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    Prevention and treatment of rheumatioid arthritis
    1.
    再颁专利
    Prevention and treatment of rheumatioid arthritis 失效
    预防和治疗风湿性关节炎

    公开(公告)号：USRE33565E

    公开(公告)日：1991-04-02

    申请号：US231219

    申请日：1988-08-11

    申请人： Ralph J. Stolle ,  Lee R. Beck

    发明人： Ralph J. Stolle ,  Lee R. Beck

    IPC分类号： A61K38/00 ,  A61K39/395

    CPC分类号： A61K39/39508 ,  A61K38/00

    摘要： There is disclosed a novel method and product for the treatment and prevention of rheumatoid arthritis. The method involves passive immunization against a mixed spectrum of infectious bacteria which reside in the human gastrointestinal tract. The passive immunization is accomplished by oral.[.injestion.]. .Iadd.ingestion .Iaddend.of IgG immunoglobulin obtained from the milk of cows that have been immunized against a specific spectrum of bacterial types. A unique combination of bacterial species is formulated into a vaccine which is used to immunize dairy cattle. The IgG antibody obtained from the milk of the immunized cows constitutes the product of the invention.

    Anti-cholesterolemic egg, vaccine and method for production, and use
    6.
    发明授权
    Anti-cholesterolemic egg, vaccine and method for production, and use 失效
    抗胆固醇血蛋，疫苗及生产方法及用途

    公开(公告)号：US5215746A

    公开(公告)日：1993-06-01

    申请号：US655815

    申请日：1991-02-15

    申请人： Ralph J. Stolle ,  Lee R. Beck

    发明人： Ralph J. Stolle ,  Lee R. Beck

    IPC分类号： A23C9/20 ,  A24B15/30 ,  A61K35/20 ,  A61K35/54 ,  A61K35/57 ,  A61K38/00 ,  C07K16/02 ,  C07K16/04

    CPC分类号： C07K16/02 ,  A23C9/20 ,  A24B15/30 ,  A61K35/57 ,  C07K16/04 ,  C07K2317/11 ,  Y10S424/803

    摘要： Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterolemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.

    摘要翻译： 公开了抗胆固醇血症卵，所述卵从针对至少一种抗胆固醇血症抗原超免疫的动物获得。 公开了产生所述抗胆固醇血清蛋的疫苗，所述疫苗包含至少一种抗胆固醇血症抗原。 此外，公开了一种不提高血清脂质浓度的人类和其他动物的膳食补充剂，所述补充剂包含抗胆固醇血蛋白或其级分。 还公开了一种治疗人类和其它动物血管疾病的方法，其包括向所述受试者施用足以产生抗动脉硬化作用，抗老化血管作用和/或血清脂质的时间和量 - 下降的效果。

    Immune suppressive product
    8.
    发明授权
    Immune suppressive product 失效

    公开(公告)号：US5814345A

    公开(公告)日：1998-09-29

    申请号：US460277

    申请日：1995-06-21

    申请人： Lee R. Beck ,  Ralph J. Stolle

    发明人： Lee R. Beck ,  Ralph J. Stolle

    IPC分类号： A23C9/142 ,  A61K35/20 ,  A61K35/54

    CPC分类号： A23C9/1422 ,  A61K35/20 ,  C07K2317/11 ,  Y10S530/832 ,  Y10S530/868

    摘要： An immune suppressive product prepared by injecting an allergen or a mixture of allergens into the body of milk-producing species. Said product being the milk or a polypeptide subfraction of milk obtained from the allergen treated host. The immune suppressive product(s) is milk and or the polypeptide fractions contained therein, which is ostensively free of the intact allergen or allergens used for the treatment of the host. The immune suppressive factor(s) being a subfraction of the allergen used for the treatment. A method of preparing immune suppressive polypeptides from intact allergens, which involves injection of the specific intact allergens into a milk-producing species, collecting the immune suppressive polypeptide fractions of the intact allergens from the milk of the treated host. The immune suppressive milk containing said polypeptide fractions, and/or the polypeptide fractions obtained from said milk, are nonreactive in animals and humans as allergens. Said factor(s), however, are highly effective in preventing or alleviating allergic reactions.

    Anti-cholesterolemic egg, vaccine and method for production, and use
    9.
    发明授权
    Anti-cholesterolemic egg, vaccine and method for production, and use 失效
    抗胆固醇血蛋，疫苗及生产方法及用途

    公开(公告)号：US5753268A

    公开(公告)日：1998-05-19

    申请号：US655812

    申请日：1991-02-15

    申请人： Ralph J. Stolle ,  Lee R. Beck

    发明人： Ralph J. Stolle ,  Lee R. Beck

    IPC分类号： A23C9/20 ,  A23L15/00 ,  A24B15/30 ,  A61K35/20 ,  A61K35/54 ,  A61K35/57 ,  A61K38/00 ,  C07K16/02 ,  C07K16/04

    CPC分类号： A23C9/20 ,  A23L15/00 ,  A24B15/30 ,  A61K35/20 ,  A61K35/57 ,  C07K16/02 ,  C07K16/04 ,  C07K2317/11

    摘要： Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterblemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid, concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.

    摘要翻译： 公开了抗胆固醇血症卵，所述卵从针对至少一种抗胆固醇血症抗原超免疫的动物获得。 公开了产生所述抗胆囊细胞蛋的疫苗，所述疫苗包含至少一种抗胆固醇血症抗原。 此外，公开了不提高血清脂质浓度的人类和其它动物的膳食补充剂，所述补充物包含抗胆固醇血症卵或其级分。 还公开了一种治疗人类和其它动物血管疾病的方法，其包括向所述受试者施用足以产生抗动脉硬化作用，抗老化血管作用和/或血清脂质的时间和量 - 下降的效果。

    Anti-cholesterolemic vaccine
    10.
    发明授权
    Anti-cholesterolemic vaccine 失效
    抗胆固醇血症疫苗

    公开(公告)号：US5538727A

    公开(公告)日：1996-07-23

    申请号：US896876

    申请日：1992-06-10

    申请人： Ralph J. Stolle ,  Lee R. Beck

    发明人： Ralph J. Stolle ,  Lee R. Beck

    IPC分类号： A23C9/20 ,  A23L15/00 ,  A24B15/30 ,  A61K35/20 ,  A61K35/54 ,  A61K35/57 ,  A61K38/00 ,  C07K16/02 ,  C07K16/04 ,  A61K39/02 ,  A61K39/116 ,  A61K39/112 ,  A01N63/00

    CPC分类号： A23C9/20 ,  A23L15/00 ,  A24B15/30 ,  A61K35/20 ,  A61K35/57 ,  C07K16/02 ,  C07K16/04 ,  C07K2317/11

    摘要： Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterolemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.

    摘要翻译： 公开了抗胆固醇血症卵，所述卵从针对至少一种抗胆固醇血症抗原超免疫的动物获得。 公开了产生所述抗胆固醇血清蛋的疫苗，所述疫苗包含至少一种抗胆固醇血症抗原。 此外，公开了一种不提高血清脂质浓度的人类和其他动物的膳食补充剂，所述补充剂包含抗胆固醇血蛋白或其级分。 还公开了一种治疗人类和其它动物血管疾病的方法，其包括向所述受试者施用足以产生抗动脉硬化作用，抗老化血管作用和/或血清脂质的时间和量 - 下降的效果。