公开(公告)号：US06803043B1

公开(公告)日：2004-10-12

申请号：US09701711

申请日：2001-07-27

Applicant: Carlota Vinals y de Bassols

Inventor： Carlota Vinals y de Bassols

IPC: A61K3902

CPC classification number: C07K14/212 ,  A61K39/00 ,  C07K2319/00

Abstract: The invention provides BASB027 polypeptides and polynucleotides encoding BASB027 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

Abstract translation: 本发明提供BASB027多肽和编码BASB027多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供诊断，预防和治疗用途。

公开(公告)号：US06761891B1

公开(公告)日：2004-07-13

申请号：US09508096

申请日：2000-07-06

Applicant: Markus M. Simon ,  Weimin Zhong ,  Reinhard Wallich ,  Michael D. Kramer

Inventor： Markus M. Simon ,  Weimin Zhong ,  Reinhard Wallich ,  Michael D. Kramer

IPC: A61K3902

CPC classification number: C07K14/20 ,  A61K38/00 ,  A61K39/00 ,  C07K16/1207 ,  C07K2319/00 ,  Y02A50/401

Abstract: A pharmaceutical composition for treating Lyme disease contains an antibody as an active agent which is specific for the 24 kDa antigen (OspC) of B. burgdorferi, preferably an antibody which is specific for the 24 kDa antigen (OspC) of B. burgdorferi having the sequence shown in SEQ ID NO.2.

Abstract translation: 用于治疗莱姆病的药物组合物含有作为活性剂的抗体，其对布氏疏螺旋体的24kDa抗原（OspC）是特异性的，优选地是对具有Burgdorferi的24kDa抗原（OspC）特异性的抗体 序列如SEQ ID NO.2所示。

公开(公告)号：US06699482B2

公开(公告)日：2004-03-02

申请号：US09992807

申请日：2001-11-13

Applicant: David A. Haake ,  Ellen S. Shang

Inventor： David A. Haake ,  Ellen S. Shang

IPC: A61K3902

CPC classification number: C07K14/20 ,  A61K39/00 ,  C07K2319/00 ,  Y02A50/48

Abstract: The present invention presents novel leptospiral membrane lipoproteins, LipL1 and LipL2, associated with pathogenic strains of Leptospira. LipL1 is of about 35 kDa, and LipL2 is of about 41 kDa. Also disclosed are the method for purifying these proteins from Leptospira, their nucleotide and amino acid sequences, the cloning of the genes encoding the proteins and their recombinant proteins, methods for producing antibodies to these proteins, the resulting antibodies. These proteins, their immunogenic fragments, and antibodies against them, are useful for inducing an immune response to pathogenic Leptospira as well as providing a diagnostic target for leptospirosis.

Abstract translation: 本发明提出了与钩端螺旋体致病菌株相关的新型钩端螺旋体脂蛋白LipL1和LipL2。 LipL1为约35kDa，LipL2为约41kDa。 还公开了从钩端螺旋体纯化这些蛋白质的方法，其核苷酸和氨基酸序列，编码蛋白质及其重组蛋白质的基因的克隆，产生抗体的方法。 这些蛋白质，其免疫原性片段和针对它们的抗体可用于诱导针对病原性钩端螺旋体的免疫应答，以及为钩端螺旋体病提供诊断目标。

公开(公告)号：US06669940B2

公开(公告)日：2003-12-30

申请号：US09841786

申请日：2001-04-24

Applicant: Tiruvoor G. Nagaraja ,  George C. Stewart ,  Sanjeev K. Narayanan ,  Muckatira M. Chengappa

Inventor： Tiruvoor G. Nagaraja ,  George C. Stewart ,  Sanjeev K. Narayanan ,  Muckatira M. Chengappa

IPC: A61K3902

CPC classification number: C07K14/195 ,  A61K39/00

Abstract: The F. necrophorum gene expressing leukotoxin was sequenced and cloned. The leukotoxin open reading frame (lktA) is part of a multi-gene operon containing 9,726 bp, and encoding a protein containing 3,241 amino acids with an overall molecular weight of 335,956 daltons. The protein encoded by the gene was truncated into five polypeptides having overlapping regions by truncating the full length gene into five different sections and amplifying, expressing, and recovering the protein encoded by each of these sections. Additionally, a region upstream of the gene was sequenced and the polypeptide encoded by that nucleotide sequence was purified and isolated. These polypeptides along with the full length protein are then tested to determine their immunogenicity and protective immunity in comparison to the efficacy of immunization conferred by inactivated native leukotoxin in F. necrophorum culture supernatant.

公开(公告)号：US06667038B1

公开(公告)日：2003-12-23

申请号：US09553863

申请日：2000-04-20

Applicant: Sam T. Donta ,  Mark J. Cartwright

Inventor： Sam T. Donta ,  Mark J. Cartwright

IPC: A61K3902

CPC classification number: C07K14/20 ,  A61K39/00 ,  C07K2319/00 ,  Y02A50/401 ,  Y02A50/472

Abstract: The present invention provides compositions and methods related to Borrelia burgdorferi toxin and antitoxin preparations. In particular, the present invention provides methods and compositions for the diagnosis of Lyme disease, as well as for use in treating subjects infected with B. burgdorferi through passive immunization, and vaccine development.

Abstract translation: 本发明提供了与布氏疏螺旋体毒素和抗毒素制剂有关的组合物和方法。 特别地，本发明提供了用于诊断莱姆病的方法和组合物，以及用于通过被动免疫来治疗感染B型胆固醇的受试者和疫苗开发。

公开(公告)号：US06660274B2

公开(公告)日：2003-12-09

申请号：US09445803

申请日：1999-12-13

Applicant: Mario T. Philipp

Inventor： Mario T. Philipp

IPC: A61K3902

CPC classification number: C07K14/20 ,  A61K38/00 ,  A61K39/00 ,  Y02A50/401

Abstract: A novel isolated Borrielia burgdorferi sensu lato surface antigen is characterized by a relative molecular mass of 39.5 kDa. This antigen is expressed in vitro by spirochetes of a B. burgdorferi sensu lato strain. This antigen induces antibodies which kill spirochetes of a B. burgdorferi sensu lato strain by ADCK in vitro. Novel Borrelia cassette string protein or fragments thereof are also useful, as is the P39.5 protein in diagnosing Lyme disease and in compositions for treatment or prophylaxis thereof.

Abstract translation: 一种新型分离的Borrielia burgdorferi感觉表面抗原的特征在于相对分子质量为39.5kDa。 该抗原在体外通过布氏疏螺旋体菌株的螺旋体表达。 该抗原通过体外诱导通过ADCK杀死布氏疏螺旋体感染菌株的螺旋体的抗体。 新颖的Borrelia盒式串联蛋白或其片段也是有用的，P39.5蛋白质在诊断莱姆病和用于治疗或预防它们的组合物中也是有用的。

公开(公告)号：US06649171B1

公开(公告)日：2003-11-18

申请号：US09719190

申请日：2000-12-08

Applicant: Joelle Thonnard

Inventor： Joelle Thonnard

IPC: A61K3902

CPC classification number: C07K14/212 ,  A61K39/00

Abstract: The invention provides BASB021 polypeptides and polynucleotides encoding BASB021 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.

Abstract translation: 本发明提供了BASB021多肽和编码BASB021多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供诊断，预防和治疗用途。

公开(公告)号：US06613335B1

公开(公告)日：2003-09-02

申请号：US09673899

申请日：2000-12-19

Applicant: Jean-Louis Ruelle

Inventor： Jean-Louis Ruelle

IPC: A61K3902

CPC classification number: C07K14/22 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51

Abstract: Provided are BASB011 polypeptides and polynucleotides encoding BASB011 polypeptide from Moraxella catarrhalis. Also provided are immunogenic uses.

Abstract translation: 提供BASB011多肽和编码来自卡他莫拉菌的BASB011多肽的多核苷酸。 还提供免疫原性用途。

公开(公告)号：US06610301B1

公开(公告)日：2003-08-26

申请号：US09242299

申请日：1999-02-12

Applicant: Manfred Motz ,  Erwin Soutschek

Inventor： Manfred Motz ,  Erwin Soutschek

IPC: A61K3902

CPC classification number: C07K14/20 ,  A61K39/00 ,  A61K2039/51 ,  Y02A50/401

Abstract: The present invention relates to immunologically active proteins from Borrelia burgdorferi which are present in a form which is free of other proteins derived from Borrelia burgdorferi and which exhibit the sequence of the protein 1829-22A, which has the amino acid sequence MKKFNLIIEALFAILLTACNFGLMEETKIALESSSKDVKNKILQIKKDAEDKGVNFAAFTSSETG SKVTNGGLALREAKIQAINEVEKFLKRIEEEALKLKEHGNSGQFLELFDLLLEVLESLEPIGIKG LKDFISEEAKCNPISTSERLIEVKVQIENKMEEVKRKQNLNKERKSNKGKKKK SEQ. ID NO.: 1 or a part sequence thereof having at least 10 consecutive amino acids, or exhibit the sequence of the protein 1829-22B, which has the amino acid sequence MIKYNKIILTLTLLASLLAACSLTGKARLESSVKDITNEIEKAIKEAEDAGVKTDAFTETQTGGK VAGPKIRAAKIRVADLTIKFLEATEEETITFKENGAGEDEFSGIYDLILNAAKAVEKIGMKDMTK TVEEAAKENPKTTANGIIEIVKVMKAKVENIKEKQTKNQK SEQ. ID NO.: 2 or a part sequence thereof having at least 10 consecutive amino acids.

Abstract translation: 本发明涉及由莱姆病螺旋体免疫活性的蛋白质，其存在于一种形式，其不含来自伯氏疏螺旋和其表现出的蛋白1829-22A，其具有氨基酸sequenceMKKFNLIIEALFAILLTACNFGLMEETKIALESSSKDVKNKILQIKKDAEDKGVNFAAFTSSETG SKVTNGGLALREAKIQAINEVEKFLKRIEEEALKLKEHGNSGQFLELFDLLLEVLESLEPIGIKG LKDFISEEAKCNPISTSERLIEVKVQIENKMEEVKRKQNLNKERKSNKGKKKK SEQ的序列衍生其它蛋白质。 或具有至少10个连续氨基酸的部分序列，或表现出具有氨基酸序列的蛋白质1829-22B的序列，其具有以下氨基酸序列：MIKYNKIILTLTLLASLLAACSLTGKARLESSVKDITNEIEKAIKEAEDAGVKTDAFTETQTGGK VAGPKIRAAKIRVADLTIKFLEATEEETITFKENGAGEDEFSGIYDLILNAAKAVEKIGMKDMTK TVEEAAKENPKTTANGIIEIVKVMKAKVENIKEKQTKNQK SEQ ID NO： ID号：2或其具有至少10个连续氨基酸的部分序列。

公开(公告)号：US06602506B1

公开(公告)日：2003-08-05

申请号：US09318141

申请日：1999-05-25

Applicant: Pierre B. van der Bruggen ,  Guy R. Cornelis ,  Anne M. Boland ,  Thierry R. Boon-Falleur

Inventor： Pierre B. van der Bruggen ,  Guy R. Cornelis ,  Anne M. Boland ,  Thierry R. Boon-Falleur

IPC: A61K3902

CPC classification number: C12R1/01 ,  A61K38/00 ,  A61K48/00 ,  C07K14/24 ,  C07K14/4748 ,  C12N15/74 ,  C12N15/87

Abstract: The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.

Abstract translation: 本发明涉及重组耶尔霉素及其用于将蛋白递送到真核细胞中的用途，包括相关组合物和治疗方法以及相关测定。