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公开(公告)号：US11740237B2
公开(公告)日：2023-08-29
申请号：US17052731
申请日：2019-05-03
申请人： Roger Karlsson , Edward R B Moore
发明人： Roger Karlsson , Edward R B Moore
IPC分类号： G01N33/569 , C07K14/21 , C07K14/245 , C07K14/285 , C07K14/315 , G01N33/68
CPC分类号： G01N33/56944 , C07K14/212 , C07K14/245 , C07K14/285 , C07K14/3156 , G01N33/6848 , G01N2469/10
摘要： The present invention provides specific peptide biomarkers and sets of peptide biomarkers for use in methods of detecting or identifying bacterial biomarkers in a sample, wherein said bacterial biomarkers can be used to detect Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, Escherichia coli, and/or Moraxella catarrhalis in a sample. Kits and diagnostic methods are also provided.
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2.发明申请公开(公告)号：US20180256700A1
公开(公告)日：2018-09-13
申请号：US15878491
申请日：2018-01-24
申请人： VAXDYN S.L , FUNDACIÓN PÚBLICA ANDALUZA PARA LA GESTIÓN DE LA INVESTIGACIÓN EN SALUD DE SEVILLA , SERVICIO ANDALUZ DE SALUD
发明人： Michael James McConnell , Meritxell García Quintanilla , Marina Pulido Toledano , María Pilar Pérez Romero , Jerónimo Pachón Díaz , Juan José Infante Viñolo
CPC分类号： A61K39/104 , A61K35/74 , A61K2039/505 , A61K2039/521 , A61K2039/575 , C07K14/212 , C07K16/1203 , C07K2319/00 , C12N9/1025 , C12N9/1048 , C12N9/78
摘要： The invention refers to a composition comprising inactivated cells deficient in LPS from the genus Acinetobacter and/or outer membrane vesicles form the same and their use for the manufacture of a medicament, preferably a vaccine, for the prevention of diseases produced by organisms of the genus Acinetobacter.
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公开(公告)号：US20170304425A1
公开(公告)日：2017-10-26
申请号：US15427976
申请日：2017-02-08
发明人： Simon Urwyler , Markus Haake , Michael Rudolf
IPC分类号： A61K39/104 , C07K14/21 , C07K16/12 , C07K14/22 , A61K39/00
CPC分类号： A61K39/1045 , A61K39/104 , A61K2039/55555 , C07K14/212 , C07K14/22 , C07K16/1217
摘要： The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
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公开(公告)号：US08722050B2
公开(公告)日：2014-05-13
申请号：US13708767
申请日：2012-12-07
发明人： Xiao-Qing Qiu
IPC分类号： A61K39/395
CPC分类号： C07K16/085 , A61K38/00 , A61K38/164 , A61K47/64 , C07K14/212 , C07K14/24 , C07K14/245 , C07K14/32 , C07K14/34 , C07K14/705 , C07K2317/56 , C07K2317/565 , C07K2318/10 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C12N15/62
摘要： The present invention relates to methods of treating virus-induced cancer with the polypeptides that are capable of killing cells. The polypeptide comprises a targeting agent covalently attached to a channel-forming moiety. In a preferred embodiment, the channel-forming moiety comprises a colicin and the targeting agent is a reconstructed antibody mimetic derived from monoclonal antibody variants against Epstein-Barr virus gp350/220.
摘要翻译： 本发明涉及用能够杀死细胞的多肽来治疗病毒诱导的癌症的方法。 多肽包含共价连接到通道形成部分的靶向剂。 在优选的实施方案中，通道形成部分包含大肠杆菌素，并且靶向剂是衍生自针对爱泼斯坦 - 巴尔病毒gp350 / 220的单克隆抗体变体的重建抗体模拟物。
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5.发明申请公开(公告)号：US20130143268A1
公开(公告)日：2013-06-06
申请号：US13708760
申请日：2012-12-07
发明人： Xiao-Qing QIU
IPC分类号： C07K14/245
CPC分类号： C07K16/085 , A61K38/00 , A61K38/164 , A61K47/64 , C07K14/212 , C07K14/24 , C07K14/245 , C07K14/32 , C07K14/34 , C07K14/705 , C07K2317/56 , C07K2317/565 , C07K2318/10 , C07K2318/20 , C07K2319/00 , C07K2319/01 , C12N15/62
摘要： The present invention relates to methods of producing the polypeptides that are capable of killing cells. The polypeptides comprise a targeting agent covalently attached to a channel-forming moiety. In a preferred embodiment, the channel-forming moiety comprises a colicin and the targeting agent is a reconstructed antibody mimetic derived from monoclonal antibody variants against Epstein-Barr virus gp350/220.
摘要翻译： 本发明涉及产生能够杀死细胞的多肽的方法。 多肽包含共价连接到通道形成部分的靶向剂。 在优选的实施方案中，通道形成部分包含大肠杆菌素，并且靶向剂是衍生自针对爱泼斯坦 - 巴尔病毒gp350 / 220的单克隆抗体变体的重建抗体模拟物。
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6.发明授权Interaction of Moraxella catarrhalis with epithelial cells, extracellular matrix proteins and the complement system 有权卡他莫拉菌与上皮细胞，细胞外基质蛋白和补体系的相互作用公开(公告)号：US08323667B2
公开(公告)日：2012-12-04
申请号：US13314727
申请日：2011-12-08
申请人： Arne Forsgren , Kristian Riesbeck
发明人： Arne Forsgren , Kristian Riesbeck
IPC分类号： A61K39/02 , C07K14/195
CPC分类号： A61K39/1045 , A61K39/02 , A61K39/104 , C07K14/195 , C07K14/212 , C07K14/78 , C07K19/00 , C12N15/09 , C12N15/101 , G01N30/02
摘要： The present disclosure relates to surface proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin and laminin, and also to their ability to inhibit the complement system. These surface proteins are useful in the preparation of vaccines. The present disclosure also provides peptides interacting with fibronectin, laminin and the complement system.
摘要翻译： 本公开内容涉及卡他莫拉菌的表面蛋白及其通过细胞相关纤连蛋白和层粘连蛋白与上皮细胞相互作用的能力，以及其抑制补体系统的能力。 这些表面蛋白质可用于制备疫苗。 本公开还提供了与纤连蛋白，层粘连蛋白和补体系相互作用的肽。
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7.发明授权Interaction of Moraxella catarrhalis with epithelial cells, extracellular matrix proteins and the complement system 有权卡他莫拉菌与上皮细胞，细胞外基质蛋白和补体系的相互作用公开(公告)号：US08092811B2
公开(公告)日：2012-01-10
申请号：US12063408
申请日：2006-08-08
申请人： Arne Forsgren , Kristian Riesbeck
发明人： Arne Forsgren , Kristian Riesbeck
IPC分类号： A61K39/02 , C07K14/195
CPC分类号： A61K39/1045 , A61K39/02 , A61K39/104 , C07K14/195 , C07K14/212 , C07K14/78 , C07K19/00 , C12N15/09 , C12N15/101 , G01N30/02
摘要： The present invention relates to surface proteins of Moraxella catarrhalis and their ability to interact with epithelial cells via cell-associated fibronectin and laminin, and also to their ability to inhibit the complement system. These surface proteins are useful in the preparation of vaccines. The present invention also provides peptides interacting with fibronectin, laminin and the complement system.
摘要翻译： 本发明涉及卡他莫拉菌的表面蛋白及其通过细胞相关纤连蛋白和层粘连蛋白与上皮细胞相互作用的能力，以及其抑制补体系统的能力。 这些表面蛋白质可用于制备疫苗。 本发明还提供了与纤连蛋白，层粘连蛋白和补体系相互作用的肽。
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公开(公告)号：US07846451B2
公开(公告)日：2010-12-07
申请号：US12004502
申请日：2007-12-21
申请人： Kenneth Tucker , Ulrich F. Tillman
发明人： Kenneth Tucker , Ulrich F. Tillman
CPC分类号： C07K14/212 , A61K38/00 , A61K39/00 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/53 , C07K16/1214 , C07K2317/734
摘要： The invention discloses the Moraxella catarrhalis outer membrane protein polypeptide and polypeptides derived therefrom (collectively “OMP21”), nucleotide sequences encoding said OMP21, and antibodies that specifically bind OMP21. Also disclosed are pharmaceutical compositions including prophylactic or therapeutic compositions, which may be immunogenic compositions including vaccines, comprising OMP21, antibodies thereto or nucleotides encoding same. The invention additionally discloses methods of inducing an immune response to M. catarrhalis and OMP21 in an animal, preferably a human, methods of treating and methods of diagnosing Moraxella infections in an animal, preferably a human, and kits therefor.
摘要翻译： 本发明公开了卡他莫拉菌外膜蛋白多肽及其衍生的多肽（统称为“OMP21”），编码所述OMP21的核苷酸序列，以及特异性结合OMP21的抗体。 还公开了包含预防或治疗组合物的药物组合物，其可以是包含OMP21，其抗体或其编码核苷酸的疫苗的免疫原性组合物。 本发明另外公开了在动物，优选人类的治疗方法和动物，优选人类中诊断莫拉菌感染的方法及其试剂盒中诱导对卡他莫拉菌和OMP21的免疫应答的方法。
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9.发明授权BASB027 proteins and genes from Moraxella catarrhalis, antigens, antibodies, and uses 失效BASB027蛋白质和卡他莫拉菌的基因，抗原，抗体和用途公开(公告)号：US07641910B2
公开(公告)日：2010-01-05
申请号：US10896725
申请日：2004-07-22
CPC分类号： C07K14/212 , A61K39/00 , C07K2319/00
摘要： The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
摘要翻译： 本发明提供BASB027多肽和编码BASB027多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供诊断，预防和治疗用途。
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公开(公告)号：US07632516B1
公开(公告)日：2009-12-15
申请号：US10048574
申请日：2000-07-27
申请人： Joelle Thonnard
发明人： Joelle Thonnard
CPC分类号： C07K14/212 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K2319/00
摘要： The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
摘要翻译： 本发明提供了BASB115多肽和编码BASB115多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供诊断，预防和治疗用途。
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