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    METHODS AND COMPOSITIONS FOR THE TREATMENT AND/OR PROPHYLAXIS OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE
    4.
    发明申请
    METHODS AND COMPOSITIONS FOR THE TREATMENT AND/OR PROPHYLAXIS OF CLOSTRIDIUM DIFFICILE ASSOCIATED DISEASE 审中-公开
    治疗和/或预防性关节炎相关疾病的方法和组合物

    公开(公告)号：US20160083457A1

    公开(公告)日：2016-03-24

    申请号：US14785527

    申请日：2014-04-17

    申请人： IMMURON LIMITED

    发明人： Dena LYRAS ,  Melanie HUTTON ,  Bliss CUNNINGHAM ,  Lucy LI ,  Glen CARTER ,  Julian ROOD

    IPC分类号： C07K16/12 ,  A61K39/40 ,  A61K9/00 ,  C07K16/04

    CPC分类号： C07K16/1282 ,  A61K9/0053 ,  A61K39/40 ,  A61K2039/505 ,  A61K2039/522 ,  C07K16/04 ,  C07K2317/12 ,  C07K2317/76

    摘要： The present invention relates to methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease (CD AD). In particular, the invention relates to antibodies that bind to C. difficile antigens and are capable of inhibiting C. difficile infection, at least one symptom of C. difficile associated disease, shedding of C. difficile, and C. difficile associated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to a C. difficile Toxin B; and mammalian or avian antibodies that bind to a C. difficile vegetative cell antigen and/or a C. difficile endospore antigen.

    摘要翻译： 本发明涉及用于治疗和/或预防艰难梭菌相关疾病（CD AD）的方法和组合物。 特别地，本发明涉及结合艰难梭菌抗原并能够抑制艰难梭菌感染，艰难梭菌相关疾病的至少一种症状，艰难梭菌切除和艰难梭菌相关死亡率的抗体。 本申请的组合物包含：与艰难梭菌毒素B结合的哺乳动物或禽类抗体; 以及结合艰难梭菌营养细胞抗原和/或艰难梭菌内孢子抗原的哺乳动物或禽抗体。

    Antibody production in farm animals
    5.
    发明授权
    Antibody production in farm animals 有权

    公开(公告)号：US06974573B2

    公开(公告)日：2005-12-13

    申请号：US09845036

    申请日：2001-04-27

    申请人： Sang He Lee

    发明人： Sang He Lee

    IPC分类号： C07K16/04 ,  C07K16/12 ,  A61K39/00

    CPC分类号： A61K39/08 ,  A61K39/107 ,  A61K2039/505 ,  A61K2039/541 ,  A61K2039/552 ,  C07K16/04 ,  C07K16/1282

    摘要： The present invention provides means and methods for obtaining an antibody in a mammary secretion product of a farm-animal comprising administering to said animal at least two compositions, which may be the same or different, comprising an antigen to which said antibody is to be raised, the method comprising administering at least a first of said compositions such that a high mucosal and/or systemic immune response is obtained and wherein at least a second of said compositions is administered to a mammary gland and/or a supramammary lymph node of said animal.

    Immune suppressive product
    8.
    发明授权
    Immune suppressive product 失效
    免疫抑制产品

    公开(公告)号：US6054124A

    公开(公告)日：2000-04-25

    申请号：US815630

    申请日：1991-12-30

    申请人： Lee R. Beck ,  Ralph J. Stolle

    发明人： Lee R. Beck ,  Ralph J. Stolle

    IPC分类号： A23C9/20 ,  A23L15/00 ,  A24B15/30 ,  A61K35/20 ,  A61K35/54 ,  A61K38/00 ,  A61P37/06 ,  A61P37/08 ,  C07K2/00 ,  C07K14/47 ,  C07K16/02 ,  C07K16/04 ,  C07K16/12 ,  A61K39/00 ,  A23J1/00

    CPC分类号： A61K35/20 ,  A23C9/20 ,  A23L15/00 ,  A24B15/30 ,  C07K14/47 ,  C07K16/02 ,  C07K16/04 ,  C07K16/1282 ,  C07K2/00 ,  C07K2317/11

    摘要： An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens. Said factor(s), however, are highly effective in preventing or alleviating allergic reactions.

    摘要翻译： 通过将过敏原或过敏原的混合物注射到产奶物质的体内制备的免疫抑制产物。 所述产品是从变应原处理的宿主获得的乳或多余的牛奶分馏。 免疫抑制产物是乳和/或其中含有多肽部分，其表面上没有用于治疗宿主的完整过敏原或过敏原。 免疫抑制因子是用于治疗的变应原的次级分。 从完整的过敏原制备免疫抑制性多肽的方法，其涉及将特异的完整过敏原注射到产乳物种中，从处理的宿主的乳中收集完整过敏原的免疫抑制多肽部分。 含有所述多肽部分的免疫抑制乳和/或从所述牛奶获得的多肽部分在动物和人中作为变应原是非反应性的。 然而，所述因子在预防或减轻过敏反应方面是非常有效的。