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    High molecular weight major outer membrane protein of moraxella
    4.
    发明授权
    High molecular weight major outer membrane protein of moraxella 失效
    moraxella的高分子量主要外膜蛋白

    公开(公告)号：US06448386B2

    公开(公告)日：2002-09-10

    申请号：US08945567

    申请日：1998-03-19

    申请人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Pele Chong ,  Michel H. Klein

    发明人： Ken Sasaki ,  Robin E. Harkness ,  Sheena M. Loosmore ,  Pele Chong ,  Michel H. Klein

    IPC分类号： C07H2102

    CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  C12N2799/022 ,  C12N2799/023 ,  Y02A50/466 ,  Y10S424/803

    摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

    摘要翻译： 提供分离和纯化的具有约200kDa分子量的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白。 大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外部细菌病原体引起的疾病的保护 产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。

    HIGH MOLECULAR WEIGHT MAJOR OUTER MEMBRANE PROTEIN OF MORAXELLA
    5.
    发明申请
    HIGH MOLECULAR WEIGHT MAJOR OUTER MEMBRANE PROTEIN OF MORAXELLA 失效
    高分子量主要外膜蛋白质MORAXELLA

    公开(公告)号：US20010014672A1

    公开(公告)日：2001-08-16

    申请号：US08945567

    申请日：1998-03-19

    发明人： KEN SASAKI ,  ROBIN E. HARKNESS ,  SHEENA M. LOOSMORE ,  PELE CHONG ,  MICHEL H. KLEIN

    IPC分类号： A61K031/665 ,  A01N057/00 ,  C07K001/00 ,  C07K014/00 ,  C07K017/00

    CPC分类号： C07K14/212 ,  A61K39/00 ,  A61K2039/53 ,  C07K2319/02 ,  C12N2799/022 ,  C12N2799/023 ,  Y02A50/466 ,  Y10S424/803

    摘要： An isolated and purified outer membrane protein of a Moraxella strain, particularly M. catarrhalis, having a molecular mass of about 200 kDa, is provided. The about 200 kDa outer membrane protein as well as nucleic acid molecules encoding the same are useful in diagnostic applications and immunogenic compositions, particularly for in vivo administration to a host to confer protection against disease caused by a bacterial pathogen that produces the about 200 kDa outer membrane protein or produces a protein capable of inducing antibodies in a host specifically reactive with the about 200 kDa outer membrane protein.

    摘要翻译： 提供分离和纯化的具有约200kDa分子量的莫拉氏菌属菌株，特别是卡他莫拉氏菌的外膜蛋白。 大约200kDa的外膜蛋白以及编码它们的核酸分子可用于诊断应用和免疫原性组合物，特别是用于体内施用于宿主以赋予产生约200kDa外部细菌病原体引起的疾病的保护 产生能够在与约200kDa外膜蛋白特异性反应的宿主中诱导抗体的蛋白质。

    Method for the production of anti-escherichia. coli O157 : H7 antibody
    6.
    发明授权
    Method for the production of anti-escherichia. coli O157 : H7 antibody 有权
    生产抗埃希氏杆菌的方法。 大肠杆菌O157：H7抗体

    公开(公告)号：US6162441A

    公开(公告)日：2000-12-19

    申请号：US461919

    申请日：1999-12-15

    申请人： Hyun-Seok Chae ,  Dong-Woon Kim ,  Chong-Nam Ahn ,  Sung-Geun Cho ,  Jeong-Seok Sim ,  Yong-Gon Kim

    发明人： Hyun-Seok Chae ,  Dong-Woon Kim ,  Chong-Nam Ahn ,  Sung-Geun Cho ,  Jeong-Seok Sim ,  Yong-Gon Kim

    IPC分类号： C07K16/12 ,  A61K39/09 ,  A61K39/40 ,  B28B17/00 ,  C07K16/00

    CPC分类号： C07K16/1232 ,  C07K2317/11 ,  Y10S424/803 ,  Y10S530/853

    摘要： Disclosed is a method for producing anti-E. coli O157 antibodies. Anti-E. coli O157:H7 antibodies are produced in egg-laying hens and isolated from the eggs. E. coli O157:H7 is cultured in a brain heart infusion broth and killed by the treatment with hot water for 5-10 min. After being collected by centrifugation, the dead bacteria is homogenized. Serving as an antigenic material, the bacterial homogenate is injected into egg-laying hens to induce antibodies against E. coli O157:H7 in the eggs. The induced antibodies are isolated from the yolk of the eggs and the eggs containing the antibodies against E. coli O157:H7 can be utilized, in their entirety, for foods. Alternatively, the yolks are separated from the eggs and freeze-dried. The resulting dried egg component can be applied to processed foodstuffs, alone or in combination with whole eggs. Since the antibodies against E. coli O157:H7 are contained in frozen eggs, it is very convenient to store the antibodies. The storage in the frozen eggs also makes it possible to apply the antibodies to almost all foods at any time.

    摘要翻译： 公开了生产抗E的方法。 大肠杆菌O157抗体。 反E。 大肠杆菌O157：H7抗体在产卵母鸡中产生并从卵中分离出来。 大肠杆菌O157：H7在脑心脏输液肉汤中培养，用热水处理5-10分钟杀死。 通过离心收集后，将死菌均质化。 作为抗原材料，将细菌匀浆注入产蛋鸡，以诱导鸡蛋中大肠杆菌O157：H7的抗体。 诱导的抗体从卵的蛋黄中分离出来，含有针对大肠杆菌O157：H7的抗体的卵可以全部用于食物。 或者，将蛋黄与鸡蛋分离并冷冻干燥。 所得干蛋成分可以单独使用或与全蛋结合使用于加工食品。 由于针对大肠杆菌O157：H7的抗体包含在冷冻卵中，所以存储抗体非常方便。 冷冻蛋中的储存也使得可以随时将抗体应用于几乎所有的食物。

    Monoclonal antibodies reactive with endotoxin core
    7.
    发明授权
    Monoclonal antibodies reactive with endotoxin core 失效
    与内毒素核心反应的单克隆抗体

    公开(公告)号：US5057598A

    公开(公告)日：1991-10-15

    申请号：US304884

    申请日：1989-02-01

    申请人： Matthew Pollack ,  Kenneth W. Hunter

    发明人： Matthew Pollack ,  Kenneth W. Hunter

    IPC分类号： A61K38/00 ,  C07K16/12 ,  G01N33/569

    CPC分类号： C07K16/1203 ,  G01N33/56911 ,  A61K38/00 ,  G01N2400/50 ,  Y10S424/803 ,  Y10S530/806 ,  Y10S530/808 ,  Y10S530/825

    摘要： Novel monoclonal antibodies are disclosed, the production of which is specified by particular genes contained, conveniently, in biologically pure cultures of self-reproducing carrier cells, such as, but not limited to, ATCC HB 8297 and ATCC HB 8298, such antibodies being reactive with at least part of endotoxin core of Gram-negative bacteria. Processes of prepaU.S. GOVERNMENT RIGHTSThe invention described herein may be manufactured, used and licensed by or for the U.S. Government for governmental purposes only without the payment to the inventors of any royalties thereon.

    摘要翻译： 公开了新的单克隆抗体，其生产由特定的基因所指定，方便地在自我繁殖载体细胞的生物纯纯培养物中包括但不限于ATCC HB 8297和ATCC HB 8298，所述抗体是反应性的 至少部分革兰氏阴性细菌的内毒素核心。 公开了制备自体繁殖载体细胞的方法，例如ATCC HB 8297和ATCC HB 8298。 还公开了从载体细胞制备抗体的方法，其方便地是细胞系如杂交瘤。 进一步公开的是使用这种抗体的免疫诊断和免疫检测组合物和方法。 还进一步公开了使用抗体的免疫预防和免疫治疗组合物和方法。 还公开了使用抗体的研究组合物和方法。 并且甚至进一步公开了利用该抗体的组合物和方法，其可用于从含有它的溶液或混合物中纯化或除去内毒素。

    Vaccine against Gram-negative bacterial infections
    8.
    发明授权
    Vaccine against Gram-negative bacterial infections 失效
    疫苗对革兰氏阴性细菌感染

    公开(公告)号：US07235644B2

    公开(公告)日：2007-06-26

    申请号：US11375215

    申请日：2006-03-15

    申请人： Apurba Bhattacharjee ,  Alan Cross ,  Jerald Sadoff ,  Wendell Zollinger

    发明人： Apurba Bhattacharjee ,  Alan Cross ,  Jerald Sadoff ,  Wendell Zollinger

    IPC分类号： C07K16/00 ,  A61K39/40 ,  A61K39/395 ,  A61K38/16

    CPC分类号： A61K39/095 ,  A61K39/0258 ,  A61K2039/522 ,  Y02A50/474 ,  Y10S424/803 ,  Y10S530/806 ,  Y10S530/825

    摘要： A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.

    摘要翻译： 有效诱导产生免疫第二受试者的抗体的抗体被动物抗革兰氏阴性细菌感染和LPS介导的病理学的疫苗包含在源自大肠杆菌的纯化的，解毒的LPS之间形成的非共价多价复合物，以及 来源于脑膜炎奈瑟氏球菌的纯化外膜蛋白。 相同的疫苗也将主动免疫宿主受试者免受革兰氏阴性细菌感染和LPS介导的病理学。 脑膜炎球菌感染被包括在受疫苗保护的革兰氏阴性细菌感染中。

    Anti-cholesterolemic egg, vaccine and method for production, and use
    10.
    发明授权
    Anti-cholesterolemic egg, vaccine and method for production, and use 失效
    抗胆固醇血蛋，疫苗及生产方法及用途

    公开(公告)号：US5215746A

    公开(公告)日：1993-06-01

    申请号：US655815

    申请日：1991-02-15

    申请人： Ralph J. Stolle ,  Lee R. Beck

    发明人： Ralph J. Stolle ,  Lee R. Beck

    IPC分类号： A23C9/20 ,  A24B15/30 ,  A61K35/20 ,  A61K35/54 ,  A61K35/57 ,  A61K38/00 ,  C07K16/02 ,  C07K16/04

    CPC分类号： C07K16/02 ,  A23C9/20 ,  A24B15/30 ,  A61K35/57 ,  C07K16/04 ,  C07K2317/11 ,  Y10S424/803

    摘要： Anti-cholesterolemic eggs are disclosed, said eggs being obtained from animals hyperimmunized against at least one anti-cholesterolemic antigen. A vaccine producing said anti-cholesterolemic egg is disclosed, said vaccine comprising at least one anti-cholesterolemic antigen. Further, a dietary supplement for humans and other animals which does not elevate serum lipid concentrations is disclosed, said supplement comprising the anti-cholesterolemic eggs or fractions thereof. A method for treating vascular disorders in humans and other animals is also disclosed which comprises administering to said subjects said anti-cholesterolemic eggs for a time and in amounts sufficient to produce anti-arteriosclerotic effects, anti-aging vascular effects, and/or serum lipid-lowering effects.

    摘要翻译： 公开了抗胆固醇血症卵，所述卵从针对至少一种抗胆固醇血症抗原超免疫的动物获得。 公开了产生所述抗胆固醇血清蛋的疫苗，所述疫苗包含至少一种抗胆固醇血症抗原。 此外，公开了一种不提高血清脂质浓度的人类和其他动物的膳食补充剂，所述补充剂包含抗胆固醇血蛋白或其级分。 还公开了一种治疗人类和其它动物血管疾病的方法，其包括向所述受试者施用足以产生抗动脉硬化作用，抗老化血管作用和/或血清脂质的时间和量 - 下降的效果。