamber, and as base fluid re-traverses the microporous body and re-enters the microchannel, the second fluid flow having a flow rate which is a fraction of the first flow rate.
Abstract translation: 提供一种用于分离分散在基础流体中的微粒的系统，其中至少一个微粒和基础流体是有机液体。 该系统依赖于微流体分离装置，其包括跨越微孔体与收集室流体连通的微通道。 基体液体的一部分在外力场的影响下穿过微孔体并被收集在收集室中。 具有与微孔体一起通过微通道的第一流速的第一流体流动可操作地在收集室内产生作为基础流体的第二流体流，并且微粒穿过微孔体并进入收集室，并且当基础流体重新穿过 微孔体并重新进入微通道，第二流体流的流速是第一流量的一部分。
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公开(公告)号：US09040675B2
公开(公告)日：2015-05-26
申请号：US13721948
申请日：2012-12-20
Applicant: General Electric Company
Inventor： Brian Christopher Bales , Erik Leeming Kvam , Jason Louis Davis
CPC classification number: B01J20/045 , B01J20/24 , C12N15/1006 , C12N15/1017 , G01N1/40
Abstract: The present disclosure generally relates to dry solid matrices for the extraction, stabilization, and storage of nucleic acids, particularly RNA, in a dry format under ambient conditions for a prolonged period of time. Methods for collecting and recovering the nucleic acids stored in the dry solid matrix are also described.
Abstract translation: 本公开内容通常涉及用于在环境条件下长时间提取，稳定和储存核酸，特别是RNA的干固体基质。 还描述了收集和回收存储在干燥固体基质中的核酸的方法。
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公开(公告)号：US20150119566A1
公开(公告)日：2015-04-30
申请号：US14068633
申请日：2013-10-31
Applicant: General Electric Company
Inventor： Bing Li , Gregory Andrew Grossmann , Erik Leeming Kvam , Brian Christopher Bales , Jason Louis Davis
CPC classification number: C12N15/1006 , B01J20/22 , B01J20/261 , B01J20/321 , B01J20/3212 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J20/3274 , C12N15/1017
Abstract: A solid substrate for biological sample storage under dry-state and elution of biomolecules is provided. The dry, solid substrate is coated with saccharides, such as monosaccharides, oligosaccharides, polysaccharides or combinations thereof, and the substrate is comprised of one or more protein denaturing agents impregnated therein under a substantially dry state. A method for elution of biomolecules from biological samples is also provided. The compositions disclosed herein provide for enhanced elution and recovery of biomolecules, such as nucleic acids, from the sample. The sample is disposed on a substrate, dried to a substantially dry state; eluted from the biological sample dried on the substrate by rehydrating the substrate in an elution buffer.
Abstract translation: 提供了一种在干态下生物样品储存和生物分子洗脱的固体底物。 干燥的固体底物涂覆有糖，例如单糖，寡糖，多糖或其组合，并且底物由一种或多种在基本干燥状态下浸渍的蛋白质变性剂组成。 还提供了用于从生物样品中洗脱生物分子的方法。 本文公开的组合物提供来自样品的生物分子（例如核酸）的增强的洗脱和回收。 将样品置于基材上，干燥至基本干燥状态; 通过在洗脱缓冲液中再水化底物，从在底物上干燥的生物样品中洗脱。
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